Now showing items 1-20 of 387

    • 1,7-Naphthodiyne: a new platform for the synthesis of novel, sterically congested PAHs 

      Pozo Míguez, Iago; Cobas Martínez, Agustín; Peña Gil, Diego; Guitián Rivera, Enrique; Pérez Meirás, María Dolores (Royal Society of Chemistry, 2016-03-17)
      The synthesis of an efficient precursor of the novel 1,7-naphthodiyne synthon is reported. Preliminary experiments demonstrate the usefulness of this platform for the synthesis of sterically congested polyarenes, such as ...
    • 1D alignment of proteins and other nanoparticles by using reversible covalent bonds on cyclic peptide nanotubes 

      Priegue Caamaño, Juan Manuel; Louzao Pernas, Iria; Gallego Gómez, Iván; Montenegro García, Javier; Granja Guillán, Juan Ramón (Royal Society of Chemistry, 2021)
      Self-assembling cyclic peptide nanotubes are supramolecular structures whose diameter and external surface properties are precisely controlled. In this communication we describe a general strategy to align different molecules ...
    • 1D to 2D Self Assembly of Cyclic Peptides 

      Insua López, Ignacio; Montenegro García, Javier (American Chemical Society, 2020)
      Despite recent developments in two-dimensional self-assembly, most supramolecular 2D materials are assembled by tedious methodologies, with complex surface chemistry and small sizes. We here report d/l-alternating cyclic ...
    • (1RS,4RS,5RS)-Methyl 2-(3,5-di­nitro­benzo­yl)-2-oxa-3-aza­bi­cyclo­[3.3.0]oct-7-ene-4-carboxyl­ate 

      Sousa, Carlos A.D.; Rodríguez Borges, José E.; Vale, M. Luísa C.; García Mera, Xerardo Xusto (International Union of Crystallography, 2009)
      In organic synthesis, the usual techniques as NMR, mass or infra-red spectrometry and elemental analysis are often not enough for the unequivocally determination of a structure of a compound. When it is possible to ...
    • [2+1] Cycloaddition of Catalytic Ruthenium Vinyl Carbenes: A Stereoselective Controlled Access to (Z)- and (E)-Vinyl Epoxypyrrolidines 

      Padín Santos, Damián; Cambeiro Cambeiro, Fermín; Fañanás Mastral, Martín; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (American Chemical Society, 2016)
      Aza-alkynals undergo a cyclization reaction with diazo compounds in the presence of catalytic amounts of Cp*RuCl(cod) to afford vinyl epoxypyrrolidines, valuable building blocks for the synthesis of biologically active ...
    • 3-O-Benzyl-6-O-benzoyl-1,2-Oisopropilidene-5-C-nitromethyl-a-Dglucofuranose 

      Pampín Casal, María Begoña; Valencia Matarranz, Laura; Estévez Cabanas, Juan Carlos; Estévez Cabanas, Ramón José (International Union of Crystallography, 2008)
      The title compound, C24H27NO9, is one of the epimers of the Henry reaction of 3-O-benzyl-6-O-benzoyl-2-O-isopropyl­idene-a-D-glucofuran-5-one with nitro­methane. The conformation of the five membered rings is as expected ...
    • A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition 

      Gallego Gómez, Iván; Ramos Soriano, Javier; Méndez Ardoy, Alejandro; Cabrera González, Justo; Lostalé Seijo, Irene; Illescas, Beatriz; Reina Martín, José Juan; Martín León, Nazario; Montenegro García, Javier (Wiley, 2022)
      Multivalent ligand presentation is a powerful strategy for the development of specific binders and inhibitors. Peptide/[60]fullerene hybrids have now been synthesized that exploit the complete substitution of the fullerene ...
    • (4 + 2) Cycloadditions via Pd C(sp3 )–H activation 

      Vidal Pereira, Xandro; Font Molíns, Marc; Cendón Mariño, Borja; Mascareñas Cid, José Luis; Gulías Costa, Moisés (Elsevier, 2021)
      The functionalization of aliphatic C (sp3)-H bonds using Pd catalysis has emerged as a powerful, step economical methodology for the construction of C–C and C–X bonds. Despite the progress in this field, examples of formal ...
    • [4+2] and [4+3] catalytic cycloadditions of allenes 

      López García, Fernando; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2014)
      This feature review describes the development of catalytic [4+2] and [4+3] cycloadditions of allenes, as efficient and practical methodologies for assembling six and seven-membered cyclic systems. The different methodologies ...
    • 8‐Aminomethyl‐7‐hydroxy‐4‐methylcoumarins as Multitarget Leads for Alzheimer's Disease 

      Domínguez, José L.; Fernández-Nieto, Fernando; Brea Floriani, José Manuel; CATTO, Marco; Paleo, M. Rita; Porto, Silvia; Sardina, F. Javier; Castro, Marian; PISANI, Leonardo; Carotti, Angelo; Soto-Otero, Ramón; Méndez-Álvarez, Estefanía; Villaverde Cameron-Walker, María del Carmen; Sussman, Fredy Salomon (Wiley, 2016-07-22)
      This work is part of our ongoing research in the discovery of multitarget therapeutic agents for Alzheimer's disease (AD). A literature screening, based on our recently proposed pharmacophore, led to the identification of ...
    • Activity of the β-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii 

      Vázquez Ucha, Juan Carlos; Maneiro Rey, María; Martínez Guitián, Marta; Buynak, John; Bethel, Christopher R.; Bonomo, Roberto A.; Bou, Germán; Poza, Margarita; González Bello, Concepción; Beceiro Casas, Alejandro (American Society for Microbiology, 2017)
      The number of infections caused by Gram-negative pathogens carrying carbapenemases is increasing, and the group of carbapenem-hydrolyzing class D β-lactamases (CHDLs) is especially problematic. Several clinically important ...
    • Adenosine Receptor Ligands: Coumarin–Chalcone Hybrids as Modulating Agents on the Activity of hARs 

      Vázquez Rodríguez, Saleta; Vilar, Santiago; Kachler, Sonja; Klotz, Karl-Norbert; Uriarte Villares, Eugenio; Borges, Fernanda; Matos, Maria João Correia Pinto Carvalho de (MDPI, 2020)
      Adenosine receptors (ARs) play an important role in neurological and psychiatric disorders such as Alzheimer’s disease, Parkinson’s disease, epilepsy and schizophrenia. The different subtypes of ARs and the knowledge on ...
    • Advances in lanthanide‐based luminescent peptide probes for monitoring the activity of kinase and phosphatase 

      Pazos Chantrero, Elena; Vázquez Sentís, Marco Eugenio (Wiley, 2014)
      Signaling pathways based on protein phosphorylation and dephosphorylation play critical roles in the orchestration of complex biochemical events and form the core of most signaling pathways in cells (i.e. cell cycle ...
    • Aggregation versus inclusion complexes to solubilize drugs with cyclodextrins. A case study using sulphobutylether-β-cyclodextrins and remdesivir 

      Piñeiro Guillén, Ángel; García Fandiño, Rebeca; PIPKIN, JAMES; Antle, Vince (Elsevier, 2021)
      The formation of small hybrid aggregates between excipient and drug molecules is one of the mechanisms that contributes to the solubilization of active principles in pharmaceutical formulations. The characterization of the ...
    • Allenes and Derivatives in Gold(I)- and Platinum(II)-Catalyzed Formal Cycloadditions 

      Mascareñas Cid, José Luis; Varela Sandá, Iván; López García, Fernando (American Chemical Society, 2019)
      Conspectus Cycloaddition reactions, by involving the formation of at least two bonds and one cycle in a single operation, represent one of the more practical ways to assemble carbo- and heterocyclic structures from ...
    • Amide-Directed Formation of Five-Coordinate Osmium Alkylidenes from Alkynes 

      Casanova González, Noelia; Esteruelas, Miguel A.; Larramona, Carmen; Mascareñas Cid, José Luis; Gulías Costa, Moisés (American Chemical Society, 2015-12-31)
      The amide-directed synthesis of five-coordinate osmium alkylidene derivatives from alkynes is reported. These types of complexes, which have been elusive until now because of the tendency of osmium to give hydride alkylidyne ...
    • An aquaporin 4 antisense oligonucleotide loaded, brain targeted nanoparticulate system design 

      Kozlu, S.; Caban, Secil; Yerlikaya, F.; Fernández Megía, Eduardo; Novoa Carballal, Ramón; Riguera Vega, Ricardo; Yemisci, Muge; Gursoy-Ozdemir, Yasemin; Dalkara, Turgay; Couvreur, Partick; Capan, Yilmaz (Avoxa - Mediengruppe Deutscher Apotheker GmbH, 2014-05)
      Aquaporins (AQPs), members of the water-channel protein family, are highly expressed in brain tissue especially in astrocytic end-feet. They are important players for water hemostasis during development of cytotoxic as ...
    • An automated method to find reaction mechanisms and solve the kinetics in organometallic catalysis 

      Varela Carrete, Jesús Ángel; Vázquez Rodríguez, Saulo Angel; Martínez Núñez, Emilio (Royal Society of Chemistry, 2017)
      A novel computational method is proposed in this work for use in discovering reaction mechanisms and solving the kinetics of transition metal-catalyzed reactions. The method does not rely on either chemical intuition or ...
    • An on-surface Diels–Alder reaction 

      Castro-Esteban, Jesús; Albrecht, Florian; Fatayer, Shadi; Pérez Meirás, María Dolores; Gross, Leo; Peña Gil, Diego (Wiley, 2021)
      The Diels–Alder reaction is one of the most popular reactions in organic chemistry. However, its use in the field of on-surface synthesis is hampered by the spatial restrictions of this cycloaddition reaction. Herein we ...
    • Anion recognition and induced self-assembly of an alpha,gamma-cyclic peptide to form spherical clusters 

      Rodríguez-Vázquez, Nuria; Amorín López, Manuel; Granja Guillán, Juan Ramón; Alfonso, Ignacio (Wiley, 2016-03-21)
      A cyclic octapeptide composed of hydroxy-functionalized γ-amino acids folds in a "V-shaped" conformation that allows the selective recognition of anions such as chloride, nitrate, and carbonate. The process involves the ...





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