Now showing items 1-4 of 4

    • Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation Using CT imaging 

      Gómez Lado, Noemí; Seoane Viaño, Iria; Matiz, Silvia; Madla, Christine M.; Yadav, Vipul; Aguiar Fernández, Pablo; Basit, Abdul W.; Goyanes Goyanes, Álvaro (MDPI, 2020)
      Following oral administration, gastric emptying is often a rate-limiting step in the absorption of drugs and is dependent on both physiological and pharmaceutical factors. To guide translation into humans, small animal ...
    • Ocular biodistribution studies using molecular imaging 

      Castro Balado, Ana; Mondelo García, Cristina; González Barcia, Miguel; Zarra Ferro, Irene; Otero Espinar, Francisco Javier; Ruibal Morell, Álvaro; Aguiar Fernández, Pablo; Fernández Ferreiro, Anxo (MDPI, 2019)
      Classical methodologies used in ocular pharmacokinetics studies have difficulties to obtain information about topical and intraocular distribution and clearance of drugs and formulations. This is associated with multiple ...
    • Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration 

      García Quintanilla, Laura; Luaces Rodríguez, Andrea; Gil Martínez, María; Mondelo García, Cristina; Maroñas Amigo, Olalla; Mangas Sanjuán, Víctor; González Barcia, Miguel; Zarra Ferro, Irene; Aguiar Fernández, Pablo; Otero Espinar, Francisco Javier; Fernández Ferreiro, Anxo (MDPI, 2019)
      Intravitreal administration of anti-vascular endothelial growth factor (VEGF) antibodies has become the standard treatment for Age-Related Macular Degeneration; however, the knowledge of their pharmacokinetics is limited. ...
    • Preclinical PET Study of Intravitreal Injections 

      Fernández Ferreiro, Anxo; Luaces Rodríguez, Andrea; Aguiar Fernández, Pablo; Pardo Montero, Juan; González Barcia, Miguel; García Varela, Lara; Herranz, Michel; Silva Rodríguez, Jesús; Gil Martínez, María; Bermúdez Vázquez, María Elvira; Vieites Prado, Alba; Blanco Méndez, José; Lamas Díaz, María Jesús; Gómez-Ulla de Irazazábal, Francisco Javier; Ruibal Morell, Álvaro; Otero Espinar, Francisco Javier; González García, Francisco (The Association for Research in Vision and Ophthalmology, 2017)
      PURPOSE. This work aimed at describing the time course of vitreous clearance through the use of positron emission tomography (PET) as a noninvasive tool for pharmacokinetic studies of intravitreal injection. METHODS. ...

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