Now showing items 1-20 of 99

    • 3D printed pellets (miniprintlets): A novel, multi-drug, controlled release platform technology 

      Awad, Atheer; Fina, Fabrizio; Trenfield, Sarah J.; Patel, Pavanesh; Goyanes Goyanes, Álvaro; Gaisford, Simon; Basit, Abdul W. (MDPI, 2019)
      [ENG]Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to utilise SLS 3DP, for the ...
    • 3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients 

      Awad, Atheer; Yao, Aliya; Trenfield, Sarah J.; Goyanes Goyanes, Álvaro; Gaisford, Simon; Basit, Abdul W. (MDPI, 2020)
      Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating ...
    • 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method 

      Robles Martínez, Pamela; Xu, Xiaoyan; Trenfield, Sarah J.; Awad, Atheer; Goyanes Goyanes, Álvaro; Telford, Richard; Basit, Abdul W.; Gaisford, Simon (MDPI, 2019)
      Three-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise ...
    • 5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines 

      Toro Sazo, Miguel; Brea Floriani, José Manuel; Loza García, María Isabel; Cimadevila Fondevila, Marta; Cassels, Bruce K. (PLOS, 2019)
      The last fifteen years have seen the emergence and overflow into the drug scene of “superpotent” N-benzylated phenethylamines belonging to the “NBOMe” series, accompanied by numerous research articles. Although N-benzyl ...
    • 8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects 

      Pilar Olaya, María del; Vergel, Nadezdha Esperanza; López, Jose Luis; Viña Castelao, María Dolores (Universidade de São Paulo, 2020)
      Parkinson’s disease is a common neurodegenerative disorder. In this study, the monoamine oxidase inhibitory activity and potential anti-parkinsonian effects of 8-propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one (FCS303), a new ...
    • Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin 

      Abal Camaño, Paula; Louzao Ojeda, María Carmen; Vilariño del Río, Natalia; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (MDPI, 2019)
      Tetrodotoxin (TTX) is an extremely toxic marine compound produced by different genera of bacteria that can reach humans through ingestion mainly of pufferfish but also of other contaminated fish species, marine gastropods ...
    • Advances on the formulation of proteins using nanotechnologies 

      Santalices Ramos, Irene; Gonella, Andrea; Torres López, María Dolores Ramona; Alonso Fernández, María José (Elsevier, 2017-12)
      Therapeutic proteins and peptides are very attractive from the pharmaceutical point of view due to their high potency and selectivity. Nonetheless, their instability and low bioavailability make their adminis- tration ...
    • An Opinion Paper on Aerogels for Biomedical and Environmental Applications 

      García González, Carlos Alberto; Budtova, Tatiana; Duräes, Luisa; Erkey, Can; Gaudio, Pasquale del; Gurikov, Pavel; Koebel, Matthias; Liebner, Falk; Neagu, Monica; Smirnova, Irina (MDPI, 2019)
      Aerogels are a special class of nanostructured materials with very high porosity and tunable physicochemical properties. Although a few types of aerogels have already reached the market in construction materials, textiles ...
    • Antioxidant and neuroprotective potential of the Brown Seaweed Bifurcaria bifurcata in an in vitro Parkinson’s disease model 

      Silva, Joana M.; Alves, Celso; Freitas, Rafaela; Martins, Alice; Pinteus, Susete; Ribeiro, Joana; Gaspar, Helena; Alfonso Rancaño, María Amparo; Pedrosa, Rui (MDPI, 2019)
      Bifurcaria bifurcata is a marine brown seaweed mainly found on the Atlantic coast. Herein, we report the antioxidant and neuroprotective activities of seven fractions (F1–F7) obtained by normal phase chromatography from ...
    • Artificial intelligence applied to flavonoid data in food matrices 

      Guardado Yordi, Estela; Koelig, Raúl; Matos, Maria J.; Pérez Martínez, Amaury; Caballero, Yailé; Santana Penín, María Lourdes; Pérez Quintana, Manuel; Molina, Enrique; Uriarte Villares, Eugenio (MDPI, 2019)
      Increasing interest in constituents and dietary supplements has created the need for more efficient use of this information in nutrition-related fields. The present work aims to obtain optimal models to predict the total ...
    • Blood glutamate EAAT2-cell grabbing therapy in cerebral ischemia 

      Pérez Mato, María; Iglesias Rey, Ramón; Vieites Prado, Alba; Dopico López, Antonio; Argibay González, Bárbara; Fernández Susavila, Héctor; Silva Candal, Andrés da; Pérez Díaz, Amparo; Correa Paz, Clara; Günther, Anne; Ávila Gómez, Paulo; Loza García, María Isabel; Baumann, Arnd; Castillo Sánchez, José Antonio; Sobrino Moreiras, Tomás; Campos Pérez, Francisco (Elsevier, 2019-01)
      Background Excitatory amino acid transporter 2 (EAAT2) plays a pivotal role in glutamate clearance in the adult brain, thereby preventing excitotoxic effects. Considering the high efficacy of EAAT2 for glutamate uptake, ...
    • Bromotryptamine and Bromotyramine Derivatives from the Tropical Southwestern Pacific Sponge Narrabeena nigra 

      Miguel Gordo, María; Gegunde Mosquera, Sandra; Calabro, Kevin; Jennings, Laurence K.; Alfonso Rancaño, María Amparo; Genta-Jouve, Grégory; Vacelet, Jean; Botana López, Luis Miguel; Thomas, Olivier P. (MDPI, 2019)
      So far, the Futuna Islands located in the Central Indo-Pacific Ocean have not been inventoried for their diversity in marine sponges and associated chemical diversity. As part of the Tara Pacific expedition, the first ...
    • Chitosan-coated mesoporous MIL-100(Fe) nanoparticles as improved bio-compatible oral nanocarriers 

      Hidalgo, T.; Giménez Marqués, M.; Bellido, E.; Avila, J.; Asensio, M.C.; Salles, F.; Lozano, M.V.; Guillevic, M.; Simón Vázquez, Rosana; González Fernández, África; Serre, C.; Alonso Fernández, María José; Horcajada, P. (Springer Nature, 2017)
      Nanometric biocompatible Metal-Organic Frameworks (nanoMOFs) are promising candidates for drug delivery. Up to now, most studies have targeted the intravenous route, related to pain and severe complications; whereas nanoMOFs ...
    • Chitosan-Poly (I:C)-PADRE Based Nanoparticles as Delivery Vehicles for Synthetic Peptide Vaccines 

      Correia Pinto, Jorge F.; Csaba, Noemi Stefania; Schiller, John T.; Alonso Fernández, María José (MDPI, 2015)
      The safety and precision of peptide antigens has prompted the search for adjuvants capable of increasing the immune response against these intrinsically poorly immunogenic antigens. The integration of both immunostimulants ...
    • Chronic In Vivo Effects of Repeated Exposure to Low Oral Doses of Tetrodotoxin: Preliminary Evidence of Nephrotoxicity and Cardiotoxicity 

      Boente Juncal, Andrea; Vale González, María del Carmen; Cifuentes Martínez, José Manuel; Otero Fuertes, María Paz; Camiña García, María Mercedes; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (MDPI, 2019)
      Tetrodotoxin (TTX) is one of the most potent naturally occurring neurotoxins. Initially TTX was associated with human food intoxications in Japan, but nowadays, concerns about the human health risks posed by TTX have ...
    • Co-delivery of RNAi and Chemokine by Polyarginine Nanocapsules Enables the Modulation of Myeloid-Derived Suppressor Cells 

      Martínez Ledo, Adriana; Sasso, Maria A.; Bronte, Vincenzo; Marigo, Ilaria; Boyd, Ben J.; García Fuentes, Marcos; Alonso Fernández, María José (Elsevier, 2019)
      Myeloid-Derived Suppressor Cells (MDSCs), immunosuppressive cells that promote tumor growth, represent an attractive target in cancer immunotherapy. However, the clinical success of this strategy is limited by the lack of ...
    • Combining DOE with neurofuzzy logic for healthy mineral nutrition of pistachio rootstocks in vitro culture 

      Nezami Alanagh, Esmaeil; Garoosi, Ghasem-Ali; Landín Pérez, Mariana; Gallego, Pedro Pablo (Fontiers Media, 2018)
      The aim of this study was to determine the effects of Murashige and Skoog (MS) salts on optimal growth of two pistachio rootstocks, P. vera cv. “Ghazvini” and “UCB1” using design of experiments (DOE) and artificial ...
    • A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade 

      Izquierdo Berjano, Irene; Núñez Barrachina, María; Hermida Nogueira, Lidia; Casas, Vanessa; Morán Lara, Luis Arturo; Lacerenza, Serena; Pinto-Llorente, Roberto; Eble, Johannes A.; Ríos, Vivian de los; Domínguez Medina, Eduardo; Loza García, María Isabel; Casal, José Ignacio; Carrascal, Montserrat; Abián, Joaquín; García Alonso, Ángel (Thieme Publishing Group, 2020)
      C-type lectin-like receptor 2 (CLEC-2) plays a crucial role in different platelet-related physiological and pathological processes. It signals through a tyrosine kinase-mediated pathway that is highly dependent on the ...
    • Computer-Assisted Recovery of Threatened Plants: Keys for Breaking Seed Dormancy of Eryngium viviparum 

      Ayuso, Manuel; Ramil Rego, Pablo; Landín Pérez, Mariana; Gallego, Pedro P.; Barreal, M. Esther (Frontiers Media, 2017)
      Many endangered plants such as Eryngium viviparum (Apiaceae) present a poor germination rate. This fact could be due to intrinsic and extrinsic seed variability influencing germination and dormancy of seeds. The objective ...
    • Creme tópico de capsaicina (8%) para o tratamento da síndrome da dor miofascial 

      Romero, Valéria; Rodrigues Lara, Juliana; Otero Espinar, Francisco Javier; Salgado, Manoel Henrique; Módolo, Norma Sueli Pinheiro; Barros, Guilherme Antonio Moreira (Elsevier, 2019)
      Justificativa: A síndrome da dor miofascial é uma causa comum de dor musculoesquelética. O objetivo deste estudo foi avaliar a potencial ação analgésica de 8% do creme de capsaicina para uso tópico em pacientes com ...





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