Membrane-disrupting iridium(III) oligocationic organometallopeptides
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| Title: | Membrane-disrupting iridium(III) oligocationic organometallopeptides |
| Author: | Salvadó, Iria Gamba, Ilaria Montenegro, Javier Martínez Costas, José Manuel Brea, José Manuel Loza, María Isabel Vázquez López, Miguel Vázquez Sentís, Marco Eugenio |
| Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Inorgánica Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Date of Issue: | 2016-08-19 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Salvadó, I, Gamba, I, Montenegro J, Martínez-Costas J, Brea JM, Loza MI, Vázquez López M, Vázquez M.E. Membrane-disrupting iridium(III) oligocationic organometallopeptides. Chem. Commun., 2016,52, 11008-11011. DOI: 10.1039/C6CC05537K |
| Abstract: | A series of oligoarginine peptide derivatives containing cyclometallated iridium(III) units display remarkable cytotoxicity, comparable to that of cisplatin. In vitro studies with unilamellar vesicles support a membrane-disrupting mechanism of action |
| Description: | NOTICE: This is the peer reviewed version of the following article: Salvadó, I, Gamba, I, Montenegro J, Martínez-Costas J, Brea JM, Loza MI, Vázquez López M, Vázquez M.E. Membrane-disrupting iridium(III) oligocationic organometallopeptides. Chem. Commun., 2016,52, 11008-11011. DOI: 10.1039/C6CC05537K. This article may be used for non-commercial purposes in accordance with RSC Terms and Conditions for self-archiving |
| Publisher version: | http://dx.doi.org/10.1039/C6CC05537K |
| URI: | http://hdl.handle.net/10347/15772 |
| DOI: | 10.1039/C6CC05537K |
| ISSN: | 1359-7345 |
| E-ISSN: | 1364-548X |
| Rights: | © The Royal Society of Chemistry 2016 |
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