Now showing items 1-10 of 10

    • Antibacterial activity and molecular docking studies of a selected series of Hydroxy-3-arylcoumarins 

      Pisano, Maria Barbara; Kumar, Amit; Medda, Rosaria Medda; Gatto, Gianluca; Pal, Rajesh; Fais, Antonella; Era, Benedetta; Cosentino, Sofia; Uriarte Villares, Eugenio; Santana Penín, María Lourdes; Pintus, Francesca; Matos, Maria João Correia Pinto Carvalho de (MDPI, 2019)
      Antibiotic resistance is one of the main public health concerns of this century. This resistance is also associated with oxidative stress, which could contribute to the selection of resistant bacterial strains. Bearing ...
    • Detection of drug-drug interactions by modeling interaction profile fingerprints 

      Vilar Varela, Santiago; Uriarte Villares, Eugenio; Santana Penín, María Lourdes; Tatonetti, Nicholas P.; Friedman, Carol (PLOS, 2013)
      Drug-drug interactions (DDIs) constitute an important problem in postmarketing pharmacovigilance and in the development of new drugs. The effectiveness or toxicity of a medication could be affected by the co-administration ...
    • Methyl derivatives of tetracyclic psoralen analogues: antiproliferative activity and interaction with DNA 

      Dalla Via, Lisa; Uriarte Villares, Eugenio; Santana Penín, María Lourdes; Marciani Magno, Sebastiano; Gia, Ornella (Arkat USA Inc, 2004)
      A number of new tetracyclic psoralen derivatives were studied. The fourth ring is constituted by cyclopentane (4, 7 and 9), cyclohexane (11, 15 and 18) or benzene (12, 16 and 20) fused to either 4',5' or 3,4 photoreactive ...
    • Potent and selective MAO-B inhibitory activity: Amino- versus nitro-3-arylcoumarin derivatives 

      Matos, Maria João Correia Pinto Carvalho de; Rodríguez Enríquez, Fernanda; Vilar, Santiago; Santana Penín, María Lourdes; Uriarte Villares, Eugenio; Hripcsak, George; Estrada, Martín; Rodríguez Franco, María Isabel; Viña Castelao, María Dolores (Elsevier, 2015)
      In this study we synthesized and evaluated a new series of amino and nitro 3-arylcoumarins as hMAO-A and hMAO-B inhibitors. Compounds 2, 3, 5 and 6 presented a better activity and selectivity profile against the hMAO-B ...
    • Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins 

      Matos, Maria João Correia Pinto Carvalho de; Pérez Cruz, Fernanda; Vázquez Rodríguez, Saleta; Uriarte Villares, Eugenio; Santana Penín, María Lourdes; Borges, Fernanda; Olea Azar, Claudio (Elsevier, 2013)
      In the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1–9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical ...
    • Study of coumarin-resveratrol hybrids as potent antioxidant compounds 

      Matos, Maria João Correia Pinto Carvalho de; Mura, Francisco; Vázquez Rodríguez, Saleta; Borges, Fernanda; Santana Penín, María Lourdes; Uriarte Villares, Eugenio; Olea Azar, Claudio (MDPI, 2015)
      In the present work we synthesized a selected series of hydroxylated 3-phenylcoumarins 5–8, with the aim of evaluating in detail their antioxidant properties. From an in depth study of the antioxidant capacity data ...
    • Synthesis and structure-activity relationships of novel amino/nitro substituted 3-arylcoumarins as antibacterial agents 

      Matos, Maria João Correia Pinto Carvalho de; Vázquez Rodríguez, Saleta; Santana Penín, María Lourdes; Uriarte Villares, Eugenio; Fuentes Edfuf, Cristina; Santos Rodríguez, María Ysabel; Muñoz Crego, María Ángeles (MDPI, 2013)
      A new series of amino/nitro-substituted 3-arylcoumarins were synthesized and their antibacterial activity against clinical isolates of Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) was evaluated. ...
    • Synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-Halo-3-phenylcoumarins 

      Quezada González, Elías Neftalí; Delogu, Giovanna Lucia; Picciau, Carmen; Santana Penín, María Lourdes; Podda, Gianni; Borges, Fernanda; García Morales, Verónica; Viña Castelao, María Dolores; Orallo Cambeiro, Francisco (MDPI, 2010)
      A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant ...
    • Trending Topics on Coumarin and Its Derivatives in 2020 

      Carneiro Viqueira, Aitor; Matos, Maria João Correia Pinto Carvalho de; Uriarte Villares, Eugenio; Santana Penín, María Lourdes (MDPI, 2021)
      Coumarins are naturally occurring molecules with a versatile range of activities. Their structural and physicochemical characteristics make them a privileged scaffold in medicinal chemistry and chemical biology. Many ...
    • Tyrosinase inhibitor activity of coumarin-resveratrol hybrids 

      Fais, Antonella; Corda, Marcella; Era, Benedetta; Fadda, M. Benedetta; Matos, Maria João Correia Pinto Carvalho de; Quezada González, Elías Neftalí; Santana Penín, María Lourdes; Picciau, Carmen; Podda, Gianni; Delogu, Giovanna Lucia (MDPI, 2009)
      In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 ...





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