Browsing FTF-Artigos by Author "b3ae38da-6812-47f8-a142-f4cf266e805a"
Now showing items 1-2 of 2
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Prediction of multi-target networks of neuroprotective compounds with entropy indices and synthesis, assay, and theoretical study of new asymmetric 1,2-rasagiline carbamates
Romero Durán, Francisco Javier; Alonso Sousa, Nerea; Caamaño Santos, María Olga; García Mera, Xerardo Xusto; Yañez Jato, Matilde; Prado Prado, Francisco Javier; González Díaz, Humberto (MDPI, 2014)In a multi-target complex network, the links (Lij) represent the interactions between the drug (di) and the target (tj), characterized by different experimental measures (Ki, Km, IC50, etc.) obtained in pharmacological ... -
Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B
Meleddu, Rita; Distinto, Simona; Cirilli, Roberto; Alcaro, Stefano; Yañez Jato, Matilde; Sanna, María Luisa; Corona, Ángela; Melis, Claudia; Bianco, Giulia; Matyus, Peter; Cottiglia, Filippo; Maccioni, Elias (Taylor & Francis, 2017)3,5-Diaryl-4,5-dihydroisoxazoles were synthesized and evaluated as monoamine oxidase (MAO) enzyme inhibitors and iron chelators. All compounds exhibited selective inhibitory activity towards the B isoform of MAO in the ...