Polysaccharide-based aerogel microspheres for oral drug delivery
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Título: | Polysaccharide-based aerogel microspheres for oral drug delivery |
Autor/a: | García González, Carlos Alberto Jin, Ming Gerth, J. Álvarez Lorenzo, Carmen Isabel Smirnova, I. |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Farmacia e Tecnoloxía Farmacéutica |
Palabras chave: | Polysaccharide-based aerogel | Ketoprofen | Benzoic acid | Supercritical impregnation | Drug release kinetics | |
Data: | 2015-03-06 |
Editor: | Elsevier |
Cita bibliográfica: | C.A. García-González, M. Jin, J. Gerth, C. Alvarez-Lorenzo, I. Smirnova, Polysaccharide-based aerogel microspheres for oral drug delivery, Carbohydrate Polymers, Volume 117, 6 March 2015, Pages 797-806, ISSN 0144-8617, http://dx.doi.org/10.1016/j.carbpol.2014.10.045 |
Resumo: | Polysaccharide-based aerogels in the form of microspheres were investigated as carriers of poorly water soluble drugs for oral administration. These bio-based carriers may combine the biocompatibility of polysaccharides and the enhanced drug loading capacity of dry aerogels. Aerogel microspheres from starch, pectin and alginate were loaded with ketoprofen (anti-inflammatory drug) and benzoic acid (used in the management of urea cycle disorders) via supercritical CO2-assisted adsorption. Amount of drug loaded depended on the aerogel matrix structure and composition and reached values up to 1.0 × 10−3 and 1.7 × 10−3 g/m2 for ketoprofen and benzoic acid in starch microspheres. After impregnation, drugs were in the amorphous state in the aerogel microspheres. Release behavior was evaluated in different pH media (pH 1.2 and 6.8). Controlled drug release from pectin and alginate aerogel microspheres fitted Gallagher–Corrigan release model (R2 > 0.99 in both cases), with different relative contribution of erosion and diffusion mechanisms depending on the matrix composition. Release from starch aerogel microspheres was driven by dissolution, fitting the first-order kinetics due to the rigid starch aerogel structure, and showed different release rate constant (k1) depending on the drug (0.075 and 0.160 min−1 for ketoprofen and benzoic acid, respectively). Overall, the results point out the possibilities of tuning drug loading and release by carefully choosing the polysaccharide used to prepare the aerogels. |
Descrición: | NOTICE: this is the author’s version of a work that was accepted for publication in Carbohydrate polymers. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers
Volume 117, 6 March 2015, Pages 797–806, doi:10.1016/j.carbpol.2014.10.045 |
Versión do editor: | http://dx.doi.org/10.1016/j.carbpol.2014.10.045 |
URI: | http://hdl.handle.net/10347/12302 |
DOI: | 10.1016/j.carbpol.2014.10.045 |
ISSN: | 0144-8617 |
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