Now showing items 1-20 of 346

    • Methyl derivatives of tetracyclic psoralen analogues: antiproliferative activity and interaction with DNA 

      Dalla Via, Lisa; Uriarte Villares, Eugenio; Santana Penín, María Lourdes; Marciani Magno, Sebastiano; Gia, Ornella (Arkat USA Inc, 2004)
      A number of new tetracyclic psoralen derivatives were studied. The fourth ring is constituted by cyclopentane (4, 7 and 9), cyclohexane (11, 15 and 18) or benzene (12, 16 and 20) fused to either 4',5' or 3,4 photoreactive ...
    • 3-O-Benzyl-6-O-benzoyl-1,2-Oisopropilidene-5-C-nitromethyl-a-Dglucofuranose 

      Pampín Casal, María Begoña; Valencia Matarranz, Laura; Estévez Cabanas, Juan Carlos; Estévez Cabanas, Ramón José (International Union of Crystallography, 2008)
      The title compound, C24H27NO9, is one of the epimers of the Henry reaction of 3-O-benzyl-6-O-benzoyl-2-O-isopropyl­idene-a-D-glucofuran-5-one with nitro­methane. The conformation of the five membered rings is as expected ...
    • Ethyl 1-O-tert-butyldimethylsilyl-2,3-Oisopropylidene-5-[(20S)-tetrahydropyran2-yloxy]-D-glycero-a-D-manno-heptofuronate 

      González Soengas, Raquel María; Valencia Matarranz, Laura; Estévez Cabanas, Juan Carlos; Estévez Cabanas, Ramón José (International Union of Crystallography, 2008)
      The title compound {systematic name: (2S,3R)-ethyl 3- [(3aS,4R,6S,6aS)-6-tert-butyldimethylsilyloxy-2,2-dimethylperhydrofuro[3,4-d][1,3]dioxol-4-yl]-2-nitro-3-[(S)-tetrahydro-2H-pyran-2-yloxy]propanoate}, C23H41NO10Si, ...
    • Methyl 2-diphenylphosphoryloxy-2-azabicyclo[2.2.1]hept-5-ene-3-exocarboxylate 

      Sousa, Carlos A.D.; Vale, M. Luísa C.; Rodríguez Borges, José E.; García Mera, Xerardo Xusto (International Union of Crystallography, 2009)
      In the title compound, C20H20NO4P, the dihedral angle between the phenyl rings is 68.52 (7) . In the crystal structure, the molecules are linked by a weak C—H(arene) interaction along [010] involving the phenyl CH group ...
    • (1RS,4RS,5RS)-Methyl 2-(3,5-di­nitro­benzo­yl)-2-oxa-3-aza­bi­cyclo­[3.3.0]oct-7-ene-4-carboxyl­ate 

      Sousa, Carlos A.D.; Rodríguez Borges, José E.; Vale, M. Luísa C.; García Mera, Xerardo Xusto (International Union of Crystallography, 2009)
      In organic synthesis, the usual techniques as NMR, mass or infra-red spectrometry and elemental analysis are often not enough for the unequivocally determination of a structure of a compound. When it is possible to ...
    • Tyrosinase inhibitor activity of coumarin-resveratrol hybrids 

      Fais, Antonella; Corda, Marcella; Era, Benedetta; Fadda, M. Benedetta; Matos, Maria João Correia Pinto Carvalho de; Quezada González, Elías Neftalí; Santana Penín, María Lourdes; Picciau, Carmen; Podda, Gianni; Delogu, Giovanna Lucia (MDPI, 2009)
      In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 ...
    • Host-Guest Complexation Studied by Fluorescence Correlation Spectroscopy: Adamantane–Cyclodextrin Inclusion 

      Granadero, Daniel; Bordello Malde, Jorge; Pérez Alvite, María Jesús; Novo Rodríguez, María de la Merced; Al-Soufi, Wajih (MDPI, 2010)
      The host-guest complexation between an Alexa 488 labelled adamantane derivative and β-cyclodextrin is studied by Fluorescence Correlation Spectroscopy (FCS). A 1:1 complex stoichiometry and a high association equilibrium ...
    • Host-guest complexation studied by fluorescence correlation spectroscopy: adamantane–cyclodextrin inclusion 

      Granadero, Daniel; Bordello Malde, Jorge; Pérez Alvite, María Jesús; Novo Rodríguez, María de la Merced; Al-Soufi, Wajih (MDPI, 2010)
      The host-guest complexation between an Alexa 488 labelled adamantane derivative and β-cyclodextrin is studied by Fluorescence Correlation Spectroscopy (FCS). A 1:1 complex stoichiometry and a high association equilibrium ...
    • A ‘click chemistry’ approach to the straightforward synthesis of new 4-aryl-1,2,3-triazolocarbanucleosides 

      Pérez Castro, Isabel; Caamaño Santos, María Olga; Fernández González, Franco; García, Marcos D.; López Santamaría, María del Carmen; Clercq, Erik de (Arkat USA Inc, 2010)
      The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3- triazolyl carbanucleosides of type (±)-10/(±)-11 related to the broad spectrum antiviral agent ribavirin 1 are described. ...
    • Synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-Halo-3-phenylcoumarins 

      Quezada González, Elías Neftalí; Delogu, Giovanna Lucia; Picciau, Carmen; Santana Penín, María Lourdes; Podda, Gianni; Borges, Fernanda; García Morales, Verónica; Viña Castelao, María Dolores; Orallo Cambeiro, Francisco (MDPI, 2010)
      A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant ...
    • Cyclization by Catalytic Ruthenium Carbene Insertion into Csp3-H Bonds 

      Cambeiro Cambeiro, Fermín; López Estévez, Susana; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (Wiley, 2011)
      A novel tandem Ru-catalyzed carbene addition to terminal alkynes/insertion of Csp3–H bonds in alkynyl acetals, ethers and amines has been accomplished under mild conditions. This cascade provides an efficient approach to ...
    • Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery 

      Lallana, Enrique; Fernández Trillo, Francisco; Sousa Hervés, Ana; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Springer, 2012)
      During the last decades, great efforts have been devoted to design polymers for reducing the toxicity, increasing the absorption, and improving the release profile of drugs. Advantage has been also taken from the inherent ...
    • Click Chemistry for Drug Delivery Nanosystems 

      Lallana, Enrique; Sousa Hervés, Ana; Fernández Trillo, Francisco (Springer, 2012)
      The purpose of this Expert Review is to discuss the impact of click chemistry in nanosized drug delivery systems. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click ...
    • Enantioselective Annulation Reactions of Bisenolates Prepared Through Dearomatization Reactions of Aromatic and Heteroaromatic Diesters 

      Pérez-Vázquez, Jaime; Veiga, Alberte X.; Prado, Gustavo; Sardina, F. Javier; Paleo, M. Rita (Wiley, 2012)
      A one‐pot, enantioselective strategy for the dearomatization–annulation of aromatic diesters to give a range of highly functionalized polycyclic molecules with excellent enantioselectivity is presented. This methodology ...
    • PEG-dendritic block copolymers for biomedical applications 

      Sousa Hervés, Ana; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Royal Society of Chemistry, 2012)
      The incorporation of poly(ethylene glycol) (PEG) chains at the focal point of dendrimers results in customizable platforms where the careful selection of the PEG length, the nature of the peripheral groups, and the structure ...
    • Gold(I)‐Catalyzed Intermolecular [2+2] Cycloadditions between Allenamides and Alkenes 

      Faustino, Hélio; Bernal Albert, Paloma; Castedo Expósito, José Luis; López García, Fernando; Mascareñas Cid, José Luis (Wiley, 2012)
      3‐(Propa‐1,2‐dien‐1‐yl)oxazolidin‐2‐one works as an efficient two‐carbon partner in a variety of intermolecular gold‐catalyzed [2+2] cycloadditions to alkenes. The transformation represents a simple and practical entry to ...
    • Temporary Electrostatic Impairment of DNA Recognition: Light‐Driven DNA Binding of Peptide Dimers 

      Jiménez Balsa, Adrián; Pazos Chantrero, Elena; Martínez Albardonedo, Borja; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (Wiley, 2012)
      Appending negatively charged Glu8 tails to a peptide dimer derived from the GCN4 transcription factor leads to an effective suppression of its DNA binding. The specific DNA recognition can be restored by irradiation with ...
    • Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes 

      Sánchez López, Mateo Isidro; Vázquez Vázquez, Olalla; Martínez Costas, José Manuel; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2012)
      Bisbenzamidines are an important family of minor groove DNA-binding agents. We present a one-step synthesis of aromatic aza-bisbenzamidines that allows straightforward and versatile access to a large number of these ...
    • Commercial bee pollen with different geographical origins: A comprehensive approach 

      Nogueira, Carla; Iglesias Becerra, Antonio; Feás Sánchez, Xesús; Estevinho, Leticia M. (MDPI, 2012)
      Since the primordial of humanity, pollen has been considered a good source of nutrients and energy. Its promising healing properties have also been referred to. The present study aimed to characterize, for the first time, ...
    • Comprehensive study of honey with protected denomination of origin and contribution to the enhancement of legal specifications 

      Iglesias Becerra, Antonio; Feás Sánchez, Xesús; Rodrigues, Sandra; Seijas Vázquez, Julio Antonio; Vázquez Tato, María del Pilar; Dias, Luis G.; Estevinho, Leticia M. (MDPI, 2012)
      In this study the characterization of a total of 60 honey samples with Protected Denomination of Origin (PDO) collected over three harvests (2009–2011, inclusive), from the Northeast of Portugal was carried out based on ...





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