Mostrar o rexistro simple do ítem
dc.contributor.author | Varela Lema, María Leonor |
dc.contributor.author | Taioli, Emanuela |
dc.contributor.author | Ruano Raviña, Alberto |
dc.contributor.author | Barros Dios, Juan Miguel |
dc.contributor.author | Anantharaman, Devasena |
dc.contributor.author | Benhamou, Simone |
dc.contributor.author | Boccia, Stefania |
dc.contributor.author | Bhisey, Rajani A. |
dc.contributor.author | Cadoni, Gabriella |
dc.contributor.author | Capoluongo, Ettore |
dc.contributor.author | Chen, Chien-Jen |
dc.contributor.author | Foulkes, William D. |
dc.contributor.author | Goloni Bertollo, Eny Maria |
dc.contributor.author | Hatagima, Ana |
dc.contributor.author | Hayes, Richard B. |
dc.contributor.author | Katoh, Takahiko |
dc.contributor.author | Koifman, Sergio |
dc.contributor.author | Lazarus, Phillip |
dc.contributor.author | Manni, Johannes J. |
dc.contributor.author | Mahimkar, Manoj |
dc.contributor.author | Morita, Shunji |
dc.contributor.author | Park, Jong |
dc.contributor.author | Park, Kwang-Kyun |
dc.contributor.author | Pavarino Bertelli, Erika Cristina |
dc.contributor.author | Ribeiro, Enilze Maria de Souza Fonseca |
dc.contributor.author | Roy, Bidyut |
dc.contributor.author | Spitz, Margaret R. |
dc.contributor.author | Strange, Richard C. |
dc.contributor.author | Wei, Qingyi |
dc.contributor.author | Ragin, Camille C. |
dc.date.accessioned | 2015-06-19T08:41:17Z |
dc.date.available | 2015-06-19T08:41:17Z |
dc.date.issued | 2008 |
dc.identifier.citation | Varela-Lema, L., Taioli, E., Ruano-Ravina, A., Barros-Dios, J.M., Anantharaman, D., Benhamou, S., Boccia, S., Bhisey, R.A., Cadoni, G., Capoluongo, E., Chen, C.J., Foulkes, W., Goloni-Bertollo, E.M., Hatagima, A., Hayes, R.B., Katoh, T., Koifman, S., Lazarus, P., Manni, J.J., Mahimkar, M., Morita, S., Park, J., Park, K.K., Pavarino Bertelli, E.C., de Souza Fonseca Ribeiro, E.M., Roy, B., Spitz, M.R., Strange, R.C., Wei, Q., Ragin, C.C. (2008). Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review. "Genetics in Medicine", 10(6), 369–384 |
dc.identifier.issn | 1098-3600 |
dc.identifier.other | E-ISSN 1530-0366 |
dc.identifier.uri | http://hdl.handle.net/10347/13418 |
dc.description.abstract | The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html ). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 or [infi]m2m2: 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer. |
dc.language.iso | eng |
dc.publisher | Nature Publishing Group |
dc.subject | GSTM1 |
dc.subject | CYP1A1 |
dc.subject | Oral and pharyngeal cancer; Epidemiology; meta |
dc.subject | Pooled analysis |
dc.subject.classification | Materias::Investigación::32 Ciencias médicas::3202 Epidemologia |
dc.subject.classification | Materias::Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320102 Genética clínica |
dc.title | Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancer: a HuGE-GSEC review |
dc.type | journal article |
dc.identifier.doi | 10.1097/GIM.0b013e3181770196 |
dc.relation.publisherversion | http://dx.doi.org/10.1097/GIM.0b013e3181770196 |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía e Saúde Pública |
Ficheiros no ítem
Este ítem aparece na(s) seguinte(s) colección(s)
-
PRSP-Artigos [373]