Tuning the properties of penetrating peptides by oxime conjugation
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| Title: | Tuning the properties of penetrating peptides by oxime conjugation |
| Author: | Pazo Pascual, Marta Fernández Caro, Héctor Priegue Caamaño, Juan Manuel Lostalé Seijo, Irene Montenegro García, Javier |
| Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Subject: | Peptide chemistry | Penetrating peptides | Supramolecular chemistry | Membrane transport | Solid-phase peptide synthesis | |
| Date of Issue: | 2017-01-25 |
| Publisher: | Georg Thieme Verlag |
| Citation: | Montenegro, Javier, Pazo, Marta, Fernández-Caro, Héctor, Priegue, Juan and Lostalé-Seijo, Irene, 2017, Tuning the Properties of Penetrating Peptides by Oxime Conjugation. Synlett. 2017. DOI 10.1055/s-0036-1588689. Thieme Publishing Group |
| Abstract: | We here describe the application of oxime bond formation between a peptide scaffold and different aldehydes to modify the transporting capabilities of penetrating peptides. We show that bonds such as oximes offer a great synthetic advantage for the modification of the properties of model penetrating peptides. We believe that this approach will allow the development of improved intracellular delivery vehicles |
| Publisher version: | http://dx.doi.org/10.1055/s-0036-1588689 |
| URI: | http://hdl.handle.net/10347/15141 |
| DOI: | 10.1055/s-0036-1588689 |
| ISSN: | 0936-5214 |
| E-ISSN: | 1437-2096 |
| Rights: | Atribución-NoComercial-SinDerivadas 3.0 España |
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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España