Now showing items 1-20 of 99

    • Novel Hyaluronic Acid-Chitosan Nanoparticles for Ocular Gene Therapy 

      Fuente Freire, María de la; Seijo Rey, María Begoña; Alonso Fernández, María José (Arvo Journals, 2008)
      purpose. Gene therapy offers a promising alternative for the treatment of ocular diseases. However, the implementation of this type of therapy is actually hampered by the lack of an efficient ocular gene delivery carrier. ...
    • Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins 

      Sobrinho, José Lamartine Soares; Soares, Mônica Felts de La Roca; Torres Labandeira, Santiago; Alves, Lariza Darlene Santos; Neto, Pedro José Rolim (Sociedade Brasileira de Química, 2011)
      This study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were ...
    • Exploring the efficiency of gallic acid-based dendrimers and their block copolymers with PEG as gene carriers 

      Fuente Freire, María de la; Raviña Fernández, Manuela; Sousa Hervés, Ana; Correa, Juan; Riguera Vega, Ricardo; Fernández Megía, Eduardo; Sánchez Barreiro, Alejandro; Alonso Fernández, María José (Future Science, 2012-07-20)
      The synthesis of a new family of amino-functionalized gallic acid-triethylene glycol (GATG) dendrimers and their block copolymers with polyethylene glycol (PEG) has recently being disclosed. In addition, these dendrimers ...
    • A Polymer/Oil Based Nanovaccine as a Single-Dose Immunization Approach 

      Vicente Ozores, Sara; Díaz Freitas, Belén; Peleteiro Olmedo, Mercedes; Sánchez Barreiro, Alejandro; Pascual, David W.; González Fernández, África; Alonso Fernández, María José (PLOS, 2013)
      The recognized necessity for new antigen delivery carriers with the capacity to boost, modulate and prolong neutralizing immune responses prompted our approach, in which we describe a multifunctional nanocarrier consisting ...
    • Surface Plasmon Resonance Biosensor Method for Palytoxin Detection Based on Na+,K+-ATPase Affinity 

      Alfonso Rancaño, María Amparo; Pazos Guldrís, María José; Fernández Araujo, Andrea; Tobío Ageitos, Araceli; Alfonso, Carmen; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (MDPI, 2013)
      Palytoxin (PLTX), produced by dinoflagellates from the genus Ostreopsis was first discovered, isolated, and purified from zoanthids belonging to the genus Palythoa. The detection of this toxin in contaminated shellfish is ...
    • A new potential nano-oncological therapy based on polyamino acid nanocapsules 

      Gonzalo, Teresa; Lollo, Giovanna; García-Fuentes, Marcos; Torres, Dolores; Correa, Juan; Riguera Vega, Ricardo; Fernández Megía, Eduardo; Calvo, Pilar; Avilés, Pablo; Guillén, Maria José; Alonso Fernández, María José (Elsevier, 2013-07)
      A critical objective in cancer therapy is to reduce the systemic toxicity through the modification of the biodistribution of anticancer drugs. Herein, we disclose a new biodegradable nanocarrier, polyglutamic acid (PGA) ...
    • Prediction of multi-target networks of neuroprotective compounds with entropy indices and synthesis, assay, and theoretical study of new asymmetric 1,2-rasagiline carbamates 

      Romero Durán, Francisco Javier; Alonso Sousa, Nerea; Caamaño Santos, María Olga; García Mera, Xerardo Xusto; Yañez Jato, Matilde; Prado Prado, Francisco; González Díaz, Humberto (MDPI, 2014)
      In a multi-target complex network, the links (Lij) represent the interactions between the drug (di) and the target (tj), characterized by different experimental measures (Ki, Km, IC50, etc.) obtained in pharmacological ...
    • Chitosan-Poly (I:C)-PADRE Based Nanoparticles as Delivery Vehicles for Synthetic Peptide Vaccines 

      Correia Pinto, Jorge F.; Csaba, Noemi Stefania; Schiller, John T.; Alonso Fernández, María José (MDPI, 2015)
      The safety and precision of peptide antigens has prompted the search for adjuvants capable of increasing the immune response against these intrinsically poorly immunogenic antigens. The integration of both immunostimulants ...
    • New insights into the causes of human illness due to consumption of azaspiracid contaminated shellfish 

      Chevallier, O. P.; Graham, S. F.; Alonso, E.; Duffy, C.; Silke, J.; Campbell, K.; Botana López, Luis Miguel; Elliott, C. T. (Nature Publishing Group, 2015)
      Azaspiracid (AZA) poisoning was unknown until 1995 when shellfish harvested in Ireland caused illness manifesting by vomiting and diarrhoea. Furtherin vivo/vitro studies showed neurotoxicity linked with AZA exposure. ...
    • Polysaccharide-based aerogel microspheres for oral drug delivery 

      García González, Carlos Alberto; Jin, Ming; Gerth, J.; Álvarez Lorenzo, Carmen Isabel; Smirnova, I. (Elsevier, 2015-03-06)
      Polysaccharide-based aerogels in the form of microspheres were investigated as carriers of poorly water soluble drugs for oral administration. These bio-based carriers may combine the biocompatibility of polysaccharides ...
    • Determination of Gonyautoxin-4 in Echinoderms and Gastropod Matrices by Conversion to Neosaxitoxin Using 2-Mercaptoethanol and Post-Column Oxidation Liquid Chromatography with Fluorescence Detection 

      Silva, Marisa; Rey López, Verónica; Botana López, Ana María; Vasconcelos, Vitor; Botana López, Luis Miguel (MDPI, 2015-12-30)
      Paralytic Shellfish Toxin blooms are common worldwide, which makes their monitoring crucial in the prevention of poisoning incidents. These toxins can be monitored by a variety of techniques, including mouse bioassay, ...
    • Yessotoxin, a promising therapeutic tool 

      Alfonso Rancaño, María Amparo; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (MDPI, 2016-01-28)
      Yessotoxin (YTX) is a polyether compound produced by dinoflagellates and accumulated in filter feeding shellfish. No records about human intoxications induced by this compound have been published, however it is considered ...
    • Heart Alterations after Domoic Acid Administration in Rats 

      Crespo Vieira, Andrés; Cifuentes Martínez, José Manuel; Bermúdez Pose, Roberto; Fernández Ferreiro, Sara; Román Castro, Albina; Botana López, Luis Miguel (MDPI AG, 2016-03-10)
      Domoic acid (DA) is one of the best known marine toxins, causative of important neurotoxic alterations. DA effects are documented both in wildlife and experimental assays, showing that this toxin causes severe injuries ...
    • Effects of Brassicaceae Isothiocyanates on Prostate Cancer 

      Novío Mallón, Silvia; CARTEA, ELENA; Soengas, Pilar; Freire Garabal, Manuel; Núñez-Iglesias, María Jesús (MDPI, 2016-05-12)
      Despite the major progress made in the field of cancer biology, cancer is still one of the leading causes of mortality, and prostate cancer (PCa) is one of the most encountered malignancies among men. The effective management ...
    • Evaluation of the impact of mild steaming and heat treatment on the concentration of okadaic acid, dinophysistoxin-2 and dinophysistoxin-3 in mussels 

      Rodríguez Filgueiras, Inés; Alfonso Rancaño, María Amparo; Antelo Queijo, Álvaro; Álvarez, Mercedes; Botana López, Luis Miguel (Multidisciplinary Digital Publishing Institute (MDPI), 2016-06)
      This study explores the effect of laboratory and industrial steaming on mussels with toxin concentrations above and below the legal limit. We used mild conditions for steaming, 100 ˝C for 5 min in industrial processing, ...
    • How Safe Is Safe for Marine Toxins Monitoring? 

      Botana López, Luis Miguel; Alfonso Rancaño, María Amparo; Rodríguez Filgueiras, Inés; Botana López, Ana María; Louzao Ojeda, María Carmen; Rodríguez Vieytes, María Mercedes (MDPI AG, 2016-07-06)
      Current regulation for marine toxins requires a monitoring method based on mass spectrometric analysis. This method is pre-targeted, hence after searching for pre-assigned masses, it identifies those compounds that were ...
    • Evaluation of the antioxidant activity of the marine pyrroloiminoquinone makaluvamines 

      Alonso López, Eva; Alvariño Romero, Rebeca; Leirós Villalba, Marta; Tabudravu, Jioji N.; Feussner, Klaus; Dam, Miriam A.; Rateb, Mostafa E.; Jaspars, Marcel; Botana López, Luis Miguel (Multidisciplinary Digital Publishing Institute (MDPI), 2016-10)
      Makaluvamines are pyrroloiminoquinones isolated from Zyzzya sponges. Until now, they have been described as topoisomerase II inhibitors with cytotoxic effects in diverse tumor cell lines. In the present work, seven ...
    • Yessotoxin, a Marine Toxin, Exhibits AntiAllergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model 

      Tobío Ageitos, Araceli; Alfonso Rancaño, María Amparo; Madera-Salcedo, Iris K.; Botana López, Luis Miguel; Blank, Ulrich (PLOS, 2016-12-14)
      Yessotoxins (YTXs) are a group of marine toxins produced by the dinoflagellates Protoceratium reticulatum, Lingulodinium polyedrum and Gonyaulax spinifera. They may have medical interest due to their potential role as ...
    • Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool 

      Cabezas Sáinz, Pablo; Guerra Varela, Jorge; Carreira Nouche, María José; Mariscal Ávila, Javier; Roel Sánchez, María; Rubiolo Gaytán, Juan Andrés; Rubiolo Gaytán, Juan Andrés; Sciara, Andrés A.; Abal Posada, Miguel; Botana López, Luis Miguel; López López, Rafael; Sánchez Piñón, Laura Elena (Springer Nature, 2017)
      Background Zebrafish (Danio rerio) is a model organism that has emerged as a tool for cancer research, cancer being the second most common cause of death after cardiovascular disease for humans in the developed world. ...
    • Computer-Assisted Recovery of Threatened Plants: Keys for Breaking Seed Dormancy of Eryngium viviparum 

      Ayuso, Manuel; Ramil Rego, Pablo; Landín Pérez, Mariana; Gallego, Pedro P.; Barreal, M. Esther (Frontiers Media, 2017)
      Many endangered plants such as Eryngium viviparum (Apiaceae) present a poor germination rate. This fact could be due to intrinsic and extrinsic seed variability influencing germination and dormancy of seeds. The objective ...





      Harvesters:Interesting links:
      Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contact Us | Send Feedback