Browsing FTF-Artigos by Author "d86370c8-53f6-4a65-94a3-9f14763fc2dd"
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Antioxidant and neuroprotective potential of the Brown Seaweed Bifurcaria bifurcata in an in vitro Parkinson’s disease model
Silva, Joana M.; Alves, Celso; Freitas, Rafaela; Martins, Alice; Pinteus, Susete; Ribeiro, Joana; Gaspar, Helena; Alfonso Rancaño, María Amparo; Pedrosa, Rui (MDPI, 2019)Bifurcaria bifurcata is a marine brown seaweed mainly found on the Atlantic coast. Herein, we report the antioxidant and neuroprotective activities of seven fractions (F1–F7) obtained by normal phase chromatography from ... -
Bromotryptamine and Bromotyramine Derivatives from the Tropical Southwestern Pacific Sponge Narrabeena nigra
Miguel Gordo, María; Gegunde Mosquera, Sandra; Calabro, Kevin; Jennings, Laurence K.; Alfonso Rancaño, María Amparo; Genta-Jouve, Grégory; Vacelet, Jean; Botana López, Luis Miguel; Thomas, Olivier P. (MDPI, 2019)So far, the Futuna Islands located in the Central Indo-Pacific Ocean have not been inventoried for their diversity in marine sponges and associated chemical diversity. As part of the Tara Pacific expedition, the first ... -
Combined Effect of Caspase-Dependent and Caspase-Independent Apoptosis in the Anticancer Activity of Gold Complexes with Phosphine and Benzimidazole Derivatives
Rouco Méndez, Lara; Sánchez González, María Ángeles; Alvariño Romero, Rebeca; Alfonso Rancaño, María Amparo; Vázquez López, Ezequiel M.; García Martínez, Emilia; Maneiro Maneiro, Marcelino (MDPI, 2021)Since the potential anticancer activity of auranofin was discovered, gold compounds have attracted interest with a view to developing anticancer agents that follow cytotoxic mechanisms other than cisplatin. Two benzimidazole ... -
Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions
Gegunde Mosquera, Sandra; Alfonso Rancaño, María Amparo; Alvariño Romero, Rebeca; Alonso López, Eva; Botana López, Luis Miguel (Frontiers Media, 2021)Cyclophilins (Cyps) are a group of peptidyl-prolyl cis/trans isomerases that play crucial roles in regulatory mechanisms of cellular physiology and pathology in several inflammatory conditions. Their receptor, CD147, also ... -
Cytotoxic Mechanism of Sphaerodactylomelol, an Uncommon Bromoditerpene Isolated from Sphaerococcus coronopifolius
Alves, Celso; Silva, Joana M.; Pinteus, Susete; Alonso López, Eva; Alvariño Romero, Rebeca; Duarte, Adriana; Marmitt, Diorge; Goettert, Márcia Inês; Gaspar, Helena; Alfonso Rancaño, María Amparo; Alpoim, Maria C.; Botana López, Luis Miguel; Pedrosa, Rui (MDPI, 2021)Marine natural products have exhibited uncommon chemical structures with relevant antitumor properties highlighting their potential to inspire the development of new anticancer agents. The goal of this work was to study ... -
Detection of Anatoxin-a and Three Analogs in Anabaena spp. Cultures: New Fluorescence Polarization Assay and Toxin Profile by LC-MS/MS
Sánchez Salguero, Jon Andoni; Otero Fuertes, María Paz; Alfonso Rancaño, María Amparo; Ramos, Vitor; Vasconcelos, Vitor; Aráoz, Romulo; Molgó, Jordi; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (MDPI, 2014)Anatoxin-a (ATX) is a potent neurotoxin produced by several species of Anabaena spp. Cyanobacteria blooms around the world have been increasing in recent years; therefore, it is urgent to develop sensitive techniques that ... -
Evaluation of the impact of mild steaming and heat treatment on the concentration of okadaic acid, dinophysistoxin-2 and dinophysistoxin-3 in mussels
Rodríguez Filgueiras, Inés; Alfonso Rancaño, María Amparo; Antelo Queijo, Álvaro; Álvarez, Mercedes; Botana López, Luis Miguel (MDPI, 2016-06)This study explores the effect of laboratory and industrial steaming on mussels with toxin concentrations above and below the legal limit. We used mild conditions for steaming, 100 ˝C for 5 min in industrial processing, ... -
First Detection of Tetrodotoxin in Greek Shellfish by UPLC-MS/MS Potentially Linked to the Presence of the Dinoflagellate Prorocentrum minimum
Vlamis, Aristidis; Katikou, Panagiota; Rodríguez Filgueiras, Inés; Rey López, Verónica; Alfonso Rancaño, María Amparo; Papazachariou, Angelos; Zacharaki, Thetis; Botana López, Ana María; Botana López, Luis Miguel (MDPI, 2015)During official shellfish control for the presence of marine biotoxins in Greece in year 2012, a series of unexplained positive mouse bioassays (MBA) for lipophilic toxins with nervous symptomatology prior to mice death ... -
First Report of Ciguatoxins in Two Starfish Species: Ophidiaster ophidianus and Marthasterias glacialis
Silva, Marisa; Rodríguez Filgueiras, Inés; Barreiro, Aldo; Kaufmann, Manfred; Neto, Ana Isabel; Hassouani, Meryem; Sabour, Brahim; Alfonso Rancaño, María Amparo; Botana López, Luis Miguel; Vasconcelos, Vitor (MDPI, 2015)Ciguatera fish poisoning (CFP) is a syndrome caused by the ingestion of fish contaminated with Ciguatoxins (CTXs). These phycotoxins are produced mainly by dinoflagellates that belong to the genus Gambierdiscus that are ... -
High serum cyclophilin C levels as a risk factor marker for coronary artery disease
Alfonso Rancaño, María Amparo; Bayón Lorenzo, Jeremías; Gegunde Mosquera, Sandra; Alonso López, Eva; Alvariño Romero, Rebeca; Santás Álvarez, Melisa; Testa Fernández, Ana; Ríos Vázquez, Ramón; González Juanatey, Carlos; Botana López, Luis Miguel (Nature Publishing Group, 2019)Cyclophilins (Cyps) are ubiquitous proteins that belong to the immunophilins family consistently associated with infammatory and cardiovascular diseases. While levels of CypA have been extensively studied, less data are ... -
How Safe Is Safe for Marine Toxins Monitoring?
Botana López, Luis Miguel; Alfonso Rancaño, María Amparo; Rodríguez Filgueiras, Inés; Botana López, Ana María; Louzao Ojeda, María Carmen; Rodríguez Vieytes, María Mercedes (MDPI AG, 2016-07-06)Current regulation for marine toxins requires a monitoring method based on mass spectrometric analysis. This method is pre-targeted, hence after searching for pre-assigned masses, it identifies those compounds that were ... -
Influence of Different Shellfish Matrices on the Separation of PSP Toxins Using a Postcolumn Oxidation Liquid Chromatography Method
Rey López, Verónica; Alfonso Rancaño, María Amparo; Botana López, Luis Miguel; Botana López, Ana María (MDPI, 2015)The separation of PSP toxins using liquid chromatography with a post-column oxidation fluorescence detection method was performed with different matrices. The separation of PSP toxins depends on several factors, and it is ... -
Natural Approaches for Neurological Disorders—The Neuroprotective Potential of Codium tomentosum
Silva, Joana M.; Martins, Alice; Alves, Celso; Pinteus, Susete; Gaspar, Helena; Alfonso Rancaño, María Amparo; Pedrosa, Rui (MDPI, 2020)Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and is characterized by a progressive degeneration of the dopaminergic neurons in the substantianigra. Although not completely understood, ... -
Neuroprotective effects of fluorophore-labelled manganese complexes: determination of ROS production, mitochondrial membrane potential and confocal fluorescence microscopy studies in neuroblastoma cells
Rouco Méndez, Lara; Alvariño Romero, Rebeca; Alfonso Rancaño, María Amparo; Romero Castro, María José; Pedrido Castiñeiras, Rosa María; Maneiro Maneiro, Marcelino (Elsevier, 2022)In this work, four manganese(II) complexes derived from the ligands H2L1-H2L4, that incorporate dansyl or tosyl fluorescent dyes, have been investigated in term of their antioxidant properties. Two of the manganese(II) ... -
New Gastropod Vectors and Tetrodotoxin Potential Expansion in Temperate Waters of the Atlantic Ocean
Silva, Marisa; Azevedo, Joana; Rodríguez Villamayor, Paula; Alfonso Rancaño, María Amparo; Botana López, Luis Miguel; Vasconcelos, Vitor (MDPI, 2012)Tetrodotoxin is a potent low weight marine toxin found in warm waters, especially of the Indian and Pacific Oceans. Intoxications are usually linked to the consumption of the puffer fish, although TTX was already detected ... -
New Invertebrate Vectors for PST, Spirolides and Okadaic Acid in the North Atlantic
Silva, Marisa; Barreiro, Aldo; Rodríguez Villamayor, Paula; Otero Fuertes, María Paz; Azevedo, Joana; Alfonso Rancaño, María Amparo; Botana López, Luis Miguel; Vasconcelos, Vitor (MDPI, 2013)The prevalence of poisoning events due to harmful algal blooms (HABs) has declined during the last two decades through monitoring programs and legislation, implemented mainly for bivalves. However, new toxin vectors and ... -
New Invertebrate Vectors of Okadaic Acid from the North Atlantic Waters—Portugal (Azores and Madeira) and Morocco
Silva, Marisa; Rodríguez Filgueiras, Inés; Barreiro, Aldo; Kaufmann, Manfred; Neto, Ana Isabel; Hassouani, Meryem; Sabour, Brahim; Alfonso Rancaño, María Amparo; Botana López, Luis Miguel; Vasconcelos, Vitor (MDPI, 2015)Okadaic acid and its analogues are potent phosphatase inhibitors that cause Diarrheic Shellfish Poisoning (DSP) through the ingestion of contaminated shellfish by humans. This group of toxins is transmitted worldwide but ... -
Occurrence of mycotoxins and mycotoxigenic fungi in silage from the north of Portugal at feed-out
González Jartín, Jesús María; Ferreiroa Martínez, Vanesa; Rodríguez Cañás, Inés; Alfonso Rancaño, María Amparo; Sainz Osés, María Jesús; Aguín Casal, Olga María; Rodríguez Vieytes, María Mercedes; Gomes, Ana; Ramos, Isabel; Botana López, Luis Miguel (Elsevier, 2022)Maize and grass silages are important dietary components for ruminant livestock that influence the quality of animal products for human consumption, such as milk, in many parts of the world. Infection of plants by fungi ... -
Oral Toxicity of Okadaic Acid in Mice: Study of Lethality, Organ Damage, Distribution and Effects on Detoxifying Gene Expression
Crespo Vieira, Andrés; Rubiolo Gaytán, Juan Andrés; López Alonso, Henar; Cifuentes Martínez, José Manuel; Alfonso Rancaño, María Amparo; Bermúdez Pose, Roberto; Otero Fuertes, María Paz; Rodríguez Vieytes, María Mercedes; Vega Lisi, Félix Víctor; Botana López, Luis Miguel (MDPI, 2013)In vivo, after administration by gavage to mice and rats, okadaic acid has been reported to produce lesions in liver, small intestine and forestomach. Because several reports differ in the damage detected in different ... -
Single and combined effects of regulated and emerging mycotoxins on viability and mitochondrial function of SH-SY5Y cells
Pérez Fuentes, Nadia; Alvariño Romero, Rebeca; Alfonso Rancaño, María Amparo; González Jartín, Jesús María; Gegunde Mosquera, Sandra; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (Elsevier, 2021)Co-occurrence of emerging and regulated mycotoxins in contaminated samples has been widely documented, but studies about their combined toxicity are scarce. In this report, the regulated mycotoxins deoxynivalenol, fumonisin ...