Now showing items 33-52 of 384

    • A C60-aryne building block: synthesis of a hybrid all-carbon nanostructure 

      García, D.; Rodríguez-Pérez, L.; Herranz, M.A.; Peña Gil, Diego; Guitián Rivera, Enrique; Bailey, S.; Al-Galiby, Q.; Noori, M.; Lambert, C. J.; Pérez Meirás, María Dolores; Martín, N. (Royal Society of Chemistry, 2016-04-19)
      The synthesis of a [60]fullerene-benzyne building block and its further chemical cycloaddition reaction with graphene has resulted in a new all-carbon hybrid material which has been characterized by TGA, FTIR and Raman ...
    • [C^N]‐Alkenyl Gold(III) Complexes by Proximal Ring‐Opening of (2‐Pyridyl)alkylidenecyclopropanes: Mechanistic Insights 

      González, Jorge A.; Verdugo Leal, Felipe Ignacio; Mascareñas Cid, José Luis; López García, Fernando; Nevado, Cristina (Wiley, 2020)
      Pyridine‐substituted alkylidenecyclopropanes (Py‐ACPs) react with gold(III) salts under mild reaction conditions through an unprecedented, proximal ring‐opening pathway, to generate highly appealing, catalytically active ...
    • Canonical DNA minor groove insertion of bisbenzamidine–Ru(ii) complexes with chiral selectivity 

      Sánchez, Mateo I.; Rama, Gustavo; Calo Lapido, Renata; Ucar, Kübra; Lincoln, Per; Vázquez López, Miguel; Melle-Franco, Manuel; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (Royal Society of Chemistry, 2019)
      We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor ...
    • Catalytic addition of C–H bonds across C–C unsaturated systems promoted by iridium(i) and its group IX congeners 

      Fernández Fernández, David; Mascareñas Cid, José Luis; López García, Fernando (Royal Society of Chemistry, 2020)
      Transition metal-catalyzed hydrocarbonations of unsaturated substrates have emerged as powerful synthetic tools for increasing molecular complexity in an atom-economical manner. Although this field was traditionally dominated ...
    • Catalytic Asymmetric Synthesis of Butenolides and Butyrolactones 

      Mao, Bin; Fañanás Mastral, Martín; Feringa, Ben L. (American Chemical Society, 2017-06-22)
      γ-Butenolides, γ-butyrolactones, and derivatives, especially in enantiomerically pure form, constitute the structural core of numerous natural products which display an impressive range of biological activities which are ...
    • Catalytic Cyclization of o‐Alkynyl Phenethylamines via Osmacyclopropene Intermediates: Direct Access to Dopaminergic 3‐Benzazepines 

      Álvarez Pérez, Andrea; González Rodríguez, Carlos; García Yebra, Cristina; Varela Carrete, Jesús Ángel; Oñate Rodríguez, Enrique; Esteruelas Rodrigo, Miguel Ángel; Saá Rodríguez, Carlos (Wiley, 2015)
      A novel osmium‐catalyzed cyclization of o‐alkynyl phenethylamines to give 3‐benzazepines is reported. The procedure allows the straightforward preparation of a broad range of dopaminergic 3‐benzazepine derivatives. Mechanistic ...
    • Catalytic Lewis Base Additive Enables Selective Copper-Catalyzed Borylative α-C–H Allylation of Alicyclic Amines 

      Pérez Saavedra, Borja; Velasco Rubio, Álvaro; Rivera Chao, Eva; Varela, Jesús A.; Fañanás Mastral, Martín (ACS Publications, 2022)
      Functionalized alicyclic amines are important building blocks for the synthesis of bioactive natural compounds and drugs. Existing methods of functionalization are typically limited to the synthesis of protected amines or ...
    • Chain-branched polyhydroxylated Octahydro-1H-Indoles as potential leads against lysosomal storage diseases 

      Estévez Cabanas, Juan Carlos; González, Marcos A.; Villaverde Cameron-Walker, María del Carmen; Hirokami, Yuki; Kato, Atsushi; Sussman, Fredy Salomon; Reza Ramos, David; Estévez Cabanas, Ramón José (MDPI, 2019)
      Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1H-indole-4,5,6-triols are reported. This study shows the transformation of d-glucose into polyhydroxylated 1-(2-nitrocyclohexane) ...
    • Characterizing aliphatic moieties in hydrocarbons with atomic force microscopy 

      Schuler, Bruno; Zhang, Yunlong; Collazos Suárez, Sara; Fatayer, Shadi; Meyer, Gehrard; Pérez Meirás, María Dolores; Guitián Rivera, Enrique; Harper, Michael R.; Kushnerick, J. Douglas; Peña Gil, Diego; Gross, Leo (Royal Society of Chemistry, 2017)
      We designed and studied hydrocarbon model compounds by high-resolution noncontact atomic force microscopy. In addition to planar polycyclic aromatic moieties, these novel model compounds feature linear alkyl and ...
    • Chemical and biological analysis of 4-acyloxy-3-nitrocoumarins as trypanocidal agents 

      Salgado, Francisco J.; Moncada Basualto, Mauricio; Pozo Martínez, Josué; Liempi, Ana; Kemmerling, Ulrike; Maya, Juan Diego; Jaque, Pablo; Borges, Fernanda; Uriarte Villares, Eugenio; Matos, Maria João Correia Pinto Carvalho de; Olea Azar, Claudio (Elsevier, 2021)
      Chagas disease is the most widespread contagious tropical disease in Latin America, being an important public health problem. Treatments against this disease are still very ineffective, presenting several side effects. ...
    • A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC 

      Calo Lapido, Renata; Penas Tallón, Cristina; Jiménez Balsa, Adrián; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2019)
      We describe the first chemical synthesis of a functional mutant of the DNA binding domain of the oncoprotein MYC, using two alternative strategies which involve either one or two Native Chemical Ligations (NCLs). Both ...
    • Chemo- and Regioselective Lysine Modification on Native Proteins 

      Matos, Maria João Correia Pinto Carvalho de; Oliveira, Bruno L.; Martínez Saéz, Nuria; Guerreiro, Ana; Cal, Pedro M.S.D.; Bertoldo, Jean Borges; Maneiro Rey, María; Perkins, Elizabeth; Howard, Julie A.; Deery, Michael J.; Chalker, Justin M.; Corzana, Francisco; Jiménez Osés, Gonzalo; Bernardes, Gonçalo J.L. (American Chemical Society, 2018)
      Site-selective chemical conjugation of synthetic molecules to proteins expands their functional and therapeutic capacity. Current protein modification methods, based on synthetic and biochemical technologies, can achieve ...
    • Chiral Coalition in Helical Sense Enhancement of Copolymers: The Role of the Absolute Configuration of Comonomers 

      Arias, Sandra; Rodríguez Riego, Rafael; Riguera Vega, Ricardo; Quiñoá Cabana, Emilio; Freire Iribarne, Félix Manuel (American Chemistry Society, 2017-12-14)
      Both the role of the absolute configuration and the tendency of a chiral monomer to promote a certain helical scaffold in a polyphenylacetylene (PPA) —that depends on the conformational composition at the pendant group— ...
    • Chiral gold–PPA nanocomposites with tunable helical sense and morphology 

      Bergueiro Álvarez, Julián; Núñez Martínez, Manuel; Arias López, Sandra; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (Royal Society of Chemistry, 2020)
      A novel type of stimuli-responsive dynamic helical polymer–metal nanoparticle nanocomposite formed by a helical poly(phenylacetylene) (PPA) combined with gold nanoparticles (AuNPs) is described. Thus, several PPA copolymers ...
    • Chiral information harvesting in helical poly(acetylene) derivatives using oligo(p-phenyleneethynylene)s as spacers 

      Fernández Villar, Zulema; Fernández Rodríguez, Berta; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (Royal Society of Chemistry, 2020)
      A chiral harvesting transmission mechanism is described in poly(acetylene)s bearing oligo(p-phenyleneethynylene)s (OPEs) used as rigid achiral spacers and derivatized with chiral pendant groups. The chiral moieties induce ...
    • Chiral nanostructure in polymers under different deposition conditions observed using atomic force microscopy of monolayers: poly(phenylacetylene)s as a case study 

      Freire Iribarne, Félix Manuel; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo (Royal Society of Chemistry, 2016-10-31)
      Dynamic poly(phenylacetylene)s (PPAs) adopt helical structures with different elongation or helical senses depending on the types of pendants. Hence, a good knowledge of the parameters that define their structures becomes ...
    • Chiral Overpass Induction in Dynamic Helical Polymers Bearing Pendant Groups with Two Chiral Centers 

      Suárez Picado, Esteban; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (Wiley, 2020)
      The dynamic behavior of helical polymers bearing pendant groups with two chiral centers was studied. Controlled conformational changes at the chiral units placed either closer to or further away from the main chain promote ...
    • Chiral-to-Chiral Communication in Polymers: A Unique Approach to Control both Helical Sense and Chirality at the Periphery 

      Cobos Cabrera, Scarlet Katherine; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (American Chemical Society, 2018-08-29)
      A novel approach to the classical Sergeants and Soldiers effect, using chiral Sergeants and chiral Soldiers, allows control over both helical and external chirality in helical polymers. In the systems reported here, it is ...
    • Chitosan hydrophobic domains are favoured at low degree of acetylation and molecular weight 

      Novoa Carballal, Ramón; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Elsevier, 2013-04-03)
      The aggregation of chitosan (CS) has been studied as a function of concentration, degree of acetylation (DA), and degree of polymerization (DP) by means of pyrene fluorescence and rheology. Fluorescence experiments show ...
    • Click Chemistry for Drug Delivery Nanosystems 

      Lallana, Enrique; Sousa Hervés, Ana; Fernández Trillo, Francisco (Springer, 2012)
      The purpose of this Expert Review is to discuss the impact of click chemistry in nanosized drug delivery systems. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click ...





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