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dc.contributor.authorCendón Mariño, Borja
dc.contributor.authorCasanova González, Noelia
dc.contributor.authorComanescu, Cezar
dc.contributor.authorGarcía Fandiño, Rebeca
dc.contributor.authorSeoane Fernández, Andrés
dc.contributor.authorGulías Costa, Moisés
dc.contributor.authorMascareñas Cid, José Luis
dc.identifier.citationCendón, B., Casanova, N., Comanescu, C., Garcí­a-Fandiño, R., Seoane, A., Gulías, M. & Mascareñas, J.L. 2017, "Palladium-Catalyzed Formal (5 + 2) Annulation between ortho-Alkenylanilides and Allenes", Organic letters, vol. 19, no. 7, pp. 1674-1677
dc.descriptionThis is the peer reviewed version of the following article: Borja Cendón, Noelia Casanova, Cezar Comanescu, Rebeca García-Fandiño, Andrés Seoane, Moisés Gulías* and José L. Mascareñas*, Palladium-Catalyzed Formal (5+2) annulation between ortho-Alkenylanilides and Allenes. Org. Lett. 2017, 19, 1674-1677 [DOI: ]. This article may be used for non commercial purposes in accordance with American Chemical Society Terms and Conditions for self-archiving
dc.description.abstract2-Alkenyltriflylanilides react with allenes upon treatment with catalytic amounts of Pd(OAc)2 and Cu(II) to give highly valuable 2,3-dihydro-1H-benzo[b]azepines, in good yields, and with very high regio- and diastereoselectivities. Density functional theory (DFT) calculations suggest that the C–H activation of the alkenylanilide involves a classical concerted metalation–deprotonation (CMD) mechanism
dc.description.sponsorshipThis work has received financial support from Spanish grants (SAF2013-41943-R, SAF2016-76689-R, CTQ2015-74621-JIN and CTQ2016-77047-P), the Consellería de Cultura, Educación e Ordenación Universitaria (GRC2013-041, 2015-CP082 and Centro Singular de Investigación de Galicia accreditation 2016-2019, ED431G/09), the European Regional Development Fund (ERDF), and the European Research Council (Advanced Grant No. 340055). R. G.-F. thanks a FCT scholarship from Portugal. The orfeo-cinqa network CTQ2014-51912-REDC is kindly acknowledged. All calculations were carried out at Centro de Supercomputación de Galicia (CESGA)
dc.publisherAmerican Chemical Society
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-76689-R/ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2015-74621-JIN/ES/DISEÑO DE BIOCIDAS INNOVADORES A PARTIR DE LA ELUCIDACION DEL MECANISMO DE OLIGOMEROS CON PROPIEDADES ANTIMICROBIANAS
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-41943-R/ES/HERRAMIENTAS SINTETICAS EN QUIMICA BIOLOGICA. NUEVAS ESTRATEGIAS MOLECULARES PARA EL TRATAMIENTO Y DIAGNOSTICO DE CANCERES
dc.rights© 2017 American Chemical Society
dc.subjectOrtho- alkenylanilides
dc.subject.classificationMaterias::Investigación::23 Química::2302 Bioquímica
dc.titlePalladium-Catalyzed Formal (5 + 2) Annulation between ortho-Alkenylanilides and Allenes
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica

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