Now showing items 1-4 of 4

    • 3D Printed Tacrolimus Rectal Formulations Ameliorate Colitis in an Experimental Animal Model of Inflammatory Bowel Disease 

      Seoane Viaño, Iria; Gómez Lado, Noemí; Lázare Iglesias, Héctor; García Otero, Xurxo; Antúnez López, José Ramón; Ruibal Morell, Álvaro; Varela Correa, Juan Jesús; Aguiar Fernández, Pablo; Basit, Abdul W.; Otero Espinar, Francisco Javier; González Barcia, Miguel; Goyanes Goyanes, Álvaro; Luzardo Álvarez, Asteria María; Fernández Ferreiro, Anxo (MDPI, 2020)
      The aim of this study was to fabricate novel self-supporting tacrolimus suppositories using semisolid extrusion 3-dimensional printing (3DP) and to investigate their efficacy in an experimental model of inflammatory bowel ...
    • Biopharmaceutical Assessment of Dexamethasone Acetate-Based Hydrogels Combining Hydroxypropyl Cyclodextrins and Polysaccharides for Ocular Delivery 

      Mazet, Roseline; García Otero, Xurxo; Choisnard, Luc; Wouessidjewe, Denis; Verdoot, Vincent; Bossard, Frédéric; Díaz Tomé, Victoria; Blanc Marquis, Véronique; Otero Espinar, Francisco Javier; Fernández Ferreiro, Anxo; Gèze, Annabelle (MDPI, 2020)
      We previously developed two optimized formulations of dexamethasone acetate (DXMa) hydrogels by means of special cubic mixture designs for topical ocular administration. These gels were elaborated with hydroxypropyl-β-CD ...
    • Development and Characterization of a Tacrolimus/Hydroxypropyl-β-Cyclodextrin Eye Drop 

      García Otero, Xurxo; Díaz Tomé, Victoria; Varela Fernández, Rubén; Martín Pastor, Manuel; González Barcia, Luis Miguel; Blanco Méndez, José; Mondelo García, Cristina; Álvarez Bermúdez, María José; González García, Francisco; Aguiar Fernández, Pablo; Fernández Ferreiro, Anxo; Otero Espinar, Francisco Javier (MDPI, 2021)
      Uveitis is a vision inflammatory disorder with a high prevalence in developing countries. Currently, marketed treatments remain limited and reformulation is usually performed to obtain a tacrolimus eye drop as a therapeutic ...
    • Lactoferrin-loaded nanostructured lipid carriers (NLCs) as a new formulation for optimized ocular drug delivery 

      Varela Fernández, Rubén; García Otero, Xurxo; Díaz Tomé, Victoria; Regueiro Lorenzo, Uxía; López López, María Teresa; González Barcia, Miguel; Lema Gesto, María Isabel; Otero Espinar, Francisco Javier (Elsevier, 2022)
      Nanostructured lipid carriers (NLC) are novel lipidic nanosystems that provide significant improvements in terms of high drug loading capacity and controlled drug release. The purpose of the present work was based on the ...





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