Now showing items 1-5 of 5

    • 8‐Aminomethyl‐7‐hydroxy‐4‐methylcoumarins as Multitarget Leads for Alzheimer's Disease 

      Domínguez, José L.; Fernández-Nieto, Fernando; Brea Floriani, José Manuel; CATTO, Marco; Paleo, M. Rita; Porto, Silvia; Sardina, F. Javier; Castro, Marian; PISANI, Leonardo; Carotti, Angelo; Soto-Otero, Ramón; Méndez-Álvarez, Estefanía; Villaverde Cameron-Walker, María del Carmen; Sussman, Fredy Salomon (Wiley, 2016-07-22)
      This work is part of our ongoing research in the discovery of multitarget therapeutic agents for Alzheimer's disease (AD). A literature screening, based on our recently proposed pharmacophore, led to the identification of ...
    • Computer-Aided Structure-Based Design of Multitarget Leads for Alzheimer’s Disease 

      Domínguez, José L.; Fernández-Nieto, Fernando; Castro, Marian; CATTO, Marco; Paleo, M. Rita; Porto, Silvia; Sardina, F. Javier; Brea Floriani, José Manuel; Carotti, Angelo; Villaverde Cameron-Walker, María del Carmen; Sussman, Fredy Salomon (American Chemical Society, 2015)
      Alzheimer’s disease is a neurodegenerative pathology with unmet clinical needs. A highly desirable approach to this syndrome would be to find a single lead that could bind to some or all of the selected biomolecules that ...
    • Enantioselective Annulation Reactions of Bisenolates Prepared Through Dearomatization Reactions of Aromatic and Heteroaromatic Diesters 

      Pérez-Vázquez, Jaime; Veiga, Alberte X.; Prado, Gustavo; Sardina, F. Javier; Paleo, M. Rita (Wiley, 2012)
      A one‐pot, enantioselective strategy for the dearomatization–annulation of aromatic diesters to give a range of highly functionalized polycyclic molecules with excellent enantioselectivity is presented. This methodology ...
    • A One-Step, Versatile Synthesis of Dibenzo [n.2.2] Macrobicyclic Compounds via a Conformation-Directed Macrocyclization Reaction 

      Lobato, Rubén; Veiga, Alberte X.; Pérez-Vázquez, Jaime; Fernández-Nieto, Fernando; Paleo, M. Rita; Sardina, F. Javier (American Chemical Society, 2013)
      A series of dibenzo [n.2.2] bicyclic compounds (n = 2–20) were prepared in one step and good yields starting from dimethyl anthracene-9,10-dicarboxylate. Reduction of the aromatic diester using lithium/naphthalene led to ...
    • A Two-Step, Stereoselective Synthesis of Nine- and Ten-Membered Carbocycles from Phthalates 

      Prado, Gustavo; Veiga, Alberte X.; Fernández-Nieto, Fernando; Paleo, M. Rita; Sardina, F. Javier (American Chemical Society, 2015)
      A two-step, stereoselective procedure for the synthesis of nine- and ten-membered carbocycles from readily available phthalates is described. A variety of dialkyl phthalates have been transformed into [6,n]-fused bicyclo ...





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