Browsing BBM-Artigos by Title
Now showing items 11-30 of 64
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A dendrimer–hydrophobic interaction synergy improves the stability of polyion complex micelles
(Royal Society of Chemistry, 2017-03-28)Polyion complex (PIC) micelles incorporating PEG-dendritic copolymers display an unprecedented stability towards ionic strength that is amplified via hydrophobic interactions. The tridimensional orientation of peripheral ... -
Different intracellular distribution of avian reovirus core protein sigmaA in cells of avian and mammalian origin
(Elsevier, 2012)A comparative analysis of the intracellular distribution of avian reovirus (ARV) core protein sigmaA in cells of avian and mammalian origin revealed that, whereas the viral protein accumulates in the cytoplasm and nucleolus ... -
Differential inhibitor sensitivity between human kinases VRK1 and VRK2
(PLOS, 2011)Human vaccinia-related kinases (VRK1 and VRK2) are atypical active Ser-Thr kinases implicated in control of cell cycle entry, apoptosis and autophagy, and affect signalling by mitogen activated protein kinases (MAPK). The ... -
Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus
(BMC, 2014)Background: Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures. This study tested the effect of eslicarbazepine acetate ... -
Evaluation of pleural effusion sCD26 and DPP-IV as diagnostic biomarkers in lung disease
(Nature Publishing Group, 2015)In this study, we measured ADA and DPP-IV enzymatic activity and sCD26 concentration in 150 pleural effusion (PE) samples and tested for correlations between these and other cellular and biochemical measures. We found ... -
Evolución temporal del índice gonadal de los erizos marinos Paracentrotus lividus (Echinoida: Echinidae) y Diadema africanum (Diadematoida: Diadematidae) en las islas Canarias (España)
(Universidad de Costa Rica, 2015)Temporal evolution of the gonad index of the sea urchins Paracentrotus lividus (Echinoida: Echinidae) and Diadema africanum (Diadematoida: Diadematidae) in the Canary Islands (Spain). There are three main species of ... -
Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins
(Oxford University Press, 2020)The S phase checkpoint is crucial to maintain genome stability under conditions that threaten DNA replication. One of its critical functions is to prevent Exo1-dependent fork degradation, and Exo1 is phosphorylated in ... -
Expansion of different subpopulations of CD26−/low T cells in allergic and non-allergic asthmatics
(Nature Publishing Group, 2019)CD26 displays variable levels between effector (TH17 ≫ TH1 > TH2 > Treg) and naïve/memory (memory > naïve) CD4+ T lymphocytes. Besides, IL-6/IL−6R is associated with TH17-differentiation and asthma severity. Allergic/atopic ... -
Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors
(American Chemical Society, 2014)Structural and computational studies to explore the WAT1 binding pocket in the structure-based design of inhibitors against the type II dehydroquinase (DHQ2) enzyme are reported. The crystal structures of DHQ2 from M. ... -
Functional assessment of the BMPR2 gene in lymphoblastoid cell lines from Graves’ disease patients
(Wiley, 2018)In this study, we analysed the possible influence of the c.419‐43delT BMPR2 variant in patients with Graves’ disease (GD), in a molecular basis, focusing our efforts on possible alterations in the mRNA processing and ... -
High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers
(Royal Society of Chemistry, 2022)The synthesis of nanosized metal–organic frameworks (NMOFs) is requisite for their application as injectable drug delivery systems (DDSs) and other biorelevant purposes. Herein, we have critically examined the role of ... -
IC-Tagging and Protein Relocation to ARV muNS Inclusions: A Method to Study Protein-Protein Interactions in the Cytoplasm or Nucleus of Living Cells
(PLOS, 2010)Background: Characterization of protein-protein interactions is essential for understanding cellular functions. Although there are many published methods to analyze protein-protein interactions, most of them present serious ... -
IC-Tagging methodology applied to the expression of viral glycoproteins and the difficult-to-express membrane-bound IGRP autoantigen
(Springer Nature, 2018)We have previously developed a methodology to produce protein microspheres (MS) that can be loaded with proteins of interest in living cells through their C or N-terminal tagging with the so-called IC-Tag. The IC-Tagging ... -
Immunohistochemical expression of E–cadherin in different tissues of the teleost fish Scophthalmus maximus
(Elsevier, 2019)E–cadherin is an evolutionary conserved protein, whose main role as the principal component of adherens junctions is supporting epithelial cell–cell adhesion. It is an essential molecule for the maintenance of the epithelial ... -
In situ functionalized polymers for siRNA delivery
(WILEY-VCH Verlag GmbH, 2016-04-21)A new method is reported herein for screening the biological activity of functional polymers across a consistent degree of polymerization and in situ, that is, under aqueous conditions and without purification/isolation ... -
In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains
(American Chemical Society, 2012)Chemical derivatization of nucleic stains such as ethidium bromide or DAPI with tailored, photoresponsive caging groups, allows for “on demand” spatiotemporal control of their in vivo nucleic acid binding, as well as for ... -
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function
(Elsevier, 2021)Non-alcoholic fatty liver disease (NAFLD) is a major health threat in both developed and developing countries and is a precursor of the more advanced liver diseases, including non-alcoholic steatohepatitis (NASH), cirrhosis, ... -
Insights into substrate binding and catalysis in bacterial type I dehydroquinase
(Portland Press, 2014-09-15)Structural, biochemical and computational studies to study substrate binding and the role of the conserved residues of the DHQ1 (type I dehydroquinase) enzyme active site are reported in the present paper. The crystal ... -
Interferon induction by avian reovirus
(Elsevier, 2016-01)We have previously shown that the replication of avian reovirus (ARV) in chicken embryo fibroblasts (CEF) is more resistant to the antiviral action of interferon (IFN) than the replication of vesicular stomatitis virus ... -
Invasion of the dark false mussel in shrimp farms in Venezuela: species identification and genetic analysis
(Regional Euro-Asian Biological Invasions Centre (REABIC), 2019)An inspection was carried out at shrimp farms located South West of Lake Maracaibo (Zulia State, Venezuela), with high incidences of mussel bivalve. Morphological and genetic analysis helped to identify the species as ...