Now showing items 1-19 of 19

    • Advances on the formulation of proteins using nanotechnologies 

      Santalices Ramos, Irene; Gonella, Andrea; Torres López, María Dolores Ramona; Alonso Fernández, María José (Elsevier, 2017-12)
      Therapeutic proteins and peptides are very attractive from the pharmaceutical point of view due to their high potency and selectivity. Nonetheless, their instability and low bioavailability make their adminis- tration ...
    • Chitosan-coated mesoporous MIL-100(Fe) nanoparticles as improved bio-compatible oral nanocarriers 

      Hidalgo, T.; Giménez Marqués, M.; Bellido, E.; Avila, J.; Asensio, M.C.; Salles, F.; Lozano, M.V.; Guillevic, M.; Simón Vázquez, Rosana; González Fernández, África; Serre, C.; Alonso Fernández, María José; Horcajada, P. (Springer Nature, 2017)
      Nanometric biocompatible Metal-Organic Frameworks (nanoMOFs) are promising candidates for drug delivery. Up to now, most studies have targeted the intravenous route, related to pain and severe complications; whereas nanoMOFs ...
    • Chitosan-Poly (I:C)-PADRE Based Nanoparticles as Delivery Vehicles for Synthetic Peptide Vaccines 

      Correia Pinto, Jorge F.; Csaba, Noemi Stefania; Schiller, John T.; Alonso Fernández, María José (MDPI, 2015)
      The safety and precision of peptide antigens has prompted the search for adjuvants capable of increasing the immune response against these intrinsically poorly immunogenic antigens. The integration of both immunostimulants ...
    • Co-delivery of RNAi and Chemokine by Polyarginine Nanocapsules Enables the Modulation of Myeloid-Derived Suppressor Cells 

      Martínez Ledo, Adriana; Sasso, Maria A.; Bronte, Vincenzo; Marigo, Ilaria; Boyd, Ben J.; García Fuentes, Marcos; Alonso Fernández, María José (Elsevier, 2019)
      Myeloid-Derived Suppressor Cells (MDSCs), immunosuppressive cells that promote tumor growth, represent an attractive target in cancer immunotherapy. However, the clinical success of this strategy is limited by the lack of ...
    • Engineering, on-demand manufacturing, and scaling-up ofpolymeric nanocapsules 

      Crecente Campo, José; Alonso Fernández, María José (Willey, 2019)
      Polymeric nanocapsules are versatile delivery systems with the capacity to load lipophilic drugs in their oily nucleus and hydrophilic drugs in their polymeric shell. The objective of this work was to expand the technological ...
    • Exploring the efficiency of gallic acid-based dendrimers and their block copolymers with PEG as gene carriers 

      Fuente Freire, María de la; Raviña Fernández, Manuela; Sousa Hervés, Ana; Correa, Juan; Riguera Vega, Ricardo; Fernández Megía, Eduardo; Sánchez Barreiro, Alejandro; Alonso Fernández, María José (Future Science, 2012-07-20)
      The synthesis of a new family of amino-functionalized gallic acid-triethylene glycol (GATG) dendrimers and their block copolymers with polyethylene glycol (PEG) has recently being disclosed. In addition, these dendrimers ...
    • Extracellular matrix mechanics regulate transfection and SOX9-directed differentiation of mesenchymal stem cells 

      Martínez Ledo, Adriana; Vining, Kyle H.; Alonso Fernández, María José; García Fuentes, Marcos; Mooney, David J. (Elsevier, 2020)
      Gene delivery within hydrogel matrices can potentially direct mesenchymal stem cells (MSCs) towards a chondrogenic fate to promote regeneration of cartilage. Here, we investigated whether the mechanical properties of the ...
    • mRNA-activated matrices encoding transcription factors as primers of cell differentiation in tissue engineering 

      Martínez Ledo, Adriana; Senra, Ana; Rilo Álvarez, Héctor; Borrajo Alonso, Erea; Vidal Figueroa, Anxo; Alonso Fernández, María José; García Fuentes, Marcos (Elsevier, 2020)
      Gene-activated matrices (GAMs) encoding pivotal transcription factors (TFs) represent a powerful tool to direct stem cell specification for tissue engineering applications. However, current TF-based GAMs activated with ...
    • Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques 

      Li, Hongzhao; Hai, Yan; Lim, So-Yon; Toledo, Nikki; Crecente Campo, José; Schalk, Dane; Li, Lin; Omange, Robert W.; Gómez Dacoba, Tamara; Liu, Lewis R.; Kashem, Mohammad Abul; Wan, Yanmin; Liang, Binhua; Li, Qingsheng; Rakasz, Eva; Schultz-Darken, Nancy; Alonso Fernández, María José; Plummer, Francis A.; Whitney, James B.; Luo, Ma (PLOS, 2018)
      HIV mutates rapidly and infects CD4+ T cells, especially when they are activated. A vaccine targeting conserved, essential viral elements while limiting CD4+ T cell activation could be effective. Learning from natural ...
    • Natural and cross-inducible anti-SIV antibodies in Mauritian cynomolgus macaques 

      Li, Hongzhao; Nykoluk, Mikaela; Li, Lin; Liu, Lewis R.; Omange, Robert W.; Soule, Geoff; Schroeder, Lukas T.; Toledo, Nikki; Kashem, Mohammad Abul; Correia Pinto, Jorge F.; Liang, Binhua; Schultz-Darken, Nancy; Alonso Fernández, María José; Whitney, James B.; Plummer, Francis A.; Luo, Ma (PLOS, 2017)
      Cynomolgus macaques are an increasingly important nonhuman primate model for HIV vaccine research. SIV-free animals without pre-existing anti-SIV immune responses are generally needed to evaluate the effect of vaccine-induced ...
    • A new potential nano-oncological therapy based on polyamino acid nanocapsules 

      Gonzalo, Teresa; Lollo, Giovanna; García-Fuentes, Marcos; Torres, Dolores; Correa, Juan; Riguera Vega, Ricardo; Fernández Megía, Eduardo; Calvo, Pilar; Avilés, Pablo; Guillén, Maria José; Alonso Fernández, María José (Elsevier, 2013-07)
      A critical objective in cancer therapy is to reduce the systemic toxicity through the modification of the biodistribution of anticancer drugs. Herein, we disclose a new biodegradable nanocarrier, polyglutamic acid (PGA) ...
    • Novel Hyaluronic Acid-Chitosan Nanoparticles for Ocular Gene Therapy 

      Fuente Freire, María de la; Seijo Rey, María Begoña; Alonso Fernández, María José (Arvo Journals, 2008)
      purpose. Gene therapy offers a promising alternative for the treatment of ocular diseases. However, the implementation of this type of therapy is actually hampered by the lack of an efficient ocular gene delivery carrier. ...
    • A Polymer/Oil Based Nanovaccine as a Single-Dose Immunization Approach 

      Vicente Ozores, Sara; Díaz Freitas, Belén; Peleteiro Olmedo, Mercedes; Sánchez Barreiro, Alejandro; Pascual, David W.; González Fernández, África; Alonso Fernández, María José (PLOS, 2013)
      The recognized necessity for new antigen delivery carriers with the capacity to boost, modulate and prolong neutralizing immune responses prompted our approach, in which we describe a multifunctional nanocarrier consisting ...
    • Polymeric Nanocapsules for Vaccine Delivery: Influence of the Polymeric Shell on the Interaction With the Immune System 

      Peleteiro Olmedo, Mercedes; Presas, Elena; González Aramundiz, José Vicente; Sánchez Correa, Beatriz; Simón Vázquez, Rosana; Csaba, Noemi Stefania; Alonso Fernández, María José; González Fernández, África (Frontiers Media, 2018)
      The use of biomaterials and nanosystems in antigen delivery has played a major role in the development of novel vaccine formulations in the last few decades. In an effort to gain a deeper understanding of the interactions ...
    • Polysaccharide nanoparticles can efficiently modulate the immune response against anHIV peptide antigen 

      Gómez Dacoba, Tamara; Omange, Robert W.; Li, Hongzhao; Crecente Campo, José; Luo, Ma; Alonso Fernández, María José (American Chemical Society, 2019)
      The development of an effective HIV vaccine continues to be a major health challenge since, so far, only the RV144 trial has demonstrated a modest clinical efficacy. Recently, the targeting of the 12 highly conserved ...
    • Rational design of polyarginine nanocapsules intended to help peptides overcoming intestinal barriers 

      Niu, Zhigao; Tedesco, Erik; Benetti, Federico; Mabondzo, Aloïse; Montagner, Isabella Monia; Marigo, Ilaria; González Touceda, David; Tovar Carro, Sulay A.; Diéguez González, Carlos; Santander Ortega, Manuel J.; Alonso Fernández, María José (Elsevier, 2017)
      The aim of this work was to rationally design and characterize nanocapsules (NCs) composed of an oily core and a polyarginine (PARG) shell, intended for oral peptide delivery. The cationic polyaminoacid, PARG, and the oily ...
    • Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs 

      Cadete, Ana; Olivera, Ana; Besev, Magnus; Dhal, Pradeep; Gonçalves, Lídia; Almeida, António J.; Bastiat, Guillaume; Benoit, Jean-Pierre; Fuente, María de la; García Fuentes, Marcos; Alonso Fernández, María José; Torres López, María Dolores Ramona (Nature Publishing Group, 2019)
      Preparation of sophisticated delivery systems for nanomedicine applications generally involve multi-step procedures using organic solvents. In this study, we have developed a simple self-assembling process to prepare ...
    • Synthetic nanocarriers for the delivery of polynucleotides to the eye 

      Mendes Saraiva, Sofia; Castro López, Vanessa; Pañeda Vázquez-Prada, Covadonga; Alonso Fernández, María José (Elsevier, 2017-05-30)
      This review is a comprehensive analysis of the progress made so far on the delivery of polynucleotide-based therapeutics to the eye, using synthetic nanocarriers. Attention has been addressed to the capacity of different ...
    • Technological challenges in the preclinical development of an HIV nanovaccine candidate 

      Gómez Dacoba, Tamara; Ruiz Gatón, Luisa; Benito, Ana; Klein, Marlène; Dupin, Damien; Luo, Ma; Menta, Mathieu; Teijeiro Osorio, Desirée; Loinaz, Iraida; Alonso Fernández, María José; Crecente Campo, José (BMC, 2020)
      Despite a very active research in the field of nanomedicine, only a few nano-based drug delivery systems have reached the market. The “death valley” between research and commercialization has been partially attributed to ...





      Harvesters:Interesting links:
      Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contact Us | Send Feedback