Surface-enhanced raman scattering surface selection rules for the proteomic liquid biopsy in real samples: Efficient detection of the oncoprotein c-MYC
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Title: | Surface-enhanced raman scattering surface selection rules for the proteomic liquid biopsy in real samples: Efficient detection of the oncoprotein c-MYC |
Author: | Pazos Chantrero, Elena García-Algar, Manuel Penas Tallón, Cristina Nazarenus, Moritz Torruella, Arnau Pazos-Pérez, Nicolás Guerrini, Luca Vázquez Sentís, Marco Eugenio García-Rico, Eduardo Mascareñas Cid, José Luis Álvarez-Puebla, Ramón A. |
Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Subject: | Blood-based biomarkers | Diagnosis | Cancers | SERS | |
Date of Issue: | 2016-10-12 |
Publisher: | American Chemical Society |
Citation: | J. Am. Chem. Soc., 2016, 138 (43), pp 14206–14209 |
Abstract: | Blood-based biomarkers (liquid biopsy) offer extremely valuable tools for the noninvasive diagnosis and monitoring of tumors. The protein c-MYC, a transcription factor that has been shown to be deregulated in up to 70% of human cancers, can be used as a robust proteomic signature for cancer. Herein, we developed a rapid, highly specific, and sensitive surface-enhanced Raman scattering (SERS) assay for the quantification of c-MYC in real blood samples. The sensing scheme relies on the use of specifically designed hybrid plasmonic materials and their bioderivatization with a selective peptidic receptor modified with a SERS transducer. Peptide/c-MYC recognition events translate into measurable alterations of the SERS spectra associated with a molecular reorientation of the transducer, in agreement with the surface selection rules. The efficiency of the sensor is demonstrated in cellular lines, healthy donors and a cancer patient |
Description: | NOTICE: This is the peer reviewed version of the following article: Elena Pazos, Manuel García-Algar,
Cristina Penas, Moritz Nazarenus, Arnau Torruella, Nicolas Pazos-Perez, Luca Guerrini, M. Eugenio
Vázquez, Eduardo Garcia-Rio*, José L. Macareñas* and Ramon A. Alvarez-Puebla* (2016), SERS Surface
Selection Rules for the Proteomic Liquid Biopsy in Real Samples: Efficient Detection of the Oncoprotein cMYC.
J. Am. Chem. Soc., 138, 14206-14209 [DOI: 10.1021/jacs.6b08957]. This article may be used for
non-commercial purposes in accordance with ACS Publications Terms and Conditions for self-archiving |
Publisher version: | http://dx.doi.org/10.1021/jacs.6b08957 |
URI: | http://hdl.handle.net/10347/15020 |
DOI: | 10.1021/jacs.6b08957 |
ISSN: | 0002-7863 |
E-ISSN: | 1520-5126 |
Rights: | © American Chemical Society |
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