Now showing items 1-5 of 5

    • Assembly of a Ternary Metallopeptide Complex at Specific DNA Sites Mediated by an AT‐Hook Adaptor 

      Learte Aymamí, Soraya; Rodríguez Villar, Jéssica; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Wiley, 2020)
      The nickel(II)‐mediated self‐assembly of a multimeric DNA binder is described. The binder is composed of two metal‐chelating peptides derived from a bZIP transcription factor (brHis2) and one short AT‐hook domain equipped ...
    • DNA-binding miniproteins based on zinc fingers. Assessment of the interaction using nanopores 

      Rodríguez Villar, Jéssica; Learte Aymamí, Soraya; Mosquera Mosquera, Jesús; Celaya, Garbiñe; Rodríguez Larrea, David; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2018)
      Obtaining artificial proteins that mimic the DNA binding properties of natural transcription factors could open new ways of manipulating gene expression at will. In this context it is particularly interesting to develop ...
    • Intracellular Reactions Promoted by Bis(histidine) Miniproteins Stapled Using Palladium(II) Complexes 

      Learte Aymamí, Soraya; Vidal Vives, Christian; Gutiérrez González, Alejandro; Mascareñas Cid, José Luis (Wiley, 2020)
      The generation of catalytically active metalloproteins inside living mammalian cells is a major research challenge at the interface between catalysis and cell biology. Herein we demonstrate that basic domains of bZIP ...
    • Metal-Dependent DNA Recognition and Cell Internalization of Designed, Basic Peptides 

      Learte Aymamí, Soraya; Curado, Natalia; Rodríguez Villar, Jéssica; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (American Chemical Society, 2017)
      A fragment of the DNA basic region (br) of the GCN4 bZIP transcription factor has been modified to include two His residues at designed i and i+4 positions of its N-terminus. The resulting monomeric peptide (brHis2) does ...
    • Stimuli-Responsive DNA Binding by Synthetic Systems 

      Rodríguez Villar, Jéssica; Mosquera Mosquera, Jesús; Learte Aymamí, Soraya; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (American Chemical Society, 2020)
      Conspectus: DNA is the molecule responsible for the storage and transmission of the genetic information in living organisms. The expression of this information is highly regulated. In eukaryotes, it is achieved mainly at ...





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