Tuning the properties of penetrating peptides by oxime conjugation

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http://hdl.handle.net/10347/15141

Title:	Tuning the properties of penetrating peptides by oxime conjugation
Author:	Pazo Pascual, Marta Fernández Caro, Héctor Priegue Caamaño, Juan Manuel Lostalé Seijo, Irene Montenegro García, Javier
Affiliation:	Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica
Subject:	Peptide chemistry \| Penetrating peptides \| Supramolecular chemistry \| Membrane transport \| Solid-phase peptide synthesis \|
Date of Issue:	2017-01-25
Publisher:	Georg Thieme Verlag
Citation:	Montenegro, Javier, Pazo, Marta, Fernández-Caro, Héctor, Priegue, Juan and Lostalé-Seijo, Irene, 2017, Tuning the Properties of Penetrating Peptides by Oxime Conjugation. Synlett. 2017. DOI 10.1055/s-0036-1588689. Thieme Publishing Group
Abstract:	We here describe the application of oxime bond formation between a peptide scaffold and different aldehydes to modify the transporting capabilities of penetrating peptides. We show that bonds such as oximes offer a great synthetic advantage for the modification of the properties of model penetrating peptides. We believe that this approach will allow the development of improved intracellular delivery vehicles
Publisher version:	http://dx.doi.org/10.1055/s-0036-1588689
URI:	http://hdl.handle.net/10347/15141
DOI:	10.1055/s-0036-1588689
ISSN:	0936-5214
E-ISSN:	1437-2096
Rights:	Atribución-NoComercial-SinDerivadas 3.0 España

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