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dc.contributor.authorPazos Chantrero, Elena
dc.contributor.authorGarcía-Algar, Manuel
dc.contributor.authorPenas Tallón, Cristina
dc.contributor.authorNazarenus, Moritz
dc.contributor.authorTorruella, Arnau
dc.contributor.authorPazos-Pérez, Nicolás
dc.contributor.authorGuerrini, Luca
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorGarcía-Rico, Eduardo
dc.contributor.authorMascareñas Cid, José Luis
dc.contributor.authorÁlvarez-Puebla, Ramón A.
dc.identifier.citationJ. Am. Chem. Soc., 2016, 138 (43), pp 14206–14209
dc.descriptionNOTICE: This is the peer reviewed version of the following article: Elena Pazos, Manuel García-Algar, Cristina Penas, Moritz Nazarenus, Arnau Torruella, Nicolas Pazos-Perez, Luca Guerrini, M. Eugenio Vázquez, Eduardo Garcia-Rio*, José L. Macareñas* and Ramon A. Alvarez-Puebla* (2016), SERS Surface Selection Rules for the Proteomic Liquid Biopsy in Real Samples: Efficient Detection of the Oncoprotein cMYC. J. Am. Chem. Soc., 138, 14206-14209 [DOI: 10.1021/jacs.6b08957]. This article may be used for non-commercial purposes in accordance with ACS Publications Terms and Conditions for self-archiving
dc.description.abstractBlood-based biomarkers (liquid biopsy) offer extremely valuable tools for the noninvasive diagnosis and monitoring of tumors. The protein c-MYC, a transcription factor that has been shown to be deregulated in up to 70% of human cancers, can be used as a robust proteomic signature for cancer. Herein, we developed a rapid, highly specific, and sensitive surface-enhanced Raman scattering (SERS) assay for the quantification of c-MYC in real blood samples. The sensing scheme relies on the use of specifically designed hybrid plasmonic materials and their bioderivatization with a selective peptidic receptor modified with a SERS transducer. Peptide/c-MYC recognition events translate into measurable alterations of the SERS spectra associated with a molecular reorientation of the transducer, in agreement with the surface selection rules. The efficiency of the sensor is demonstrated in cellular lines, healthy donors and a cancer patient
dc.description.sponsorshipThis work was funded by Marie Curie Actions (FP7/2007-2013, TECNIOspring no. 600388 and PrioSERS FP72014-623527), the European Research Council (Advanced Grant No. 340055), the Spanish MINECO (CTQ2014-59808R, SAF2013-41943-R, CTQ2015-70698-R, CTQ2013-49317-EXP and the orfeo-cinqa network), the Generalitat of Catalonia (2014-SGR-480, AGAUR 2014 052 and AGAUR 2014 054), the Xunta de Galicia (GRC2013-041), and Medcom Advance S.A.
dc.publisherAmerican Chemical Society
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2013-49317/ES/EXPLORACION DE TERAPIAS ANTITUMORALES ALTERNATIVAS DIRIGIDAS A LAS MITOCONDRIAS
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-41943-R/ES/HERRAMIENTAS SINTETICAS EN QUIMICA BIOLOGICA. NUEVAS ESTRATEGIAS MOLECULARES PARA EL TRATAMIENTO Y DIAGNOSTICO DE CANCERES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2015-70698-R/ES/SISTEMAS SUPRAMOLECULARES PARA RECONOCIMIENTO BIOMOLECULAR: HELICATOS PEPTIDICOS Y RECEPTORES OLIGOMERICOS AUTOENSAMBLADOS
dc.rights© American Chemical Society
dc.subjectBlood-based biomarkers
dc.subject.classificationMaterias::Investigación::23 Química
dc.titleSurface-enhanced raman scattering surface selection rules for the proteomic liquid biopsy in real samples: Efficient detection of the oncoprotein c-MYC
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica

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