Now showing items 202-221 of 387

    • N-Doped Cationic PAHs by Rh(III)-Catalyzed Double C–H Activation and Annulation of 2-Arylbenzimidazoles with Alkynes 

      Villar Carabel, José Manuel; Suárez Rivero, Jaime; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (American Chemical Society, 2017)
      A novel class of N-doped cationic PAHs (Polycyclic Aromatic Hydrocarbons) bearing the benzo[c,d]fluoranthene scaffold has been synthesized by the Rh(III)-catalyzed double oxidative annulation of 2-arylbenzimidazoles with ...
    • Natural Products for Neurodegeneration: Regulating Neurotrophic Signals 

      Uddin, Sahab; Al Mamun, Abdullah; Rahman, Motiar; Jeandet, Philippe; Alexiou, Athanasios; Behl, Tapan; Sarwar, Shahid; Sobarzo Sánchez, Eduardo Marcelo; Ashraf, Ghulam; Sayed, Amany; Albadrani, Ghadeer Mohsen; Peluso, Ilaria; Abdel-Daim, Mohamed (Hindawi, 2021)
      Neurodegenerative disorders (NDs) are heterogeneous groups of ailments typically characterized by progressive damage of the nervous system. Several drugs are used to treat NDs but they have only symptomatic benefits with ...
    • New 2-Oxoindolin Phosphonates as Novel Agents to Treat Cancer: A Green Synthesis and Molecular Modeling 

      Tiwar, Shailee V.; Sharif, Nawaz S.; Gajare, Rekha I.; Seijas Vázquez, Julio Antonio; Sangshetti, Jaiprakash N.; Damale, Manoj D.; Nikalje, Anna Pratima G. (MDPI, 2018)
      The work reports the facile synthesis of novel α-aminophosphonate derivatives coupled with indole-2,3-dione moieties, namely the diethyl(substituted phenyl/heteroaryl)(2-(2-oxoindolin-3-ylidene)hydrazinyl)methylphosphonates ...
    • A New Approach to the Synthesis of Benzo[b]naphtho[2,3-b]furan-6,11-diones and 2-Benzyl-3-hydroxynaphthalene-1,4-diones 

      Barcia Barcia, José Carlos; Cruces, Jacobo; Salas, Cristian O.; Estévez Cabanas, Juan Carlos; Cuéllar, Mauricio A.; Tapia, Ricardo A.; Estévez Cabanas, Ramón José (Georg Thieme Verlag, 2017)
      Here we describe modified syntheses of o-acetylbenzoic acids and o-acetylphenylacetic acids by Heck palladium-catalysed arylation of n-butyl vinyl ether with o-iodobenzoic acids or with o-iodophenylacetic acids, respectively. ...
    • New Morphiceptin Peptidomimetic Incorporating (1S,2R,3S,4S,5R)-2-Amino-3,4,5-trihydroxycyclopen-tane-1-carboxylic acid: Synthesis and Structural Study 

      González Soengas, Raquel María; Lorca Carvajal, Marcos Antonio; Pampín Casal, María Begoña; Sánchez Pedregal, Víctor Manuel; Estévez Cabanas, Ramón José; Estévez Cabanas, Juan Carlos (MDPI, 2020)
      We present the synthesis and structural study of a new peptidomimetic of morphiceptin, which can formally be considered as the result of the replacement of the central proline residue of this natural analgesic drug with a ...
    • A New Pathway for Protein Haptenation by β‐Lactams 

      Pérez Ruiz, Raúl; Lence Quintana, Emilio José; Andreu, Inmaculada; Limones Herrero, Daniel; González Bello, Concepción; Miranda, Miguel A.; Jiménez, Consuelo M. (Wiley, 2017-08-09)
      The covalent binding of β‐lactams to proteins upon photochemical activation has been demonstrated by using an integrated approach that combines photochemical, proteomic and computational studies, selecting human serum ...
    • A new potential nano-oncological therapy based on polyamino acid nanocapsules 

      Gonzalo, Teresa; Lollo, Giovanna; García-Fuentes, Marcos; Torres, Dolores; Correa, Juan; Riguera Vega, Ricardo; Fernández Megía, Eduardo; Calvo, Pilar; Avilés, Pablo; Guillén, Maria José; Alonso Fernández, María José (Elsevier, 2013-07)
      A critical objective in cancer therapy is to reduce the systemic toxicity through the modification of the biodistribution of anticancer drugs. Herein, we disclose a new biodegradable nanocarrier, polyglutamic acid (PGA) ...
    • New self-assembling peptide nanotubes of large diameter using δ-amino acids 

      Lamas Pérez, Alejandro; Guerra Fandiño, Arcadio José; Amorín López, Manuel; Granja Guillán, Juan Ramón (Royal Society of Chemistry, 2018)
      Here we show that 4-aminocyclohexanecarboxylic acid is a rigid stretcher building block for the preparation of cyclic peptides that self-assemble to form peptide nanotubes with large diameter and hydrophobic pores. The ...
    • Nickel-Catalyzed Intramolecular [3 + 2 + 2] Cycloadditions of Alkylidenecyclopropanes. A Straightforward Entry to Fused 6,7,5- Tricyclic Systems 

      Saya Codesal, Lucía; Fernández, Israel; Mascareñas Cid, José Luis; López García, Fernando (American Chemical Society, 2014-09-18)
      A highly diastereo- and chemoselective intramolecular nickel-catalyzed cycloaddition of alkene- and alkyne-tethered alkynylidenecyclopropanes is reported. The method constitutes the first fully intramolecular [3 + 2 + 2] ...
    • Nickel-promoted recognition of long DNA sites by designed peptide derivatives 

      Rodríguez Villar, Jéssica; Mosquera Mosquera, Jesús; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (WILEY-VCH Verlag GmbH, 2016-08-03)
      We describe the synthesis of designed peptidic modules that self-assemble in specific DNA sequences of 12 base pairs in the presence of NiII salts. The modules consist of modified fragments of transcription factors that ...
    • Nonplanar Tub-shaped Benzocyclooctatetraenes via Halogen-Radical Ring Opening of Dihydrobiphenylenes 

      Bello García, Jesús; Padín Santos, Damián; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (American Chemical Society, 2021)
      A novel tandem Ru-catalyzed [2 + 2 +2] cycloaddition of arylenynes to dihydrobiphenylenes followed by halogen-radical ring opening has been developed for the construction of tub-shaped halogenated benzocyclooctatetraenes ...
    • Not so rigid capsids based on cyclodextrin complexes: keys to design 

      Suárez Lestón, Fabián; Fernández Garrido, Pablo; Piñeiro Guillén, Ángel; García Fandiño, Rebeca (Elsevier, 2022)
      Membranes based on cyclodextrin complexes can be used as functional nanocarrier envelopers by chemical modifications of the cyclodextrin hydroxyl groups or by encapsulating different ligands in their cavities. Experiments: ...
    • Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine 

      Coco, Laura del; Majellaro, María; Boccarelli, Angelina; Cellamare, Saverio; Altomare, Cosimo Damiano; Fanizzi, Francesco Paolo (MDPI, 2020)
      A 1H-NMR-based metabolomic study was performed on MCF-7 cell lines treated with a novel nicotinamide derivative (DT-8) in comparison with two drugs characterized by a well-established mechanism of action, namely the ...
    • Novel Supramolecular Nanoparticles Derived From Cucurbit[7]uril and Zwitterionic Surfactants 

      Fernández Rosas, Josefa; Pessêgo, Márcia Isabel Duarte; Acuña, Angel; Vazquez-Vazquez, Carlos; Montenegro García, Javier; Parajo, Mercedes; Rodriguez-Dafonte, Pedro; Nome, Faruk; García Río, Luis (American Chemistry Society, 2018-02-12)
      Binding constants, Log K ≈ 6.6 M-1, and NMR characterization of the complexes formed by sulfobetaines and cucurbit[7]uril (CB7) support the electrostatic interaction as major driving force. This very strong binding motif ...
    • Novel synthesis of platinum complexes and their intracellular delivery to tumor cells by means of magnetic nanoparticles 

      Quarta, Alessandra; Amorín López, Manuel; Aldegunde Rodríguez, María José; Blasi, Laura; Ragusa, Andrea; Nitti, Simone; Pugliese, Giammarino; Granja Guillán, Juan Ramón; Pellegrino, Teresa (Royal Society of Chemistry, 2019)
      Platinum-based drugs are popular in clinics as chemotherapeutic agents to treat solid tumors. However, severe side effects such as nephro- and neurotoxicity impose strict dosage limitations that can lead to the development ...
    • Nucleophilic Addition of Amines to Ruthenium Carbenes: ortho‐(Alkynyloxy)benzylamine Cyclizations towards 1,3‐Benzoxazines 

      González Rodríguez, Carlos; Suárez Álvarez, José Ramón; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (Wiley, 2015)
      A new ruthenium-catalyzed cyclization of ortho-(alkynyloxy)benzylamines to dihydro-1,3-benzoxazines is reported. The cyclization is thought to take place via the vinyl ruthenium carbene intermediates that are easily formed ...
    • Oligoalanine helical callipers for cell penetration 

      Pazo Pascual, Marta; Juanes Carrasco, Marisa; Lostalé Seijo, Irene; Montenegro García, Javier (Royal Society of Chemistry, 2018-05-23)
      Even for short peptides that are enriched in basic amino acids, the large chemical space that can be spanned by combinations of natural amino acids hinders the rational design of cell penetrating peptides. We here report ...
    • On-surface synthesis and collective spin excitations of a triangulene-based nanostar 

      Hieulle, Jeremy; Castro Fernández, Silvia; Friedrich, Niklas; Vegliante, Alessio; Romero-Lara, Francisco; Sanz, Sofía; Rey Vieites, Dulce María; Corso, Martina; Frederiksen, Thomas; Pascual, Jose Ignacio; Peña Gil, Diego (Wiley, 2021)
      Triangulene nanographenes are open-shell molecules with predicted high spin state due to the frustration of their conjugated network. Their long-sought synthesis became recently possible over a metal surface. Here, we ...
    • A One-Step, Versatile Synthesis of Dibenzo [n.2.2] Macrobicyclic Compounds via a Conformation-Directed Macrocyclization Reaction 

      Lobato, Rubén; Veiga, Alberte X.; Pérez-Vázquez, Jaime; Fernández-Nieto, Fernando; Paleo, M. Rita; Sardina, F. Javier (American Chemical Society, 2013)
      A series of dibenzo [n.2.2] bicyclic compounds (n = 2–20) were prepared in one step and good yields starting from dimethyl anthracene-9,10-dicarboxylate. Reduction of the aromatic diester using lithium/naphthalene led to ...
    • Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists 

      Val García, Cristina; Rodríguez García, Carlos; Prieto Díaz, Rubén; Crespo Gavilán, Abel; Azuaje Guerrero, Jhonny Alberto; Carbajales Pérez, Carlos; Majellaro, María; Díaz Holguín, Alejandro; Brea Floriani, José Manuel; Loza García, María Isabel; Gioé Gallo, Claudia; Contino, Marialessandra; Stefanachi, Angela; García Mera, Xerardo Xusto; Estévez Cabanas, Juan Carlos; Gutiérrez de Terán, Hugo; Sotelo, Eddy (ACS Publications, 2022)
      We herein document a large collection of 108 2-amino-4,6-disubstituted-pyrimidine derivatives as potent, structurally simple, and highly selective A1AR ligands. The most attractive ligands were confirmed as antagonists of ...





      Harvesters:Useful links:
      Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contact Us | Send Feedback