• Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool 

  Cabezas Sáinz, Pablo; Guerra Varela, Jorge; Carreira, María J.; Mariscal, Javier; Roel, María; Rubiolo Gaytán, Juan Andrés; Sciara, Andrés; Abal Posada, Miguel; Botana, Luis M; López, Rafael; Sánchez Piñón, Laura (Springer Nature, 2017)

  Background Zebrafish (Danio rerio) is a model organism that has emerged as a tool for cancer research, cancer being the second most common cause of death after cardiovascular disease for humans in the developed world. ...

• A new potential nano-oncological therapy based on polyamino acid nanocapsules 

  Gonzalo, Teresa; Lollo, Giovanna; García-Fuentes, Marcos; Torres, Dolores; Correa, Juan; Riguera, Ricardo; Fernandez-Megia, Eduardo; Calvo, Pilar; Avilés, Pablo; Guillén, Maria José; Alonso, María José (Elsevier, 2013-07)

  A critical objective in cancer therapy is to reduce the systemic toxicity through the modification of the biodistribution of anticancer drugs. Herein, we disclose a new biodegradable nanocarrier, polyglutamic acid (PGA) ...

• Exploring the efficiency of gallic acid-based dendrimers and their block copolymers with PEG as gene carriers 

  Fuente, María de la; Raviña, Manuela; Sousa-Herves, Ana; Correa, Juan; Riguera, Ricardo; Fernandez-Megia, Eduardo; Sánchez, Alejandro; Alonso, María José (Future Science, 2012-07-20)

  The synthesis of a new family of amino-functionalized gallic acid-triethylene glycol (GATG) dendrimers and their block copolymers with polyethylene glycol (PEG) has recently being disclosed. In addition, these dendrimers ...

• Heart Alterations after Domoic Acid Administration in Rats 

  Crespo Vieira, Andrés; Cifuentes, José Manuel; Bermúdez, Roberto; Fernández Ferreiro, Sara; Román Castro, Albina; Botana, Luis M (MDPI AG, 2016-03-10)

  Domoic acid (DA) is one of the best known marine toxins, causative of important neurotoxic alterations. DA effects are documented both in wildlife and experimental assays, showing that this toxin causes severe injuries ...

• How Safe Is Safe for Marine Toxins Monitoring? 

  Botana, Luis M; Alfonso, Amparo; Rodríguez, Inés; Botana, Ana M; Louzao, M. Carmen; Rodríguez Vieytes, María Mercedes (MDPI AG, 2016-07-06)

  Current regulation for marine toxins requires a monitoring method based on mass spectrometric analysis. This method is pre-targeted, hence after searching for pre-assigned masses, it identifies those compounds that were ...

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