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Recruitment of RNA molecules by connexin RNA-binding motifs: Implication in RNA and DNA transport through microvesicles and exosomes
(Elsevier, 2017-04)
Connexins (Cxs) are integral membrane proteins that form high-conductance plasma membrane channels, allowing communication from cell to cell (via gap junctions) and from cells to the extracellular environment (via ...
Gold(I)‐Catalyzed Intermolecular [2+2] Cycloadditions between Allenamides and Alkenes
(Wiley, 2012)
3‐(Propa‐1,2‐dien‐1‐yl)oxazolidin‐2‐one works as an efficient two‐carbon partner in a variety of intermolecular gold‐catalyzed [2+2] cycloadditions to alkenes. The transformation represents a simple and practical entry to ...
Temporary Electrostatic Impairment of DNA Recognition: Light‐Driven DNA Binding of Peptide Dimers
(Wiley, 2012)
Appending negatively charged Glu8 tails to a peptide dimer derived from the GCN4 transcription factor leads to an effective suppression of its DNA binding. The specific DNA recognition can be restored by irradiation with ...
Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes
(Royal Society of Chemistry, 2012)
Bisbenzamidines are an important family of minor groove DNA-binding agents. We present a one-step synthesis of aromatic aza-bisbenzamidines that allows straightforward and versatile access to a large number of these ...
Transition Metal-mediated Reactions in Biological Media
(Swiss Chemical Society, 2018)
Transition-metal catalysis has changed the way in which chemical reactions can be accomplished. While most metal-catalyzed reactions have been achieved in organic solvents, recent work has demonstrated that many of these ...
Single‐Molecule Approach to DNA Minor‐Groove Association Dynamics
(Wiley, 2012)
Getting in the groove: Fluorescence correlation spectroscopy reveals that the dynamics of the association process of the bisbenzamidine minor‐groove binder BBA‐OG (blue with green star, see scheme) to dsDNA is not controlled ...
Sequence‐Selective DNA Recognition with Peptide–Bisbenzamidine Conjugates
(Wiley, 2013)
Transcription factors (TFs) are specialized proteins that play a key role in the regulation of genetic expression. Their mechanism of action involves the interaction with specific DNA sequences, which usually takes place ...
Rhodium(III)-catalyzed intramolecular annulations involving amide-directed C–H activations: synthetic scope and mechanistic studies
(Royal Society of Chemistry, 2013)
Alkyne tethered benzamides undergo rhodium(III)-catalyzed intramolecular annulations to give tricyclic isoquinoline derivatives in good yields. DFT calculations suggest that the reaction mechanism involves a migratory ...
Gold(I)‐Catalyzed Cascade Cycloadditions between Allenamides and Carbonyl‐Tethered Alkenes: An Enantioselective Approach to Oxa‐Bridged Medium‐Sized Carbocycles
(Wiley, 2013)
Gold standard: Allenamides react with aldehydes or ketones having γ, δ, or ε alkenyl groups, upon activation with suitable gold catalysts, to provide oxa-bridged systems containing seven- to nine-membered carbocycles, in ...
[4+2] and [4+3] catalytic cycloadditions of allenes
(Royal Society of Chemistry, 2014)
This feature review describes the development of catalytic [4+2] and [4+3] cycloadditions of allenes, as efficient and practical methodologies for assembling six and seven-membered cyclic systems. The different methodologies ...