Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates
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Title: | Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates |
Author: | Mosquera Mosquera, Jesús Sánchez López, Mateo Isidro Valero, Julián Mendoza, Javier de Vázquez Sentís, Marco Eugenio Mascareñas Cid, José Luis |
Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Date of Issue: | 2015-02-18 |
Publisher: | Royal Society of Chemistry |
Citation: | Mosquera, J., Sánchez M. I., Valero, J., de Mendoza, J., Vázquez, M. E., Mascareñas, J. L. (2015), Sequence-Selective DNA Binding with Cell-Permeable Oligoguanidinium-Peptide Conjugates. ChemComm., 51, 4811-4814 [doi: 10.1039/C4CC09525A]. |
Abstract: | Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract. In addition to stabilizing the complex with the target DNA, the oligoguanidinium unit also endows the conjugate with cell internalization properties |
Description: | NOTICE: This is the peer reviewed version of the following article: Mosquera, J., Sánchez M. I., Valero, J., de Mendoza, J., Vázquez, M. E., Mascareñas, J. L. (2015), Sequence-Selective DNA Binding with Cell-Permeable Oligoguanidinium-Peptide Conjugates. ChemComm., 51, 4811-4814 [doi: 10.1039/C4CC09525A]. This article may be used for non-commercial purposes in accordance with RSC Terms and Conditions for self-archiving |
Publisher version: | http://dx.doi.org/10.1039/C4CC09525A |
URI: | http://hdl.handle.net/10347/12546 |
DOI: | 10.1039/C4CC09525A |
ISSN: | 1359-7345 |
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