Now showing items 1-5 of 5

    • Activity of the β-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii 

      Vázquez Ucha, Juan Carlos; Maneiro Rey, María; Martínez Guitián, Marta; Buynak, John; Bethel, Christopher R.; Bonomo, Roberto A.; Bou, Germán; Poza, Margarita; González Bello, Concepción; Beceiro Casas, Alejandro (American Society for Microbiology, 2017)
      The number of infections caused by Gram-negative pathogens carrying carbapenemases is increasing, and the group of carbapenem-hydrolyzing class D β-lactamases (CHDLs) is especially problematic. Several clinically important ...
    • Chemo- and Regioselective Lysine Modification on Native Proteins 

      Matos, Maria João Correia Pinto Carvalho de; Oliveira, Bruno L.; Martínez Saéz, Nuria; Guerreiro, Ana; Cal, Pedro M.S.D.; Bertoldo, Jean Borges; Maneiro Rey, María; Perkins, Elizabeth; Howard, Julie A.; Deery, Michael J.; Chalker, Justin M.; Corzana, Francisco; Jiménez Osés, Gonzalo; Bernardes, Gonçalo J.L. (American Chemical Society, 2018)
      Site-selective chemical conjugation of synthetic molecules to proteins expands their functional and therapeutic capacity. Current protein modification methods, based on synthetic and biochemical technologies, can achieve ...
    • Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme 

      Maneiro Rey, María; Lence Quintana, Emilio José; Sanz Gaitero, Marta; Otero Casas, José Manuel; Raaij, Mark J. van; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (Royal Society of Chemistry, 2019)
      Targeted irreversible inhibitors bearing electrophiles that become activated towards covalent bond formation upon binding to a specific protein/enzyme is an emerging area in drug discovery. Targeting lysine residues is ...
    • Insights into substrate binding and catalysis in bacterial type I dehydroquinase 

      Maneiro Rey, María; Peón López, Antonio; Lence Quintana, Emilio José; Otero Casas, José Manuel; Raaij, Mark J. van; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (Portland Press, 2014-09-15)
      Structural, biochemical and computational studies to study substrate binding and the role of the conserved residues of the DHQ1 (type I dehydroquinase) enzyme active site are reported in the present paper. The crystal ...
    • Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme 

      Prado, Verónica; Lence Quintana, Emilio José; Maneiro Rey, María; Vázquez Ucha, Juan Carlos; Beceiro Casas, Alejandro; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (American Chemical Society, 2016)
      The large conformational changes observed by Molecular Dynamics simulation studies on the product release in the LID and shikimic acid binding (SB) domains of the shikimate kinase (SK) enzyme have been exploited in the ...

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