Recent Submissions

  • Synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-Halo-3-phenylcoumarins 

    Quezada González, Elías Neftalí; Delogu, Giovanna; Picciau, Carmen; Santana Penín, María Lourdes; Podda, Gianni; Borges, Fernanda; García Morales, Verónica; Viña Castelao, María Dolores; Orallo Cambeiro, Francisco (MDPI, 2010)
    A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant ...
  • Co-delivery of RNAi and Chemokine by Polyarginine Nanocapsules Enables the Modulation of Myeloid-Derived Suppressor Cells 

    Martínez Ledo, Adriana; Sasso, Maria A.; Bronte, Vincenzo; Marigo, Ilaria; Boyd, Ben J.; García Fuentes, Marcos; Alonso Fernández, María José (Elsevier, 2019)
    Myeloid-Derived Suppressor Cells (MDSCs), immunosuppressive cells that promote tumor growth, represent an attractive target in cancer immunotherapy. However, the clinical success of this strategy is limited by the lack of ...
  • Extracellular matrix mechanics regulate transfection and SOX9-directed differentiation of mesenchymal stem cells 

    Martínez Ledo, Adriana; Vining, Kyle H.; Alonso Fernández, María José; García Fuentes, Marcos; Mooney, David J. (Elsevier, 2020)
    Gene delivery within hydrogel matrices can potentially direct mesenchymal stem cells (MSCs) towards a chondrogenic fate to promote regeneration of cartilage. Here, we investigated whether the mechanical properties of the ...
  • mRNA-activated matrices encoding transcription factors as primers of cell differentiation in tissue engineering 

    Martínez Ledo, Adriana; Senra, Ana; Rilo Álvarez, Héctor; Borrajo Alonso, Erea; Vidal Figueroa, Anxo; Alonso Fernández, María José; García Fuentes, Marcos (Elsevier, 2020)
    Gene-activated matrices (GAMs) encoding pivotal transcription factors (TFs) represent a powerful tool to direct stem cell specification for tissue engineering applications. However, current TF-based GAMs activated with ...
  • Artificial intelligence applied to flavonoid data in food matrices 

    Guardado Yordi, Estela; Koelig, Raúl; Matos, Maria João Correia Pinto Carvalho de; Pérez Martínez, Amaury; Caballero, Yailé; Santana Penín, María Lourdes; Pérez Quintana, Manuel; Molina, Enrique; Uriarte Villares, Eugenio (MDPI, 2019)
    Increasing interest in constituents and dietary supplements has created the need for more efficient use of this information in nutrition-related fields. The present work aims to obtain optimal models to predict the total ...

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