Browsing QO-Artigos by Issue Date
Now showing items 1-20 of 325
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Methyl derivatives of tetracyclic psoralen analogues: antiproliferative activity and interaction with DNA
(Arkat USA Inc, 2004)A number of new tetracyclic psoralen derivatives were studied. The fourth ring is constituted by cyclopentane (4, 7 and 9), cyclohexane (11, 15 and 18) or benzene (12, 16 and 20) fused to either 4',5' or 3,4 photoreactive ... -
3-O-Benzyl-6-O-benzoyl-1,2-Oisopropilidene-5-C-nitromethyl-a-Dglucofuranose
(International Union of Crystallography, 2008)The title compound, C24H27NO9, is one of the epimers of the Henry reaction of 3-O-benzyl-6-O-benzoyl-2-O-isopropylidene-a-D-glucofuran-5-one with nitromethane. The conformation of the five membered rings is as expected ... -
Ethyl 1-O-tert-butyldimethylsilyl-2,3-Oisopropylidene-5-[(20S)-tetrahydropyran2-yloxy]-D-glycero-a-D-manno-heptofuronate
(International Union of Crystallography, 2008)The title compound {systematic name: (2S,3R)-ethyl 3- [(3aS,4R,6S,6aS)-6-tert-butyldimethylsilyloxy-2,2-dimethylperhydrofuro[3,4-d][1,3]dioxol-4-yl]-2-nitro-3-[(S)-tetrahydro-2H-pyran-2-yloxy]propanoate}, C23H41NO10Si, ... -
Methyl 2-diphenylphosphoryloxy-2-azabicyclo[2.2.1]hept-5-ene-3-exocarboxylate
(International Union of Crystallography, 2009)In the title compound, C20H20NO4P, the dihedral angle between the phenyl rings is 68.52 (7) . In the crystal structure, the molecules are linked by a weak C—H(arene) interaction along [010] involving the phenyl CH group ... -
(1RS,4RS,5RS)-Methyl 2-(3,5-dinitrobenzoyl)-2-oxa-3-azabicyclo[3.3.0]oct-7-ene-4-carboxylate
(International Union of Crystallography, 2009)In organic synthesis, the usual techniques as NMR, mass or infra-red spectrometry and elemental analysis are often not enough for the unequivocally determination of a structure of a compound. When it is possible to ... -
Tyrosinase inhibitor activity of coumarin-resveratrol hybrids
(MDPI, 2009)In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 ... -
Host-Guest Complexation Studied by Fluorescence Correlation Spectroscopy: Adamantane–Cyclodextrin Inclusion
(MDPI, 2010)The host-guest complexation between an Alexa 488 labelled adamantane derivative and β-cyclodextrin is studied by Fluorescence Correlation Spectroscopy (FCS). A 1:1 complex stoichiometry and a high association equilibrium ... -
Host-guest complexation studied by fluorescence correlation spectroscopy: adamantane–cyclodextrin inclusion
(MDPI, 2010)The host-guest complexation between an Alexa 488 labelled adamantane derivative and β-cyclodextrin is studied by Fluorescence Correlation Spectroscopy (FCS). A 1:1 complex stoichiometry and a high association equilibrium ... -
A ‘click chemistry’ approach to the straightforward synthesis of new 4-aryl-1,2,3-triazolocarbanucleosides
(Arkat USA Inc, 2010)The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3- triazolyl carbanucleosides of type (±)-10/(±)-11 related to the broad spectrum antiviral agent ribavirin 1 are described. ... -
Synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-Halo-3-phenylcoumarins
(MDPI, 2010)A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant ... -
Cyclization by Catalytic Ruthenium Carbene Insertion into Csp3-H Bonds
(Wiley, 2011)A novel tandem Ru-catalyzed carbene addition to terminal alkynes/insertion of Csp3–H bonds in alkynyl acetals, ethers and amines has been accomplished under mild conditions. This cascade provides an efficient approach to ... -
Formation of Indoles, Dihydroisoquinolines and Dihydroquinolines by Ruthenium-Catalyzed Heterocyclizations
(Thieme, 2012)Indoles, dihydroisoquinolines and dihydroquinolines were efficiently prepared by ruthenium-catalyzed heterocyclizations of aromatic homo- and bis-homopropargyl amines/amides in the presence of an amine/ammonium base-acid ... -
Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery
(Springer, 2012)During the last decades, great efforts have been devoted to design polymers for reducing the toxicity, increasing the absorption, and improving the release profile of drugs. Advantage has been also taken from the inherent ... -
Click Chemistry for Drug Delivery Nanosystems
(Springer, 2012)The purpose of this Expert Review is to discuss the impact of click chemistry in nanosized drug delivery systems. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click ... -
Tandem Brønsted Acid Promoted and Nazarov Carbocyclizations of Enyneacetals to Hydroazulenones
(Wiley, 2012)A new and efficient metal-free entry to hydroazulenones is reported. Enyneacetals were easily converted into hydroazulene skeletons by tandem Brønsted-acidpromoted carbocyclizations followed by stereospecific Nazarov ... -
Enantioselective Annulation Reactions of Bisenolates Prepared Through Dearomatization Reactions of Aromatic and Heteroaromatic Diesters
(Wiley, 2012)A one‐pot, enantioselective strategy for the dearomatization–annulation of aromatic diesters to give a range of highly functionalized polycyclic molecules with excellent enantioselectivity is presented. This methodology ... -
PEG-dendritic block copolymers for biomedical applications
(Royal Society of Chemistry, 2012)The incorporation of poly(ethylene glycol) (PEG) chains at the focal point of dendrimers results in customizable platforms where the careful selection of the PEG length, the nature of the peripheral groups, and the structure ... -
Enhancing adverse drug event detection in electronic health records using molecular structure similarity: application to pancreatitis
(PLOS, 2012)Background Adverse drug events (ADEs) detection and assessment is at the center of pharmacovigilance. Data mining of systems, such as FDA’s Adverse Event Reporting System (AERS) and more recently, Electronic Health Records ... -
Gold(I)‐Catalyzed Intermolecular [2+2] Cycloadditions between Allenamides and Alkenes
(Wiley, 2012)3‐(Propa‐1,2‐dien‐1‐yl)oxazolidin‐2‐one works as an efficient two‐carbon partner in a variety of intermolecular gold‐catalyzed [2+2] cycloadditions to alkenes. The transformation represents a simple and practical entry to ... -
In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains
(American Chemical Society, 2012)Chemical derivatization of nucleic stains such as ethidium bromide or DAPI with tailored, photoresponsive caging groups, allows for “on demand” spatiotemporal control of their in vivo nucleic acid binding, as well as for ...