Browsing BBM-Artigos by Title
Now showing items 1-20 of 61
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Anti-CD26 autoantibodies are involved in rheumatoid arthritis and show potential clinical interest
(Elsevier, 2017-06-05)Objectives Rheumatoid arthritis (RA) patients show low serum levels of the Ag dipeptidyl peptidase IV (DPP-IV/CD26), both soluble CD26 (sCD26) concentration and its DPP-IV activity. The aim of this study was to test if ... -
Avian reovirus-triggered apoptosis enhances both virus spread and the processing of the viral nonstructural muNS protein
(Elsevier, 2014-08)Avian reovirus non-structural protein muNS is partially cleaved in infected chicken embryo fibroblast cells to produce a 55-kDa carboxyterminal protein, termed muNSC, and a 17-kDa aminoterminal polypeptide, designated ... -
Blood glutamate EAAT2-cell grabbing therapy in cerebral ischemia
(Elsevier, 2019-01)Background Excitatory amino acid transporter 2 (EAAT2) plays a pivotal role in glutamate clearance in the adult brain, thereby preventing excitotoxic effects. Considering the high efficacy of EAAT2 for glutamate uptake, ... -
CD26 Expression on T Helper Populations and sCD26 Serum Levels in Patients with Rheumatoid Arthritis
(Public Library of Science, 2015)We studied dipeptidyl peptidase IV (DPP-IV, CD26) expression in different T helper cells and serum soluble DPP-IV/sCD26 levels in rheumatoid arthritis (RA) patients, correlated these with disease activity score (DAS), and ... -
Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct
(American Chemical Society, 2015)The first example of an ammonium derivative that causes a specific modification of the active site of type I dehydroquinase (DHQ1), a dehydratase enzyme that is a promising target for antivirulence drug discovery, is ... -
Conservation of the S10-spc-alpha Locus within Otherwise Highly Plastic Genomes Provides Phylogenetic Insight into the Genus Leptospira
(PLOS, 2008)S10-spc-α is a 17.5 kb cluster of 32 genes encoding ribosomal proteins. This locus has an unusual composition and organization in Leptospira interrogans. We demonstrate the highly conserved nature of this region among ... -
Crecimiento y mejora del índice gonadal en el cultivo del erizo de mar Paracentrotus lividus (Echinoida: Echinidae) en Galicia (España)
(Universidad de Costa Rica, 2015)The high demand for Paracentrotus lividus (Lamarck, 1816) in countries like France, Italy, Turkey, Belgium and Japan, has raised the level of extraction of this echinoderm in recent years and has generated wear urchin ... -
CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
(American Society for Clinical Investigation, 2008)The final pathway of β cell destruction leading to insulin deficiency, hyperglycemia, and clinical type 1 diabetes is unknown. Here we show that circulating CTLs can kill β cells via recognition of a glucose-regulated ... -
A dendrimer–hydrophobic interaction synergy improves the stability of polyion complex micelles
(Royal Society of Chemistry, 2017-03-28)Polyion complex (PIC) micelles incorporating PEG-dendritic copolymers display an unprecedented stability towards ionic strength that is amplified via hydrophobic interactions. The tridimensional orientation of peripheral ... -
Different intracellular distribution of avian reovirus core protein sigmaA in cells of avian and mammalian origin
(Elsevier, 2012)A comparative analysis of the intracellular distribution of avian reovirus (ARV) core protein sigmaA in cells of avian and mammalian origin revealed that, whereas the viral protein accumulates in the cytoplasm and nucleolus ... -
Differential inhibitor sensitivity between human kinases VRK1 and VRK2
(PLOS, 2011)Human vaccinia-related kinases (VRK1 and VRK2) are atypical active Ser-Thr kinases implicated in control of cell cycle entry, apoptosis and autophagy, and affect signalling by mitogen activated protein kinases (MAPK). The ... -
Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus
(BMC, 2014)Background: Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures. This study tested the effect of eslicarbazepine acetate ... -
Evaluation of pleural effusion sCD26 and DPP-IV as diagnostic biomarkers in lung disease
(Nature Publishing Group, 2015)In this study, we measured ADA and DPP-IV enzymatic activity and sCD26 concentration in 150 pleural effusion (PE) samples and tested for correlations between these and other cellular and biochemical measures. We found ... -
Evolución temporal del índice gonadal de los erizos marinos Paracentrotus lividus (Echinoida: Echinidae) y Diadema africanum (Diadematoida: Diadematidae) en las islas Canarias (España)
(Universidad de Costa Rica, 2015)Temporal evolution of the gonad index of the sea urchins Paracentrotus lividus (Echinoida: Echinidae) and Diadema africanum (Diadematoida: Diadematidae) in the Canary Islands (Spain). There are three main species of ... -
Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins
(Oxford University Press, 2020)The S phase checkpoint is crucial to maintain genome stability under conditions that threaten DNA replication. One of its critical functions is to prevent Exo1-dependent fork degradation, and Exo1 is phosphorylated in ... -
Expansion of different subpopulations of CD26−/low T cells in allergic and non-allergic asthmatics
(Nature Publishing Group, 2019)CD26 displays variable levels between effector (TH17 ≫ TH1 > TH2 > Treg) and naïve/memory (memory > naïve) CD4+ T lymphocytes. Besides, IL-6/IL−6R is associated with TH17-differentiation and asthma severity. Allergic/atopic ... -
Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors
(American Chemical Society, 2014)Structural and computational studies to explore the WAT1 binding pocket in the structure-based design of inhibitors against the type II dehydroquinase (DHQ2) enzyme are reported. The crystal structures of DHQ2 from M. ... -
Functional assessment of the BMPR2 gene in lymphoblastoid cell lines from Graves’ disease patients
(Wiley, 2018)In this study, we analysed the possible influence of the c.419‐43delT BMPR2 variant in patients with Graves’ disease (GD), in a molecular basis, focusing our efforts on possible alterations in the mRNA processing and ... -
IC-Tagging and Protein Relocation to ARV muNS Inclusions: A Method to Study Protein-Protein Interactions in the Cytoplasm or Nucleus of Living Cells
(PLOS, 2010)Background: Characterization of protein-protein interactions is essential for understanding cellular functions. Although there are many published methods to analyze protein-protein interactions, most of them present serious ...