Now showing items 1-20 of 346

    • 1,7-Naphthodiyne: a new platform for the synthesis of novel, sterically congested PAHs 

      Pozo Míguez, Iago; Cobas Martínez, Agustín; Peña Gil, Diego; Guitián Rivera, Enrique; Pérez Meirás, María Dolores (Royal Society of Chemistry, 2016-03-17)
      The synthesis of an efficient precursor of the novel 1,7-naphthodiyne synthon is reported. Preliminary experiments demonstrate the usefulness of this platform for the synthesis of sterically congested polyarenes, such as ...
    • 1D to 2D Self Assembly of Cyclic Peptides 

      Insua López, Ignacio; Montenegro García, Javier (American Chemical Society, 2020)
      Despite recent developments in two-dimensional self-assembly, most supramolecular 2D materials are assembled by tedious methodologies, with complex surface chemistry and small sizes. We here report d/l-alternating cyclic ...
    • (1RS,4RS,5RS)-Methyl 2-(3,5-di­nitro­benzo­yl)-2-oxa-3-aza­bi­cyclo­[3.3.0]oct-7-ene-4-carboxyl­ate 

      Sousa, Carlos A.D.; Rodríguez Borges, José E.; Vale, M. Luísa C.; García Mera, Xerardo Xusto (International Union of Crystallography, 2009)
      In organic synthesis, the usual techniques as NMR, mass or infra-red spectrometry and elemental analysis are often not enough for the unequivocally determination of a structure of a compound. When it is possible to ...
    • [2+1] Cycloaddition of Catalytic Ruthenium Vinyl Carbenes: A Stereoselective Controlled Access to (Z)- and (E)-Vinyl Epoxypyrrolidines 

      Padín Santos, Damián; Cambeiro Cambeiro, Fermín; Fañanás Mastral, Martín; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (American Chemical Society, 2016)
      Aza-alkynals undergo a cyclization reaction with diazo compounds in the presence of catalytic amounts of Cp*RuCl(cod) to afford vinyl epoxypyrrolidines, valuable building blocks for the synthesis of biologically active ...
    • 3-O-Benzyl-6-O-benzoyl-1,2-Oisopropilidene-5-C-nitromethyl-a-Dglucofuranose 

      Pampín Casal, María Begoña; Valencia Matarranz, Laura; Estévez Cabanas, Juan Carlos; Estévez Cabanas, Ramón José (International Union of Crystallography, 2008)
      The title compound, C24H27NO9, is one of the epimers of the Henry reaction of 3-O-benzyl-6-O-benzoyl-2-O-isopropyl­idene-a-D-glucofuran-5-one with nitro­methane. The conformation of the five membered rings is as expected ...
    • [4+2] and [4+3] catalytic cycloadditions of allenes 

      López García, Fernando; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2014)
      This feature review describes the development of catalytic [4+2] and [4+3] cycloadditions of allenes, as efficient and practical methodologies for assembling six and seven-membered cyclic systems. The different methodologies ...
    • 8‐Aminomethyl‐7‐hydroxy‐4‐methylcoumarins as Multitarget Leads for Alzheimer's Disease 

      Domínguez, José L.; Fernández-Nieto, Fernando; Brea Floriani, José Manuel; CATTO, Marco; Paleo, M. Rita; Porto, Silvia; Sardina, F. Javier; Castro, Marian; PISANI, Leonardo; Carotti, Angelo; Soto-Otero, Ramón; Méndez-Álvarez, Estefanía; Villaverde Cameron-Walker, María del Carmen; Sussman, Fredy Salomon (Wiley, 2016-07-22)
      This work is part of our ongoing research in the discovery of multitarget therapeutic agents for Alzheimer's disease (AD). A literature screening, based on our recently proposed pharmacophore, led to the identification of ...
    • Activity of the β-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii 

      Vázquez Ucha, Juan Carlos; Maneiro Rey, María; Martínez Guitián, Marta; Buynak, John; Bethel, Christopher R.; Bonomo, Roberto A.; Bou, Germán; Poza, Margarita; González Bello, Concepción; Beceiro Casas, Alejandro (American Society for Microbiology, 2017)
      The number of infections caused by Gram-negative pathogens carrying carbapenemases is increasing, and the group of carbapenem-hydrolyzing class D β-lactamases (CHDLs) is especially problematic. Several clinically important ...
    • Adenosine Receptor Ligands: Coumarin–Chalcone Hybrids as Modulating Agents on the Activity of hARs 

      Vázquez Rodríguez, Saleta; Vilar, Santiago; Kachler, Sonja; Klotz, Karl-Norbert; Uriarte Villares, Eugenio; Borges, Fernanda; Matos, Maria João Correia Pinto Carvalho de (MDPI, 2020)
      Adenosine receptors (ARs) play an important role in neurological and psychiatric disorders such as Alzheimer’s disease, Parkinson’s disease, epilepsy and schizophrenia. The different subtypes of ARs and the knowledge on ...
    • Advances in lanthanide‐based luminescent peptide probes for monitoring the activity of kinase and phosphatase 

      Pazos Chantrero, Elena; Vázquez Sentís, Marco Eugenio (Wiley, 2014)
      Signaling pathways based on protein phosphorylation and dephosphorylation play critical roles in the orchestration of complex biochemical events and form the core of most signaling pathways in cells (i.e. cell cycle ...
    • Allenes and Derivatives in Gold(I)- and Platinum(II)-Catalyzed Formal Cycloadditions 

      Mascareñas Cid, José Luis; Varela Sandá, Iván; López García, Fernando (American Chemical Society, 2019)
      Conspectus Cycloaddition reactions, by involving the formation of at least two bonds and one cycle in a single operation, represent one of the more practical ways to assemble carbo- and heterocyclic structures from ...
    • Amide-Directed Formation of Five-Coordinate Osmium Alkylidenes from Alkynes 

      Casanova González, Noelia; Esteruelas, Miguel A.; Larramona, Carmen; Mascareñas Cid, José Luis; Gulías Costa, Moisés (American Chemical Society, 2015-12-31)
      The amide-directed synthesis of five-coordinate osmium alkylidene derivatives from alkynes is reported. These types of complexes, which have been elusive until now because of the tendency of osmium to give hydride alkylidyne ...
    • An aquaporin 4 antisense oligonucleotide loaded, brain targeted nanoparticulate system design 

      Kozlu, S.; Caban, Secil; Yerlikaya, F.; Fernández Megía, Eduardo; Novoa Carballal, Ramón; Riguera Vega, Ricardo; Yemisci, Muge; Gursoy-Ozdemir, Yasemin; Dalkara, Turgay; Couvreur, Partick; Capan, Yilmaz (Avoxa - Mediengruppe Deutscher Apotheker GmbH, 2014-05)
      Aquaporins (AQPs), members of the water-channel protein family, are highly expressed in brain tissue especially in astrocytic end-feet. They are important players for water hemostasis during development of cytotoxic as ...
    • An automated method to find reaction mechanisms and solve the kinetics in organometallic catalysis 

      Varela Carrete, Jesús Ángel; Vázquez Rodríguez, Saulo Angel; Martínez Núñez, Emilio (Royal Society of Chemistry, 2017)
      A novel computational method is proposed in this work for use in discovering reaction mechanisms and solving the kinetics of transition metal-catalyzed reactions. The method does not rely on either chemical intuition or ...
    • Anion recognition and induced self-assembly of an alpha,gamma-cyclic peptide to form spherical clusters 

      Rodríguez-Vázquez, Nuria; Amorín López, Manuel; Granja Guillán, Juan Ramón; Alfonso, Ignacio (Wiley, 2016-03-21)
      A cyclic octapeptide composed of hydroxy-functionalized γ-amino acids folds in a "V-shaped" conformation that allows the selective recognition of anions such as chloride, nitrate, and carbonate. The process involves the ...
    • Anion Recognition as a Supramolecular Switch of Cell Internalization 

      Rodríguez Villar, Jéssica; Mosquera Mosquera, Jesús; Rodríguez Couceiro, José; Nitschke, Jonathan R.; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (American Chemical Society, 2016)
      The cell internalization of designed oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular host. This host binds specifically ...
    • Antiangiogenic effects of coumarins against cancer: from chemistry to medicine 

      Majnooni, Mohammad Bagher; Fakhri, Sajad; Smeriglio, Antonella; Trombetta, Domenico; Croley, Courtney R.; Bhattacharyya, Piyali; Sobarzo Sánchez, Eduardo Marcelo; Farzaei, Mohammad Hosein; Bishayee, Anupam (MDPI, 2019)
      Angiogenesis, the process of formation and recruitment of new blood vessels from pre-existing vessels, plays an important role in the development of cancer. Therefore, the use of antiangiogenic agents is one of the most ...
    • Antibacterial activity and molecular docking studies of a selected series of Hydroxy-3-arylcoumarins 

      Pisano, Maria Barbara; Kumar, Amit; Medda, Rosaria Medda; Gatto, Gianluca; Pal, Rajesh; Fais, Antonella; Era, Benedetta; Cosentino, Sofia; Uriarte Villares, Eugenio; Santana Penín, María Lourdes; Pintus, Francesca; Matos, Maria João Correia Pinto Carvalho de (MDPI, 2019)
      Antibiotic resistance is one of the main public health concerns of this century. This resistance is also associated with oxidative stress, which could contribute to the selection of resistant bacterial strains. Bearing ...
    • Antibiotic adjuvants – A strategy to unlock bacterial resistance to antibiotics 

      González Bello, Concepción (Elsevier, 2017-08-14)
      Resistance to available antibiotics in pathogenic bacteria is currently a global challenge since the number of strains that are resistant to multiple types of antibiotics has increased dramatically each year and has spread ...
    • Applied Biological and Physicochemical Activity of Isoquinoline Alkaloids: Oxoisoaporphine and Boldine 

      Sobarzo Sánchez, Eduardo Marcelo; González Soto, Patricio; Valdés Rivera, Cristóbal; Sánchez, Georgina; Hidalgo, María Eliana (MDPI, 2012)
      The aim of this study was to determine the electronic influence of substituent groups and annelated rings such as oxazole-oxazinone on the physicochemical and photoprotection, antioxidant capacity, toxicity and singlet ...





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