Now showing items 1-20 of 162

    • A Critical Reassessment of the Role of Mitochondria in Tumorigenesis 

      Salas Ellacuriaga, Antonio; Yao, Yong-Gang; Macaulay, Vincent; Vega Gliemmo, Ana Paula; Carracedo Álvarez, Ángel María; Bandelt, Hans-Jürgen (Plos, 2005)
      Background Mitochondrial DNA (mtDNA) is being analyzed by an increasing number of laboratories in order to investigate its potential role as an active marker of tumorigenesis in various types of cancer. Here we question ...
    • Contenido de mercurio en conservas de mejillones, berberechos y navajas comercializados en Galicia (España) 

      Fernández García, M. A.; Alonso Díaz, Julián; Loira Torres, Laura; Melgar Riol, María Julia (Taylor & Francis, 2007)
      Molluscs accumulate heavy metals and impose health hazard to consumers. Mercury is considered as a metal not essential and very toxic. Concentrations of mercury were determined for tinned mussels, common cockle and razors ...
    • Distilling Artificial Recombinants from Large Sets of Complete mtDNA Genomes 

      Kong, Qing-Peng; Salas Ellacuriaga, Antonio; Sun, Chang; Fuku, Noriyuki; Tanaka, Masashi; Zhong, Li; Wang, Cheng-Ye; Yao, Yong-Gang; Bandelt, Hans-Jürgen (PLOS, 2008)
      Background: Large-scale genome sequencing poses enormous problems to the logistics of laboratory work and data handling. When numerous fragments of different genomes are PCR amplified and sequenced in a laboratory, there ...
    • Retinoblastoma Loss Modulates DNA Damage Response Favoring Tumor Progression 

      Seoane, Marcos; Iglesias, Pablo; González Martínez, Teresa; Domínguez Puente, Fernando Ignacio; Fraga Rodríguez, Máximo Francisco; Aliste Santos, Carlos; Forteza Vila, Jerónimo; Costoya Puente, José Antonio (PLOS, 2008)
      Senescence is one of the main barriers against tumor progression. Oncogenic signals in primary cells result in oncogeneinduced senescence (OIS), crucial for protection against cancer development. It has been described in ...
    • Estimating Haplotype Frequency and Coverage of Databases 

      Egeland, Thore; Salas Ellacuriaga, Antonio (Plos, 2008)
      A variety of forensic, population, and disease studies are based on haploid DNA (e.g. mitochondrial DNA or Y-chromosome data). For any set of genetic markers databases of conventional size will normally contain only a ...
    • SPSmart: adapting population based SNP genotype databases for fast and comprehensive web access 

      Amigo Lechuga, Jorge; Salas Ellacuriaga, Antonio; Phillips, Christopher Paul; Carracedo Álvarez, Ángel María (BMC, 2008)
      Background: In the last five years large online resources of human variability have appeared, notably HapMap, Perlegen and the CEPH foundation. These databases of genotypes with population information act as catalogues ...
    • Genomic degradation of a young Y chromosome in Drosophila miranda 

      Bachtrog, Doris; Hom, Emily; Wong, Karen M.; Maside Rodríguez, Xulio; Jong, Pieter de (BMC, 2008)
      Background: Y chromosomes are derived from ordinary autosomes and degenerate because of a lack of recombination. Well-studied Y chromosomes only have few of their original genes left and contain little information about ...
    • RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population 

      Freitas, Ana I.; Mendonça, Isabel; Brión Martínez, María José; Sequeira, Miguel M.; Reis, Roberto P.; Carracedo Álvarez, Ángel María; Brehm, António (BMC, 2008)
      Background: Several polymorphisms within the renin-angiotensin system cluster of genes have been associated with the advent of coronary artery disease (CAD) or related pathologies. We investigated the distribution of 5 ...
    • Minisequencing mitochondrial DNA pathogenic mutations 

      Álvarez Iglesias, Vanesa; Barros Angueira, Francisco; Carracedo Álvarez, Ángel María; Salas Ellacuriaga, Antonio (BMC, 2008)
      Background: There are a number of well-known mutations responsible of common mitochondrial DNA (mtDNA) diseases. In order to overcome technical problems related to the analysis of complete mtDNA genomes, a variety of ...
    • Genetic origin, admixture, and asymmetry in maternal and paternal human lineages in Cuba 

      Mendizábal, Isabel; Sandoval, Karla; Berniell Lee, Gemma; Calafell, Francesc; Salas Ellacuriaga, Antonio; Martínez Fuentes, Antonio; Comas, David (BMC, 2008)
      Background: Before the arrival of Europeans to Cuba, the island was inhabited by two Native American groups, the Tainos and the Ciboneys. Most of the present archaeological, linguistic and ancient DNA evidence indicates ...
    • The Phylogeny of the Four Pan-American MtDNA Haplogroups: Implications for Evolutionary and Disease Studies 

      Achilli, Alessandro; Perego, Ugo A.; Bravi, Claudio M.; Coble, Michael D.; Kong, Qing-Peng; Woodward, Scott R.; Salas Ellacuriaga, Antonio; Torroni, Antonio; Bandelt, Hans-Jürgen (Plos, 2008)
      Only a limited number of complete mitochondrial genome sequences belonging to Native American haplogroups were available until recently, which left America as the continent with the least amount of information about ...
    • Timing and deciphering mitochondrial DNA macro-haplogroup R0 variability in Central Europe and Middle East 

      Brandstätter, Anita; Zimmermann, Bettina; Wagner, Janine; Göbel, Tanja; Röck, Alexander W.; Salas Ellacuriaga, Antonio; Carracedo Álvarez, Ángel María; Parson, Walther (BMC, 2008)
      Background: Nearly half of the West Eurasian assemblage of human mitochondrial DNA (mtDNA) is fractioned into numerous sub-lineages of the predominant haplogroup (hg) R0. Several hypotheses have been proposed on the ...
    • New Population and Phylogenetic Features of the Internal Variation within Mitochondrial DNA Macro-Haplogroup R0 

      Álvarez Iglesias, Vanesa; Mosquera Miguel, Ana; Cerezo Fernández, María; Quintáns Castro, Beatriz; Zarrabeitia, María T.; Cuscó, Ivon; Lareu Huidobro, María Victoria; García García, Óscar; Pérez Jurado, Luís Alberto; Carracedo Álvarez, Ángel María; Salas Ellacuriaga, Antonio (PLOS, 2009)
      Background: R0 embraces the most common mitochondrial DNA (mtDNA) lineage in West Eurasia, namely, haplogroup H (,40%). R0 sub-lineages are badly defined in the control region and therefore, the analysis of diagnostic ...
    • Acumulación de selenio en setas silvestres comestibles: captación y toxicidad Selenium accumulation in wild edible mushrooms: uptake and toxicity 

      Melgar Riol, María Julia; Alonso Díaz, Julián; García Fernández, María Ángeles (Taylor & Francis, 2009)
      Los hongos acumulan selenio, metal considerado nutricionalmente oligoelemento, pero nocivo para la salud del consumidor en dosis excesivas. Se estudió el contenido de selenio en setas silvestres comestibles, teniendo en ...
    • Investigating the Role of Mitochondrial Haplogroups in Genetic Predisposition to Meningococcal Disease 

      Salas Ellacuriaga, Antonio; Fachal Vilar, Laura; Marcos Alonso, Sonia; Vega Gliemmo, Ana Paula; Martinón Torres, Federico; Grupo de investigación ESIGEM (Estudio Sobre la Influencia Genética en la Enfermedad Meningocócica) (PLOS, 2009)
      Background and Aims: Meningococcal disease remains one of the most important infectious causes of death in industrialized countries. The highly diverse clinical presentation and prognosis of Neisseria meningitidis infections ...
    • Ancestry Analysis in the 11-M Madrid Bomb Attack Investigation 

      Phillips, Christopher Paul; Prieto, Lourdes; Fondevila Álvarez, Manuel; Salas Ellacuriaga, Antonio; Gómez Tato, Antonio; Álvarez Dios, José Antonio; Alonso, Antonio; Blanco Verea, Alejandro José; Brión Martínez, María José; Montesino, Marta; Carracedo Álvarez, Ángel María; Lareu Huidobro, María Victoria (PLOS, 2009)
      The 11-M Madrid commuter train bombings of 2004 constituted the second biggest terrorist attack to occur in Europe after Lockerbie, while the subsequent investigation became the most complex and wide-ranging forensic case ...
    • Mitochondrial Echoes of First Settlement and Genetic Continuity in El Salvador 

      Salas Ellacuriaga, Antonio; Lovo Gómez, José; Álvarez Iglesias, Vanesa; Cerezo Fernández, María; Lareu Huidobro, María Victoria; Macaulay, Vincent; Richards, Martin B.; Carracedo Álvarez, Ángel María (Plos, 2009)
      Background: From Paleo-Indian times to recent historical episodes, the Mesoamerican isthmus played an important role in the distribution and patterns of variability all around the double American continent. However, the ...
    • High Mitochondrial DNA Stability in B-Cell Chronic Lymphocytic Leukemia 

      Cerezo Fernández, María; Bandelt, Hans-Jürgen; Martín Guerrero, Idoia; Ardanaz, Maite; Vega Gliemmo, Ana Paula; Carracedo Álvarez, Ángel María; García Orad, África; Salas Ellacuriaga, Antonio (PLOS, 2009)
      Background: Chronic Lymphocytic Leukemia (CLL) leads to progressive accumulation of lymphocytes in the blood, bone marrow, and lymphatic tissues. Previous findings have suggested that the mtDNA could play an important ...
    • Molecular analysis of the APC and MUTYH genes in Galician and Catalonian FAP families: a different spectrum of mutations? 

      Gómez Fernández, Nuria; Castellví Bel, Sergi; Fernández Rozadilla, Ceres; Balaguer, Francesc; Muñoz, Jenifer; Madrigal, Irene; Milà, Montserrat; Graña Suárez, Begoña; Vega Gliemmo, Ana Paula; Castells, Antoni; Carracedo Álvarez, Ángel María; Ruiz Ponte, Clara (BMC, 2009)
      Background: Familial adenomatous polyposis (FAP) is an autosomal dominant-inherited colorectal cancer syndrome, caused by germline mutations in the APC gene. Recently, biallelic mutations in MUTYH have also been identified ...
    • Contamination and sample mix-up can best explain some patterns of mtDNA instabilities in buccal cells and oral squamous cell carcinoma 

      Bandelt, Hans-Jürgen; Salas Ellacuriaga, Antonio (BMC, 2009)
      The study of somatic DNA instabilities constitutes a debatable topic because different causes can lead to seeming DNA alteration patterns between different cells or tissues from the same individual. Carcinogenesis or the ...





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