Now showing items 1-5 of 5

    • Biopharmaceutical Assessment of Dexamethasone Acetate-Based Hydrogels Combining Hydroxypropyl Cyclodextrins and Polysaccharides for Ocular Delivery 

      Mazet, Roseline; García Otero, Xurxo; Choisnard, Luc; Wouessidjewe, Denis; Verdoot, Vincent; Bossard, Frédéric; Díaz Tomé, Victoria; Blanc Marquis, Véronique; Otero Espinar, Francisco Javier; Fernández Ferreiro, Anxo; Gèze, Annabelle (MDPI, 2020)
      We previously developed two optimized formulations of dexamethasone acetate (DXMa) hydrogels by means of special cubic mixture designs for topical ocular administration. These gels were elaborated with hydroxypropyl-β-CD ...
    • Development and Characterization of a Tacrolimus/Hydroxypropyl-β-Cyclodextrin Eye Drop 

      García Otero, Xurxo; Díaz Tomé, Victoria; Varela Fernández, Rubén; Martín Pastor, Manuel; González Barcia, Luis Miguel; Blanco Méndez, José; Mondelo García, Cristina; Álvarez Bermúdez, María José; González García, Francisco; Aguiar Fernández, Pablo; Fernández Ferreiro, Anxo; Otero Espinar, Francisco Javier (MDPI, 2021)
      Uveitis is a vision inflammatory disorder with a high prevalence in developing countries. Currently, marketed treatments remain limited and reformulation is usually performed to obtain a tacrolimus eye drop as a therapeutic ...
    • Enhancement in corneal permeability of riboflavin using cyclodextrin derivates complexes as a previous step to transepithelial cross-linking 

      Conde Penedo, Andrea; Díaz Tomé, Victoria; Fernández Ferreiro, Anxo; González Barcia, Miguel; Otero Espinar, Francisco Javier (Elsevier, 2021)
      Corneal cross-linking has been described as an effective treatment to slow the progression of keratoconus. The standard protocol entails corneal epithelial removal to allow the diffusion of riboflavin into the stroma. ...
    • Lactoferrin-loaded nanostructured lipid carriers (NLCs) as a new formulation for optimized ocular drug delivery 

      Varela Fernández, Rubén; García Otero, Xurxo; Díaz Tomé, Victoria; Regueiro Lorenzo, Uxía; López López, María Teresa; González Barcia, Miguel; Lema Gesto, María Isabel; Otero Espinar, Francisco Javier (Elsevier, 2022)
      Nanostructured lipid carriers (NLC) are novel lipidic nanosystems that provide significant improvements in terms of high drug loading capacity and controlled drug release. The purpose of the present work was based on the ...
    • Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy 

      Moles Aranda, Cristina; Calpena Campmany, Ana Cristina; Halbaut Bellowa, Lyda; Díaz Tomé, Victoria; Otero Espinar, Francisco Javier; Morales Molina, José A.; Clares Naveros, Beatriz (MDPI, 2020)
      Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are two techniques used in the resection of gastrointestinal mucosal polyps. The aim of this work is the development and evaluation of an ...





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