| dc.contributor.author | Varela Sandá, Iván |
| dc.contributor.author | Faustino, Hélio |
| dc.contributor.author | Díez Martín, Elena |
| dc.contributor.author | Iglesias Sigüenza, Francisco Javier |
| dc.contributor.author | Grande-Carmona, Francisca |
| dc.contributor.author | Fernández, Rosario |
| dc.contributor.author | Lassaletta, José M. |
| dc.contributor.author | Mascareñas Cid, José Luis |
| dc.contributor.author | López García, Fernando |
| dc.date.accessioned | 2017-05-31T18:05:50Z |
| dc.date.available | 2018-02-22T02:00:10Z |
| dc.date.issued | 2017-02-22 |
| dc.identifier.citation | Varela, Iván, Faustino, Hélio, Díez, Elena, Iglesias-Sigüenza, Javier, Grande-Carmona, Francisca, Fernández, Rosario, Lassaletta, José M., Mascareñas, José L. and López, Fernando, 2017, Gold(I)-Catalyzed Enantioselective [2+2+2] Cycloadditions: An Expedient Entry to Enantioenriched Tetrahydropyran Scaffolds. ACS Catalysis. 2017. Vol. 7, no. 4, p. 2397-2402. DOI 10.1021/acscatal.6b03651. American Chemical Society (ACS) |
| dc.identifier.uri | http://hdl.handle.net/10347/15445 |
| dc.description | This is the peer reviewed version of the following article: Iván Varela, Hélio Faustino, Elena Díez, Javier Iglesias-Sigüenza, Francisca Grande-Carmona, Rosario Fernández, José M. Lassaletta, José L. Mascareñas* and Fernando López*, Gold (I)-Catalyzed Enantioselective [2+2+2] Cycloadditions: An Expedient Entry to Enantioenriched Tetrahydropyran Scaffolds. ACS Catal. 2017, 7, 2397-2402 [DOI: 10.1021/acscatal.6b03651]. This article may be used for non-commercial purposes in accordance with American Chemical Society Terms and Conditions for self-archiving |
| dc.description.abstract | A straightforward and atom-economical enantioselective approach to highly substituted tetrahydropyrans is reported. The process, which consists of an intermolecular gold-catalyzed [2+2+2] cycloaddition between allenamides, alkenes, and aldehydes, is efficiently catalyzed by both phosphoramidite- and chiral N-heterocyclic carbene-gold catalysts, occurs with complete chemoselectivity and regioselectivity, moderate diastereoselectivity, and moderate to very good enantioselectivities |
| dc.description.sponsorship | This work was supported by the Spanish MINECO (grant:SAF2013-41943-R, CTQ2013-48164-C2-1-P and -2-P), the Consellería de Cultura, Educación e Ordenación Universitaria (GRC2013-041, 2015-CP082 and Centro Singular de Investigación de Galicia accreditation 2016-2019, ED431G/09) the European Regional Development Fund (ERDF), the European Research Council (Adv. Grant No. 340055), and the Junta de Andalucía (Grant 2012/FQM 1078). We also thank the Orfeo-Cinqa network |
| dc.language.iso | eng |
| dc.publisher | American Chemical Society |
| dc.relation | info:eu-repo/grantAgreement/EC/FP7/340055 |
| dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-41943-R/ES/HERRAMIENTAS SINTETICAS EN QUIMICA BIOLOGICA. NUEVAS ESTRATEGIAS MOLECULARES PARA EL TRATAMIENTO Y DIAGNOSTICO DE CANCERES |
| dc.rights | © 2017 American Chemical Society |
| dc.subject | Allenamide |
| dc.subject | Cycloaddition |
| dc.subject | Enantioselective synthesis |
| dc.subject | Gold catalysis |
| dc.subject | N-heterocyclic carbenes |
| dc.subject | Tetrahydropyrans |
| dc.subject.classification | Materias::Investigación::23 Química::2302 Bioquímica |
| dc.title | Gold(I)-Catalyzed Enantioselective [2+2+2] Cycloadditions: An Expedient Entry to Enantioenriched Tetrahydropyran Scaffolds |
| dc.type | info:eu-repo/semantics/article |
| dc.identifier.DOI | 10.1021/acscatal.6b03651 |
| dc.relation.publisherversion | http://dx.doi.org/10.1021/acscatal.6b03651 |
| dc.type.version | info:eu-repo/semantics/acceptedVersion |
| dc.identifier.e-issn | 2155-5435 |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess |
| dc.contributor.affiliation | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares |
| dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| dc.description.peerreviewed | SI |
