Now showing items 1-20 of 162

    • A 2-transcript host cell signature distinguishes viral from bacterial diarrhea and it is influenced by the severity of symptoms 

      Barral Arca, Ruth; Pardo Seco, Jacobo José; Martinón Torres, Federico; Salas Ellacuriaga, Antonio (Nature Publishing Group, 2018)
      Recently, a biomarker signature consisting of 2-transcript host RNAs was proposed for discriminating bacterial from viral infections in febrile children. We evaluated the performance of this signature in a different disease ...
    • Acumulación de selenio en setas silvestres comestibles: captación y toxicidad Selenium accumulation in wild edible mushrooms: uptake and toxicity 

      Melgar Riol, María Julia; Alonso Díaz, Julián; García Fernández, María Ángeles (Taylor & Francis, 2009)
      Los hongos acumulan selenio, metal considerado nutricionalmente oligoelemento, pero nocivo para la salud del consumidor en dosis excesivas. Se estudió el contenido de selenio en setas silvestres comestibles, teniendo en ...
    • affy2sv: an R package to pre-process Affymetrix CytoScan HD and 750K arrays for SNP, CNV, inversion and mosaicism calling 

      Hernández Ferrer, Carles; Quintela García, Inés; Danielski, Katharina; Carracedo Álvarez, Ángel María; Pérez Jurado, Luís Alberto; González, Juan R. (BMC, 2015)
      Background The well-known Genome-Wide Association Studies (GWAS) had led to many scientific discoveries using SNP data. Even so, they were not able to explain the full heritability of complex diseases. Now, other structural ...
    • Alterations of gray and white matter morphology in obsessive compulsive disorder 

      Gonçalves, Óscar F.; Sousa, Sonia; Carvalho, Sandra; Leite, Jorge; Ganho, Ana; Fernandes-Gonçalves, Ana; Pocinho, Fernando; Carracedo Álvarez, Ángel María; Sampaio, Adriana (Colegio Oficial de Psicólogos del Principado, 2017)
      While the ethio-pathogenesis of Obsessive-Compulsive disorder (OCD) remains unknown, there is increased evidence of widespread structural alterations in both white and gray matter in OCD patients ...
    • Analysis of expression of the PD-1/PD-L1 immune checkpoint system and its prognostic impact in gastroenteropancreatic neuroendocrine tumors 

      Sampedro Núñez, Miguel; Serrano Somavilla, Ana; Adrados, Magdalena; Cameselle Teijeiro, José Manuel; Blanco Carrera, Concepción; Cabezas Agrícola, José Manuel; Martínez Hernández, Rebeca; Martín Pérez, Elena; Muñoz de Nova, José Luis; Díaz, José Ángel; García Centeno, Rogelio; Caneiro Gómez, Javier; Abdulkader, Ihab; González Amaro, Roberto; Marazuela, Mónica (Nature Publishing Group, 2018)
      The immune checkpoint based therapy targeting the programmed death-1 (PD-1) receptor and its PD-L1 ligand has recently been approved for the therapy of different malignant conditions, but not yet for gastroenteropancreatic ...
    • Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ 

      Solé Morata, Neus; Villaescusa, Patricia; García Fernández, Carla; Font Porterias, Neus; Illescas, María José; Valverde, Laura; Tassi, Francesca; Ghirotto, Silvia; Férec, Claude; Rouault, Karen; Jiménez Moreno, Susana; Martínez Jarreta, Begoña; Pinheiro, Maria Fátima; Zarrabeitia, María T.; Carracedo Álvarez, Ángel María; Pancorbo, Marian M. de; Calafell, Francesc (Nature Publishing Group, 2017)
      Haplogroup R1b-M269 comprises most Western European Y chromosomes; of its main branches, R1b-DF27 is by far the least known, and it appears to be highly prevalent only in Iberia. We have genotyped 1072 R1b-DF27 chromosomes ...
    • Ancestry Analysis in the 11-M Madrid Bomb Attack Investigation 

      Phillips, Christopher Paul; Prieto, Lourdes; Fondevila Álvarez, Manuel; Salas Ellacuriaga, Antonio; Gómez Tato, Antonio; Álvarez Dios, José Antonio; Alonso, Antonio; Blanco Verea, Alejandro José; Brión Martínez, María José; Montesino, Marta; Carracedo Álvarez, Ángel María; Lareu Huidobro, María Victoria (PLOS, 2009)
      The 11-M Madrid commuter train bombings of 2004 constituted the second biggest terrorist attack to occur in Europe after Lockerbie, while the subsequent investigation became the most complex and wide-ranging forensic case ...
    • ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents 

      Barja Fernández, Silvia; Folgueira Cobos, Cintia; Castelao Taboada, Cecilia; Pena León, Verónica; González Saenz, Patricia; Vázquez Cobela, Rocío; Aguilera, Concepción M.; Gil Campos, Mercedes; Bueno Lozano, Gloria; Gil, Ángel; Moreno, Luis A.; Ruiz Piñón, Manuel; García Palacios, María; Casanueva Freijo, Felipe; Diéguez González, Carlos; Nogueiras Pozo, Rubén; Leis Trabazo, María Rosaura; Seoane Camino, Luisa María (MDPI, 2019)
      Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its ...
    • Antibiotic Dispensation without a Prescription Worldwide: A Systematic Review 

      Batista, Ana Daniela; Rodrigues, Daniela A.; Figueiras Guzmán, Adolfo; Zapata Cachafeiro, Maruxa; Roque, Fátima; Herdeiro, Maria Teresa Ferreira (MDPI, 2020)
      Antibiotic resistance still remains a major global public health problem and the dispensing of antibiotics without a prescription at community pharmacies is an important driver of this. MEDLINE, Pubmed and EMBASE databases ...
    • Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status 

      Rupérez, Azahara I.; Mesa, María D.; Anguita Ruiz, Augusto; González Gil, Esther M.; Vázquez Cobela, Rocío; Moreno, Luis A.; Gil, Ángel; Gil Campos, Mercedes; Leis Trabazo, María Rosaura; Bueno Lozano, Gloria; Aguilera, Concepción M. (MDPI, 2020)
      Oxidative stress could help explain the relationship between childhood obesity and a metabolically unhealthy (MU) status. Moreover, puberty could also influence this relationship, since it entails physiological cardiometabolic ...
    • Antivirals for influenza-like illness? a randomised controlled trial of clinical and cost effectiveness in primary carE (ALIC4 E): the ALIC4 E protocol 

      Bongard, Emily; Van der Velden, Alike W.; Cook, Johanna; Saville, Ben; Beutels, Philippe; Aabenhus, Rune Munck; Brugman, Curt; Chlabicz, Slawomir; Coenen, Samuel; Colliers, Annelies; Davies, Melanie; De Paor, Muireann; De Sutter, An; Francis, Nick A.; Glinz, Dominik; Godycki-ćwirko, Maciek; Goossens, Hermann; Holmes, Jane; Ieven, Margareta; De Jong, Menno; Lindbaek, Morten; Little, Paul; Martinón Torres, Federico; Moragas, Ana; Pauer, József; Pfeiferová, Markéta; Radzeviciene-Jurgute, Ruta; Sundvall, Pär-Daniel; Torres, Antoni; Touboul, Pia; Varthalis, Dionyssios; Verheij, Theo; Butler, Christopher C. (BMJ, 2018)
      Effective management of seasonal and pandemic influenza is a high priority internationally. Guidelines in many countries recommend antiviral treatment for older people and individuals with comorbidity at increased risk of ...
    • Arrival of Paleo-Indians to the Southern Cone of South America: new clues from mitogenomes 

      Saint Pierre, Michelle de; Gandini, Francesca; Perego, Ugo A.; Bodner, Martin; Gómez Carballa, Alberto; Corach, Daniel; Angerhofer, Norman; Woodward, Scott R.; Semino, Ornella; Salas Ellacuriaga, Antonio; Parson, Walther; Moraga, Mauricio; Achilli, Alessandro; Torroni, Antonio; Olivieri, Anna (PLOS, 2012)
      With analyses of entire mitogenomes, studies of Native American mitochondrial DNA (mtDNA) variation have entered the final phase of phylogenetic refinement: the dissection of the founding haplogroups into clades that arose ...
    • Bacteremia in Children Hospitalized with Respiratory Syncytial Virus Infection 

      Cebey López, Miriam; Pardo Seco, Jacobo José; Gómez Carballa, Alberto; Martinón Torres, Nazareth; Martinón-Torres, José María; Justicia Grande, Antonio; Rivero Calle, Irene; Pinnock, Ellie; Salas Ellacuriaga, Antonio; Fink, Colin; Martinón Torres, Federico; GENDRES network (PLOS, 2016-02-12)
      Background The risk of bacteremia is considered low in children with acute bronchiolitis. However the rate of occult bacteremia in infants with RSV infection is not well established. The aim was to determine the actual ...
    • BDNF genetic variants and methylation: effects on cognition in major depressive disorder 

      Ferrer, Alex; Labad, Javier; Salvat-Pujol, Neus; Barrachina, Marta; Costas Costas, Javier; Urretavizcaya, Mikel; Arriba-Arnau, Aida de; Crespo, José M.; Soriano-Mas, Carles; Carracedo Álvarez, Ángel María; Menchón, José M.; Soria, Virginia (Nature Publishing Group, 2019)
      Brain-derived neurotrophic factor (BDNF) gene regulation has been linked to the pathophysiology of major depressive disorder (MDD). MDD patients show cognitive deficits, and altered BDNF regulation has a relevant role in ...
    • Beyond the CSI effect the keys to good forensicgenetics communication 

      Carracedo Álvarez, Ángel María; Prieto Solla, Lourdes (Universitat de València, 2019)
      Forensic genetics brings together all the genetic knowledge required to solve specific legal problems. In recent decades new techniques have shown the potential of DNA as a profiling system. These advances have arrived ...
    • Building a custom large-scale panel of novel microhaplotypes for forensic identification using MiSeq and Ion S5 massively parallel sequencing systems 

      Puente Vila, María del Carmen de la; Phillips, Christopher Paul; Xavier, Catarina; Amigo Lechuga, Jorge; Carracedo Álvarez, Ángel María; Parson, Walther; Lareu Huidobro, María Victoria (Elsevier, 2020)
      A large number of new microhaplotype loci were identified in the human genome by applying a directed search with selection criteria emphasizing short haplotype length (<120 nucleotides) and maximum levels of polymorphism ...
    • Changes in Physical Activity Patterns from Childhood to Adolescence: Genobox Longitudinal Study 

      Llorente Cantarero, Francisco Jesús; Aguilar Gómez, Francisco Javier; Anguita Ruiz, Augusto; Rupérez, Azahara I.; Vázquez Cobela, Rocío; Flores Rojas, Khaterine; Aguilera, Concepción M.; González Gil, Esther M.; Gil Campos, Mercedes; Bueno Lozano, Gloria; Leis Trabazo, María Rosaura (MDPI, 2020)
      Longitudinal changes of physical activity (PA) from childhood into adolescence have not been accurately described yet for the Spanish population. The aim of this study is to evaluate the changes of PA, assessed by accelerometry ...
    • Characterization of New Proteomic Biomarker Candidates in Mucopolysaccharidosis Type IVA 

      Álvarez González, José Víctor; Bravo López, Susana Belén; Chantada Vázquez, María del Pilar; Colón Mejeras, Cristóbal; Castro López, María José de; Morales, Montserrat; Vitoria, Isidro; Tomatsu, Shunji; Otero Espinar, Francisco Javier; Couce Pico, María de la Luz (MDPI, 2021)
      Mucopolysaccharidosis type IVA (MPS IVA) is a lysosomal storage disease caused by mutations in the N-acetylgalactosamine-6-sulfatase (GALNS) gene. Skeletal dysplasia and the related clinical features of MPS IVA are caused ...
    • Clinical manifestations in female carriers of mucopolysaccharidosis type II: a spanish cross-sectional study 

      Guillén Navarro, Encarnación; Domingo Jiménez, María Rosario; Alcalde Martín, Carlos; Cancho Candela, Ramón; Couce Pico, María de la Luz; Galán Gómez, Enrique; Alonso Luengo, Olga (BioMed Central, 2013)
      Background: Mucopolysaccharidosis type II (MPS II) is an inherited X-linked disease associated with a deficiency in the enzyme iduronate 2-sulfatase due to iduronate 2-sulfatase gene (IDS) mutations. Recent studies in MPS ...
    • Clinical Utility of LCT Genotyping in Children with Suspected Functional Gastrointestinal Disorder 

      Couce Pico, María de la Luz; Sánchez Pintos, Paula; González Vioque, Emiliano; Leis Trabazo, María Rosaura (MDPI, 2020)
      Genetic testing is a good predictor of lactase persistence (LP) in specific populations but its clinical utility in children is less clear. We assessed the role of lactose malabsorption in functional gastrointestinal ...





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