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dc.contributor.authorVarela Lema, María Leonor
dc.contributor.authorTaioli, Emanuela
dc.contributor.authorRuano Raviña, Alberto
dc.contributor.authorBarros Dios, Juan Miguel
dc.contributor.authorAnantharaman, Devasena
dc.contributor.authorBenhamou, Simone
dc.contributor.authorBoccia, Stefania
dc.contributor.authorBhisey, Rajani A.
dc.contributor.authorCadoni, Gabriella
dc.contributor.authorCapoluongo, Ettore
dc.contributor.authorChen, Chien-Jen
dc.contributor.authorFoulkes, William D.
dc.contributor.authorGoloni Bertollo, Eny Maria
dc.contributor.authorHatagima, Ana
dc.contributor.authorHayes, Richard B.
dc.contributor.authorKatoh, Takahiko
dc.contributor.authorKoifman, Sergio
dc.contributor.authorLazarus, Phillip
dc.contributor.authorManni, Johannes J.
dc.contributor.authorMahimkar, Manoj
dc.contributor.authorMorita, Shunji
dc.contributor.authorPark, Jong
dc.contributor.authorPark, Kwang-Kyun
dc.contributor.authorPavarino Bertelli, Erika Cristina
dc.contributor.authorRibeiro, Enilze Maria de Souza Fonseca
dc.contributor.authorRoy, Bidyut
dc.contributor.authorSpitz, Margaret R.
dc.contributor.authorStrange, Richard C.
dc.contributor.authorWei, Qingyi
dc.contributor.authorRagin, Camille C.
dc.date.accessioned2015-06-19T08:41:17Z
dc.date.available2015-06-19T08:41:17Z
dc.date.issued2008
dc.identifier.citationVarela-Lema, L., Taioli, E., Ruano-Ravina, A., Barros-Dios, J.M., Anantharaman, D., Benhamou, S., Boccia, S., Bhisey, R.A., Cadoni, G., Capoluongo, E., Chen, C.J., Foulkes, W., Goloni-Bertollo, E.M., Hatagima, A., Hayes, R.B., Katoh, T., Koifman, S., Lazarus, P., Manni, J.J., Mahimkar, M., Morita, S., Park, J., Park, K.K., Pavarino Bertelli, E.C., de Souza Fonseca Ribeiro, E.M., Roy, B., Spitz, M.R., Strange, R.C., Wei, Q., Ragin, C.C. (2008). Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review. "Genetics in Medicine", 10(6), 369–384
dc.identifier.issn1098-3600
dc.identifier.otherE-ISSN 1530-0366
dc.identifier.urihttp://hdl.handle.net/10347/13418
dc.description.abstractThe association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html ). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 or [infi]m2m2: 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer.
dc.language.isoeng
dc.publisherNature Publishing Group
dc.subjectGSTM1
dc.subjectCYP1A1
dc.subjectOral and pharyngeal cancer; Epidemiology; meta
dc.subjectPooled analysis
dc.subject.classificationMaterias::Investigación::32 Ciencias médicas::3202 Epidemologia
dc.subject.classificationMaterias::Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320102 Genética clínica
dc.titleMeta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancer: a HuGE-GSEC review
dc.typejournal article
dc.identifier.doi10.1097/GIM.0b013e3181770196
dc.relation.publisherversionhttp://dx.doi.org/10.1097/GIM.0b013e3181770196
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía e Saúde Pública


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