Now showing items 1-8 of 8

    • Different-Length Hydrazone Activated Polymers for Plasmid DNA Condensation and Cellular Transfection 

      Priegue Caamaño, Juan Manuel; Lostalé Seijo, Irene; Crisan, Daniel; Granja Guillán, Juan Ramón; Fernández Trillo, Francisco; Montenegro García, Javier (American Chemical Society, 2018)
      The recent advances in genetic engineering demand the development of conceptually new methods to prepare and identify efficient vectors for the intracellular delivery of different nucleotide payloads ranging from short ...
    • Oligoalanine helical callipers for cell penetration 

      Pazo Pascual, Marta; Juanes Carrasco, Marisa; Lostalé Seijo, Irene; Montenegro García, Javier (Royal Society of Chemistry, 2018-05-23)
      Even for short peptides that are enriched in basic amino acids, the large chemical space that can be spanned by combinations of natural amino acids hinders the rational design of cell penetrating peptides. We here report ...
    • Peptide/Cas9 nanostructures for ribonucleoprotein cell membrane transport and gene edition 

      Lostalé Seijo, Irene; Louzao Pernas, Iria; Juanes Carrasco, María Luisa; Montenegro García, Javier (Royal Society of Chemistry, 2017)
      The discovery of RNA guided endonucleases has emerged as one of the most important tools for gene edition and biotechnology. The selectivity and simplicity of the CRISPR/Cas9 strategy allows the straightforward targeting ...
    • Supramolecular caging for cytosolic delivery of anionic probes 

      Fernández Caro, Héctor; Lostalé Seijo, Irene; Martínez Calvo, Miguel; Mosquera Mosquera, Jesús; Mascareñas Cid, José Luis; Montenegro García, Javier (Royal Society of Chemistry, 2019)
      The cytosolic delivery of hydrophilic, anionic molecular probes and therapeutics is a major challenge in chemical biology and medicine. Herein, we describe the design and synthesis of peptide–cage hybrids that allow an ...
    • Supramolecular Recognition and Selective Protein Uptake by Peptide Hybrids 

      Juanes Carrasco, Marisa; Lostalé Seijo, Irene; Granja Guillán, Juan Ramón; Montenegro García, Javier (Wiley, 2018-04-27)
      The intracellular transport of exogenous proteins has emerged as one of the most promising methodologies for biotechnology and chemical biology. Current protein delivery is mainly approached by liposome encapsulation, ...
    • Synthetic materials at the forefront of gene delivery 

      Lostalé Seijo, Irene; Montenegro García, Javier (Springer Nature, 2018-09-21)
      The delivery of nucleic acids with transient activity for genetic engineering is a promising methodology with potential applications in the treatment of diseases ranging from cancer and infectious diseases to heritable ...
    • Tuning the properties of penetrating peptides by oxime conjugation 

      Pazo Pascual, Marta; Fernández Caro, Héctor; Priegue Caamaño, Juan Manuel; Lostalé Seijo, Irene; Montenegro García, Javier (Georg Thieme Verlag, 2017-01-25)
      We here describe the application of oxime bond formation between a peptide scaffold and different aldehydes to modify the transporting capabilities of penetrating peptides. We show that bonds such as oximes offer a great ...
    • Where in the cell is our cargo? Current methods to study intracellular cytosolic localization 

      Méndez Ardoy, Alejandro; Lostalé Seijo, Irene; Montenegro García, Javier (2018-09-03)
      The internalization and delivery of active substances into cells is a field of growing interest for chemical biology and therapeutics. As we move from small‐molecule based drugs towards bigger cargos, such as antibodies, ...





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