• Deactivation of a dimeric DNA-binding peptide through a palladium-mediated self-immolative cleavage 

  Rodríguez Villar, Jéssica; Pérez González, Cibrán; Martínez Calvo, Miguel; Mosquera Mosquera, Jesús; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2022)

  Herein, we describe an approach for the on-demand disassembly of dimeric peptides using a palladium-mediated cleavage of a designed self-immolative linker. The utility of the strategy is demonstrated for the case of dimeric ...

• (4 + 2) Cycloadditions via Pd C(sp3 )–H activation 

  Vidal Pereira, Xandro; Font Molíns, Marc; Cendón Mariño, Borja; Mascareñas Cid, José Luis; Gulías Costa, Moisés (Elsevier, 2021)

  The functionalization of aliphatic C (sp3)-H bonds using Pd catalysis has emerged as a powerful, step economical methodology for the construction of C–C and C–X bonds. Despite the progress in this field, examples of formal ...

• Pd-Catalyzed Allylic C-H Activation to Seven-Membered N,O-Heterocycles 

  Velasco Rubio, Álvaro; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (Royal Society of Chemistry, 2021)

  Pd-catalyzed allylic C-H activation of simple olefins allows an easy entry to seven-membered N,O-heterocycles such as 1,4-benzoxazepines (1,4-BZOs), 1,4-benzodiazepinones (1,4-BZDs) and 1,4-oxazepanes in good to excellent ...

• Plasmonic-assisted thermocyclizations in living cells using metal−organic framework based nanoreactors 

  Carrillo Carrión, Carolina; Martínez González, Raquel; Polo Tobajas, Ester; Tomás Gamasa, María; Destito, Paolo; Ceballos, Manuel; Pelaz García, Beatriz; López García, Fernando; Mascareñas Cid, José Luis; Pino, Pablo del (ACS, 2021)

  We describe a microporous plasmonic nanoreactor to carry out designed near-infrared (NIR)-driven photothermal cyclizations inside living cells. As a proof of concept, we chose an intramolecular cyclization that is based ...

• Liver X receptor activation with an intranasal polymer therapeutic prevents cognitive decline without altering lipid levels 

  Navas Guimaraes, María Eugenia; López Blanco, Roi; Correa Chinea, Juan Francisco; Fernández Villamarín, Marcos; Bistué, María Beatriz; Martino Adami, Pamela; Morelli, Laura; Kumar, Vijay; Wempe, Michael F.; Cuello, A. Claudio; Fernández Megía, Eduardo; Bruno, Martín Alejandro (ACS, 2021)

  The progressive accumulation of amyloid-beta (Aβ) in specific areas of the brain is a common prelude to late-onset of Alzheimer’s disease (AD). Although activation of liver X receptors (LXR) with agonists decreases Aβ ...

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