Now showing items 1-2 of 2

    • Benzoic acid-derived nitrones: a new class of potential acetylcholinesterase inhibitors and neuroprotective agents 

      Oliveira, Catarina; Bagetta, Donatella; Cagide, Fernando; Teixeira, José; Amorim, Ricardo; Silva, Tiago; Garrido, Jorge; Remião, Fernando; Uriarte Villares, Eugenio; Oliveira, Paulo J.; Alcaro, Stefano; Ortuso, Francesco; Borges, Fernanda (Elsevier, 2019)
      The discovery of new chemical entities endowed with potent and selective acetylcholinesterase (AChE) and/or butyrylcholinesterase (BChE) inhibitory activity is still a relevant subject for Alzheimer's disease therapy. ...
    • Hydroxybenzoic acid derivatives as dual-target ligands: mitochondriotropic antioxidants and cholinesterase inhibitors 

      Oliveira, Catarina; Cagide, Fernando; Teixeira, José; Amorim, Ricardo; Sequeira, Lisa; Mesiti, Francesco; Silva, Tiago; Garrido, Jorge; Remião, Fernando; Vilar Varela, Santiago; Uriarte Villares, Eugenio; Oliveira, Paulo J.; Borges, Fernanda (Frontiers Media, 2018)
      Alzheimer's disease (AD) is a multifactorial age-related disease associated with oxidative stress (OS) and impaired cholinergic transmission. Accordingly, targeting mitochondrial OS and restoring cholinergic transmission ...





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