Now showing items 1-5 of 5

    • Co-delivery of RNAi and Chemokine by Polyarginine Nanocapsules Enables the Modulation of Myeloid-Derived Suppressor Cells 

      Martínez Ledo, Adriana; Sasso, Maria A.; Bronte, Vincenzo; Marigo, Ilaria; Boyd, Ben J.; García Fuentes, Marcos; Alonso Fernández, María José (Elsevier, 2019)
      Myeloid-Derived Suppressor Cells (MDSCs), immunosuppressive cells that promote tumor growth, represent an attractive target in cancer immunotherapy. However, the clinical success of this strategy is limited by the lack of ...
    • Extracellular matrix mechanics regulate transfection and SOX9-directed differentiation of mesenchymal stem cells 

      Martínez Ledo, Adriana; Vining, Kyle H.; Alonso Fernández, María José; García Fuentes, Marcos; Mooney, David J. (Elsevier, 2020)
      Gene delivery within hydrogel matrices can potentially direct mesenchymal stem cells (MSCs) towards a chondrogenic fate to promote regeneration of cartilage. Here, we investigated whether the mechanical properties of the ...
    • mRNA-activated matrices encoding transcription factors as primers of cell differentiation in tissue engineering 

      Martínez Ledo, Adriana; Senra, Ana; Rilo Álvarez, Héctor; Borrajo Alonso, Erea; Vidal Figueroa, Anxo; Alonso Fernández, María José; García Fuentes, Marcos (Elsevier, 2020)
      Gene-activated matrices (GAMs) encoding pivotal transcription factors (TFs) represent a powerful tool to direct stem cell specification for tissue engineering applications. However, current TF-based GAMs activated with ...
    • A new potential nano-oncological therapy based on polyamino acid nanocapsules 

      Gonzalo, Teresa; Lollo, Giovanna; García-Fuentes, Marcos; Torres, Dolores; Correa, Juan; Riguera Vega, Ricardo; Fernández Megía, Eduardo; Calvo, Pilar; Avilés, Pablo; Guillén, Maria José; Alonso Fernández, María José (Elsevier, 2013-07)
      A critical objective in cancer therapy is to reduce the systemic toxicity through the modification of the biodistribution of anticancer drugs. Herein, we disclose a new biodegradable nanocarrier, polyglutamic acid (PGA) ...
    • Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs 

      Cadete, Ana; Olivera, Ana; Besev, Magnus; Dhal, Pradeep; Gonçalves, Lídia; Almeida, António J.; Bastiat, Guillaume; Benoit, Jean-Pierre; Fuente, María de la; García Fuentes, Marcos; Alonso Fernández, María José; Torres López, María Dolores Ramona (Nature Publishing Group, 2019)
      Preparation of sophisticated delivery systems for nanomedicine applications generally involve multi-step procedures using organic solvents. In this study, we have developed a simple self-assembling process to prepare ...

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