Now showing items 1-3 of 3

    • Development of fluorescent probes that target serotonin 5-HT2B receptors 

      Azuaje Guerrero, Jhonny Alberto; López, Paula; Iglesias Fernández, Alba; Fuente, Rocío de la; Pérez Rubio, José M.; García Peña, Diego; Stępniewski, Tomasz Maciej; García Mera, Xerardo Xusto; Brea Floriani, José Manuel; Selent, Jana; Pérez Meirás, María Dolores; Castro Pérez, María de los Ángeles; Loza García, María Isabel; Sotelo Pérez, Eddy (Nature Publishing Group, 2017)
      Some 5-HT2B fluorescent probes were obtained by tagging 1-(2,5-dimethoxy-4-iodophenyl)-propan2-amine (DOI) with a subset of fluorescent amines. Some of the resulting fluorescent ligands showed excellent affinity and ...
    • High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides 

      Gamba, Ilaria; Salvadó, Iria; Brissos, Rosa F.; Gamez, Patrick; Brea Floriani, José Manuel; Loza García, María Isabel; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2016)
      We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding ...
    • Membrane-disrupting iridium(III) oligocationic organometallopeptides 

      Salvadó, Iria; Gamba, Ilaria; Montenegro García, Javier; Martínez Costas, José Manuel; Brea Floriani, José Manuel; Loza García, María Isabel; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Royal Society of Chemistry, 2016-08-19)
      A series of oligoarginine peptide derivatives containing cyclometallated iridium(III) units display remarkable cytotoxicity, comparable to that of cisplatin. In vitro studies with unilamellar vesicles support a membrane-disrupting ...





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