Now showing items 14-33 of 64

    • Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus 

      Sierra Paredes, Germán; Loureiro, Ana I.; Wright, Lyndon C.; Sierra Marcuño, Germán; Silva, Patrício Soares da (BMC, 2014)
      Background: Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures. This study tested the effect of eslicarbazepine acetate ...
    • Evaluation of pleural effusion sCD26 and DPP-IV as diagnostic biomarkers in lung disease 

      Sánchez Otero, Nuria; Rodríguez Berrocal, Francisco Javier; Páez de la Cadena, María; Botana Rial, María Isabel; Cordero Santamaría, Óscar Javier (Nature Publishing Group, 2015)
      In this study, we measured ADA and DPP-IV enzymatic activity and sCD26 concentration in 150 pleural effusion (PE) samples and tested for correlations between these and other cellular and biochemical measures. We found ...
    • Evolución temporal del índice gonadal de los erizos marinos Paracentrotus lividus (Echinoida: Echinidae) y Diadema africanum (Diadematoida: Diadematidae) en las islas Canarias (España) 

      González Henríquez, Nieves; Rey Méndez, Manuel; Catoira Gómez, José Luís; Ruíz de la Rosa, Manuel; Louzara Fernádez, Gregorio; Girard Berard, Dominique (Universidad de Costa Rica, 2015)
      Temporal evolution of the gonad index of the sea urchins Paracentrotus lividus (Echinoida: Echinidae) and Diadema africanum (Diadematoida: Diadematidae) in the Canary Islands (Spain). There are three main species of ...
    • Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins 

      Morafraile, Esther C.; Bugallo, Alberto; Carreira Rodríguez, Raquel; Fernández, María; Martín Castellanos, Cristina; González Blanco, Miguel; Segurado, Mónica (Oxford University Press, 2020)
      The S phase checkpoint is crucial to maintain genome stability under conditions that threaten DNA replication. One of its critical functions is to prevent Exo1-dependent fork degradation, and Exo1 is phosphorylated in ...
    • Expansion of different subpopulations of CD26−/low T cells in allergic and non-allergic asthmatics 

      Nieto Fontarigo, Juan José; Salgado Castro, Francisco Javier; San José Capilla, María Esther; Cruz, María Jesús; Valdés Cuadrado, Luis Guillermo; Pérez Díaz, Amparo; Arias Crespo, María Pilar; Nogueira Álvarez, Montserrat; González Barcala, Francisco Javier (Nature Publishing Group, 2019)
      CD26 displays variable levels between effector (TH17 ≫ TH1 > TH2 > Treg) and naïve/memory (memory > naïve) CD4+ T lymphocytes. Besides, IL-6/IL−6R is associated with TH17-differentiation and asthma severity. Allergic/atopic ...
    • Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors 

      Blanco Rodríguez, Beatriz; Sedes, Antía; Peón López, Antonio; Otero Casas, José Manuel; Raaij, Mark J. van; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (American Chemical Society, 2014)
      Structural and computational studies to explore the WAT1 binding pocket in the structure-based design of inhibitors against the type II dehydroquinase (DHQ2) enzyme are reported. The crystal structures of DHQ2 from M. ...
    • Functional assessment of the BMPR2 gene in lymphoblastoid cell lines from Graves’ disease patients 

      Pousada Fernández, Guillermo; Lago Docampo, Mauro; Prado López, Sonia; Varela Calviño, Rubén; Mantiñán Gil, Beatriz; Valverde Pérez, Diana (Wiley, 2018)
      In this study, we analysed the possible influence of the c.419‐43delT BMPR2 variant in patients with Graves’ disease (GD), in a molecular basis, focusing our efforts on possible alterations in the mRNA processing and ...
    • High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers 

      Ceballos Guzmán, Manuel; Cedrún-Morales, Manuela; Rodríguez Pérez, Manuel; Funes-Hernando, Samuel; Vila Fungueiriño, José Manuel; Zampini, Giulia; Polo Tobajas, Ester; Pino, Pablo del; Pelaz García, Beatriz (Royal Society of Chemistry, 2022)
      The synthesis of nanosized metal–organic frameworks (NMOFs) is requisite for their application as injectable drug delivery systems (DDSs) and other biorelevant purposes. Herein, we have critically examined the role of ...
    • IC-Tagging and Protein Relocation to ARV muNS Inclusions: A Method to Study Protein-Protein Interactions in the Cytoplasm or Nucleus of Living Cells 

      Brandariz Núñez, Alberto; Menaya Vargas, Rebeca; Benavente Martínez, Francisco Javier; Martínez Costas, José Manuel (PLOS, 2010)
      Background: Characterization of protein-protein interactions is essential for understanding cellular functions. Although there are many published methods to analyze protein-protein interactions, most of them present serious ...
    • IC-Tagging methodology applied to the expression of viral glycoproteins and the difficult-to-express membrane-bound IGRP autoantigen 

      Barreiro Piñeiro, Natalia; Lostalé Seijo, Irene; Varela Calviño, Rubén; Benavente Martínez, Francisco Javier; Martínez Costas, José Manuel (Springer Nature, 2018)
      We have previously developed a methodology to produce protein microspheres (MS) that can be loaded with proteins of interest in living cells through their C or N-terminal tagging with the so-called IC-Tag. The IC-Tagging ...
    • Immunohistochemical expression of E–cadherin in different tissues of the teleost fish Scophthalmus maximus 

      Ronza, Paolo; Villamarín Cid, José Antonio; Méndez, Lucía; Gómez Pardo, María Belén; Bermúdez Pose, Roberto; Quiroga Berdeal, María Isabel (Elsevier, 2019)
      E–cadherin is an evolutionary conserved protein, whose main role as the principal component of adherens junctions is supporting epithelial cell–cell adhesion. It is an essential molecule for the maintenance of the epithelial ...
    • In situ functionalized polymers for siRNA delivery 

      Martínez Costas, José Manuel; Fernández Trillo, Francisco; Montenegro García, Javier; Granja Guillán, Juan Ramón; Priegue Caamaño, Juan Manuel; Crisan, Daniel (WILEY-VCH Verlag GmbH, 2016-04-21)
      A new method is reported herein for screening the biological activity of functional polymers across a consistent degree of polymerization and in situ, that is, under aqueous conditions and without purification/isolation ...
    • In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains 

      Sánchez López, Mateo Isidro; Martínez Costas, José Manuel; González García, Francisco; Álvarez Bermúdez, María José; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (American Chemical Society, 2012)
      Chemical derivatization of nucleic stains such as ethidium bromide or DAPI with tailored, photoresponsive caging groups, allows for “on demand” spatiotemporal control of their in vivo nucleic acid binding, as well as for ...
    • Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function 

      Lima, Nátalia da Silva; Fernández Fondevila; Nóvoa Deaño, Eva María; Buqué, Xabier; Mercado Gómez, María; Gallet, Sarah; González Rellán, María Jesús; Fernández Paz, Uxía; Loyens, Anne; García Vence, María; Chantada Vázquez, María del Pilar; Bravo López, Susana Belén; Marañón Barnusell, Patricia; Senra Viñas, Ana; Escudero Pérez, Adriana; Leiva Arjona, Magdalena; Guallar Artal, Diana; Fidalgo Pérez, Miguel Ángel; Gomes, Pedro; Claret, Marc; Sabio Buzo, Guadalupe; Varela Rey, Marta; Cardoso Delgado, Teresa; MONTERO VALLEJO, ROCIO; Ampuero, Javier; López Pérez, Miguel Antonio; Diéguez González, Carlos; Herrero, Laura; Serra Cucurull, Dolors; Schwaninger, Markus; Prevot, Vincent; Gallego-Durán, Rocío; Romero-Gómez, Manuel; IRUZUBIETA, PAULA; Crespo García, Javier; Martinez Chantar, Maria Luz; García Monzón, Carmelo; González-Rodríguez, Águeda; Aspichueta, Patricia; Nogueiras Pozo, Rubén (Elsevier, 2021)
      Non-alcoholic fatty liver disease (NAFLD) is a major health threat in both developed and developing countries and is a precursor of the more advanced liver diseases, including non-alcoholic steatohepatitis (NASH), cirrhosis, ...
    • Insights into substrate binding and catalysis in bacterial type I dehydroquinase 

      Maneiro Rey, María; Peón López, Antonio; Lence Quintana, Emilio José; Otero Casas, José Manuel; Raaij, Mark J. van; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (Portland Press, 2014-09-15)
      Structural, biochemical and computational studies to study substrate binding and the role of the conserved residues of the DHQ1 (type I dehydroquinase) enzyme active site are reported in the present paper. The crystal ...
    • Interferon induction by avian reovirus 

      Lostalé Seijo, Irene; Martínez Costas, José Manuel; Benavente Martínez, Francisco Javier (Elsevier, 2016-01)
      We have previously shown that the replication of avian reovirus (ARV) in chicken embryo fibroblasts (CEF) is more resistant to the antiviral action of interferon (IFN) than the replication of vesicular stomatitis virus ...
    • Invasion of the dark false mussel in shrimp farms in Venezuela: species identification and genetic analysis 

      Lodeiros, Cesar; González Henríquez, Nieves; Cuéllar Anjel, Jorge; Hernández Reyes, Dailos; Medina Alcaraz, Carolina; Quinteiro Vázquez, Javier; Rey Méndez, Manuel (Regional Euro-Asian Biological Invasions Centre (REABIC), 2019)
      An inspection was carried out at shrimp farms located South West of Lake Maracaibo (Zulia State, Venezuela), with high incidences of mussel bivalve. Morphological and genetic analysis helped to identify the species as ...
    • Irreversible covalent modification of type I dehydroquinase with a stable Schiff base 

      Tizón, Lorena; Maneiro Rey, María; Peón López, Antonio; Otero Casas, José Manuel; Lence Quintana, Emilio José; Poza, Sergio; Raaij, Mark J. van; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (Royal Society of Chemistry, 2015)
      The irreversible inhibition of type I dehydroquinase (DHQ1), the third enzyme of the shikimic acid pathway, is investigated by structural, biochemical and computational studies. Two epoxides, which are mimetics of the ...
    • Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)-2-Benzyl-3-dehydroquinic Acids 

      Lence Quintana, Emilio José; Tizón, Lorena; Otero Casas, José Manuel; Peón López, Antonio; Prazeres, Verónica F. V.; Llamas Saiz, Antonio Luis; Fox, Gavin V.; Raaij, Mark J. van; Lamb, Heather; Hawkins, Alastair R.; González Bello, Concepción (American Chemical Society, 2013)
      The structural changes caused by the substitution of the aromatic moiety in (2S)-2-benzyl-3-dehydroquinic acids and its epimers in C2 by electron-withdrawing or electron-donating groups in type II dehydroquinase enzyme ...
    • Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases 

      Coderch, Claire; Lence Quintana, Emilio José; Peón López, Antonio; Lamb, Heather; Hawkins, Alastair R.; Gago, Federico; González Bello, Concepción (Portland Press, 2014-03-15)
      DHQ2 (type II dehydroquinase), which is an essential enzyme in Helicobacter pylori and Mycobacterium tuberculosis and does not have any counterpart in humans, is recognized to be an attractive target for the development ...





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