Now showing items 1-8 of 8

    • A bio-inspired hypoxia sensor using HIF1a-oxygen-dependent degradation domain 

      Iglesias, Pablo; Penas Tallón, Cristina; Barral Cagiao, Laura; Pazos Chantrero, Elena; Costoya Puente, José Antonio (Nature Publishing Group, 2019)
      Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. ...
    • A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC 

      Calo Lapido, Renata; Penas Tallón, Cristina; Jiménez Balsa, Adrián; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2019)
      We describe the first chemical synthesis of a functional mutant of the DNA binding domain of the oncoprotein MYC, using two alternative strategies which involve either one or two Native Chemical Ligations (NCLs). Both ...
    • Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(III) and Eu(III) ions for specific sensing of a viral RNA 

      Penas Tallón, Cristina; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (Royal Society of Chemistry, 2016-01-10)
      Rational modification of a natural RNA-binding peptide with a lanthanide EDTA chelator, and a phenanthroline ligand yields a highly selective luminescent sensor. The sensing mechanism relies on the RNA-triggered folding ...
    • A Folding-Based Approach for the Luminescent Detection of a Short RNA Hairpin 

      Penas Tallón, Cristina; Pazos Chantrero, Elena; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (American Chemical Society, 2013)
      We report the rational design of a 20-mer basic peptide, derived from the transcriptional antitermination protein N of bacteriophage P22, equipped with a luminescent DOTA[Tb3+] macrocyclic complex and a sensitizing tryptophan ...
    • Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos 

      Penas Tallón, Cristina; Sánchez López, Mateo Isidro; Guerra Varela, Jorge; Sánchez Piñón, Laura; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Wiley, 2016)
      We synthesized octa‐arginine conjugates of DNA‐binding agents (bisbenzamidine, acridine and Thiazole Orange) and demonstrated that their DNA binding and cell internalization can be inhibited by appending a (negatively ...
    • Metal-catalyzed uncaging of DNA-binding agents in living cells 

      Sánchez López, Mateo Isidro; Penas Tallón, Cristina; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2014)
      Attachment of alloc protecting groups to the amidine units of fluorogenic DNA-binding bisbenzamidines or to the amino groups of ethidium bromide leads to a significant reduction of their DNA affinity. More importantly, the ...
    • Peptide–DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun 

      Pazos Chantrero, Elena; Portela Pallares, Cecilia; Penas Tallón, Cristina; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2015)
      We describe a ds-oligonucleotide–peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of ...
    • Surface-enhanced raman scattering surface selection rules for the proteomic liquid biopsy in real samples: Efficient detection of the oncoprotein c-MYC 

      Pazos Chantrero, Elena; García-Algar, Manuel; Penas Tallón, Cristina; Nazarenus, Moritz; Torruella, Arnau; Pazos-Pérez, Nicolás; Guerrini, Luca; Vázquez Sentís, Marco Eugenio; García-Rico, Eduardo; Mascareñas Cid, José Luis; Álvarez-Puebla, Ramón A. (American Chemical Society, 2016-10-12)
      Blood-based biomarkers (liquid biopsy) offer extremely valuable tools for the noninvasive diagnosis and monitoring of tumors. The protein c-MYC, a transcription factor that has been shown to be deregulated in up to 70% of ...





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