QO-Artigos
Browse by
Recent Submissions
-
Organometallic catalysis in aqueous and biological environments: harnessing the power of metal carbenes
(Royal Society of Chemistry, 2022)Translating the power of transition metal catalysis to the native habitats of enzymes can significantly expand the possibilities of interrogating or manipulating natural biological systems, including living cells and ... -
Palladium-Catalyzed Tandem Cycloisomerization/Cross-Coupling of Carbonyl- and Imine-Tethered Alkylidenecyclopropanes
(Wiley, 2022)A palladium catalytic system is reported for the divergent tandem cycloisomerization and cross-coupling of carbonyl- and imine-tethered alkylidenecyclopropanes (ACPs). The selection of ancillary ligands is pivotal for the ... -
Aggregation versus inclusion complexes to solubilize drugs with cyclodextrins. A case study using sulphobutylether-β-cyclodextrins and remdesivir
(Elsevier, 2021)The formation of small hybrid aggregates between excipient and drug molecules is one of the mechanisms that contributes to the solubilization of active principles in pharmaceutical formulations. The characterization of the ... -
Remdesivir interactions with sulphobutylether-β-cyclodextrins: a case study using selected substitution patterns
(Elsevier, 2022)Modified cyclodextrins (CDs) consist of a distribution of different structures with different number and location of the substituted groups. Among the most important applications of these molecules is their use as an ... -
Deactivation of a dimeric DNA-binding peptide through a palladium-mediated self-immolative cleavage
(Royal Society of Chemistry, 2022)Herein, we describe an approach for the on-demand disassembly of dimeric peptides using a palladium-mediated cleavage of a designed self-immolative linker. The utility of the strategy is demonstrated for the case of dimeric ...