Now showing items 1-11 of 11

    • Custom‐Fit Ruthenium(II) Metallopeptides: A New Twist to DNA Binding With Coordination Compounds 

      Gamba, Ilaria; Salvadó, Iria; Rama, Gustavo; Bertazzon, Miriam; Sánchez López, Mateo Isidro; Sánchez-Pedregal, Víctor M.; Martínez Costas, José Manuel; Brissos, Rosa F.; Gamez, Patrick; Mascareñas Cid, José Luis; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Wiley, 2013)
    • A dendrimer–hydrophobic interaction synergy improves the stability of polyion complex micelles 

      Fernández Villamarín, Marcos; Sousa Hervés, Ana; Porto, Silvia; Guldris, Noelia; Martínez Costas, José Manuel; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Royal Society of Chemistry, 2017-03-28)
      Polyion complex (PIC) micelles incorporating PEG-dendritic copolymers display an unprecedented stability towards ionic strength that is amplified via hydrophobic interactions. The tridimensional orientation of peripheral ...
    • In situ functionalized polymers for siRNA delivery 

      Martínez Costas, José Manuel; Fernández Trillo, Francisco; Montenegro García, Javier; Granja Guillán, Juan Ramón; Priegue Caamaño, Juan Manuel; Crisan, Daniel (WILEY-VCH Verlag GmbH, 2016-04-21)
      A new method is reported herein for screening the biological activity of functional polymers across a consistent degree of polymerization and in situ, that is, under aqueous conditions and without purification/isolation ...
    • In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains 

      Sánchez López, Mateo Isidro; Martínez Costas, José Manuel; González García, Francisco; Álvarez Bermúdez, María José; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (American Chemical Society, 2012)
      Chemical derivatization of nucleic stains such as ethidium bromide or DAPI with tailored, photoresponsive caging groups, allows for “on demand” spatiotemporal control of their in vivo nucleic acid binding, as well as for ...
    • Membrane-disrupting iridium(III) oligocationic organometallopeptides 

      Salvadó, Iria; Gamba, Ilaria; Montenegro García, Javier; Martínez Costas, José Manuel; Brea Floriani, José Manuel; Loza García, María Isabel; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Royal Society of Chemistry, 2016-08-19)
      A series of oligoarginine peptide derivatives containing cyclometallated iridium(III) units display remarkable cytotoxicity, comparable to that of cisplatin. In vitro studies with unilamellar vesicles support a membrane-disrupting ...
    • MitoBlue as a tool to analyze the mitochondria-lysosome communication 

      Sánchez López, Mateo Isidro; Vida, Yolanda; Pérez-Inestrosa, Ezequiel; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio; Sugiura, Ayumu; Martínez Costas, José Manuel (Springer Nature, 2020)
      MitoBlue is a fluorescent bisamidine that can be used to easily monitor the changes in mitochondrial degradation processes in different cells and cellular conditions. MitoBlue staining pattern is exceptional among mitochondrial ...
    • MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria 

      Sánchez López, Mateo Isidro; Martínez Costas, José Manuel; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (American Chemical Society, 2014)
      We report the discovery of a fluorogenic dye, N1,N3-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high ...
    • Programmed stereoselective assembly of DNA-binding helical metallopeptides 

      Gamba, Ilaria; Rama, Gustavo; Ortega-Carrasco, Elisabeth; Maréchal, Jean-Didier; Martínez Costas, José Manuel; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2014)
      A flexible and versatile synthetic approach for the construction of water-stable DNA-binding chiral peptide helicates based on the solid phase peptide synthesis (SPPS) methodology is reported
    • Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides 

      Bouzada, David; Salvadó, Iria; Barka, Ghofrane; Rama, Gustavo; Martínez Costas, José Manuel; Lorca, Romina; Somoza, Álvaro; Melle-Franco, Manuel; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2018)
      A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding ...
    • Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes 

      Sánchez López, Mateo Isidro; Vázquez Vázquez, Olalla; Martínez Costas, José Manuel; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2012)
      Bisbenzamidines are an important family of minor groove DNA-binding agents. We present a one-step synthesis of aromatic aza-bisbenzamidines that allows straightforward and versatile access to a large number of these ...
    • Tuning the Size of Nanoassembles: A Hierarchical Transfer of Information from Dendrimers to Polyion Complexes 

      Amaral, Sandra P.; Tawara, Ma’un Hasan Haroon; Fernández Villamarín, Marcos; Borrajo, Erea; Martínez Costas, José Manuel; Vidal Figueroa, Anxo; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Wiley, 2018-04-27)
      The generation of dendrimers is a powerful tool in the control of the size and biodistribution of polyion complexes (PIC). Using a combinatorial screening of six dendrimers (18–243 terminal groups) and five oppositely ...

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