Now showing items 1-12 of 12

    • Canonical DNA minor groove insertion of bisbenzamidine–Ru(ii) complexes with chiral selectivity 

      Sánchez, Mateo I.; Rama, Gustavo; Calo Lapido, Renata; Ucar, Kübra; Lincoln, Per; Vázquez López, Miguel; Melle-Franco, Manuel; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (Royal Society of Chemistry, 2019)
      We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor ...
    • A chemosensor for dihydrogenphosphate based on an oxoazamacrocycle possessing three thiourea arms 

      Aldrey, Anxela; Macías, Alejandro; Bastida, Rufina; Zaragoza, Guillermo; Rama, Gustavo; Vázquez López, Miguel (Royal Society of Chemistry, 2012)
      We report a new H-bond macrocyclic chromogenic chemosensor in organic media, H3L, which displayed drastic changes in its UV–vis spectra revealing selectivity for dihydrogenphosphate over other inorganic anions, such as ...
    • Copper(II) Complexes of Cyclams Containing Nitrophenyl Substituents: Push–Pull Behavior and Scorpionate Coordination of the Nitro Group 

      Boiocchi, Massimo; Ciarrocchi, Carlo; Fabbrizzi, Luigi; Licchelli, Maurizio; Mangano, Carlo; Poggi, Antonio; Vázquez López, Miguel (American Chemical Society, 2015)
      The three nitrophenyl–cyclam derivatives (nitrocyclams): 1-(4-nitrophenyl)-1,4,8,11-tetraazacyclotetradecane (2), 1-(2-nitrophenyl)-1,4,8,11-tetraazacyclotetradecane (3), and 1-(2,4-dinitrophenyl)-1,4,8,11-tetraazacyclotetradecane ...
    • Custom‐Fit Ruthenium(II) Metallopeptides: A New Twist to DNA Binding With Coordination Compounds 

      Gamba, Ilaria; Salvadó, Iria; Rama, Gustavo; Bertazzon, Miriam; Sánchez López, Mateo Isidro; Sánchez-Pedregal, Víctor M.; Martínez Costas, José Manuel; Brissos, Rosa F.; Gamez, Patrick; Mascareñas Cid, José Luis; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Wiley, 2013)
    • Directed self-assembly of trimeric DNA-bindingchiral miniprotein helicates 

      Gómez González, Jacobo; Peña Gil, Diego; Barka, Ghofrane; Sciortino, Giuseppe; Maréchal, Jean-Didier; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Frontiers Media, 2018)
      We propose that peptides are highly versatile platforms for the precise design of supramolecular metal architectures, and particularly, for the controlled assembly of helicates. In this context, we show that the bacteriophage ...
    • High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides 

      Gamba, Ilaria; Salvadó, Iria; Brissos, Rosa F.; Gamez, Patrick; Brea Floriani, José Manuel; Loza García, María Isabel; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2016)
      We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding ...
    • Membrane-disrupting iridium(III) oligocationic organometallopeptides 

      Salvadó, Iria; Gamba, Ilaria; Montenegro García, Javier; Martínez Costas, José Manuel; Brea Floriani, José Manuel; Loza García, María Isabel; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Royal Society of Chemistry, 2016-08-19)
      A series of oligoarginine peptide derivatives containing cyclometallated iridium(III) units display remarkable cytotoxicity, comparable to that of cisplatin. In vitro studies with unilamellar vesicles support a membrane-disrupting ...
    • Programmed stereoselective assembly of DNA-binding helical metallopeptides 

      Gamba, Ilaria; Rama, Gustavo; Ortega-Carrasco, Elisabeth; Maréchal, Jean-Didier; Martínez Costas, José Manuel; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2014)
      A flexible and versatile synthetic approach for the construction of water-stable DNA-binding chiral peptide helicates based on the solid phase peptide synthesis (SPPS) methodology is reported
    • Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides 

      Bouzada, David; Salvadó, Iria; Barka, Ghofrane; Rama, Gustavo; Martínez Costas, José Manuel; Lorca, Romina; Somoza, Álvaro; Melle-Franco, Manuel; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2018)
      A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding ...
    • Sequence‐Specific DNA Recognition with Designed Peptides 

      Boga, Sonia; Bouzada, David; García Peña, Diego; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Wiley, 2018)
      Inspired by natural transcription factors (TFs), researchers have explored the potential of artificial peptides for the recognition of specific DNA sequences, developing increasingly sophisticated systems that not only ...
    • Stereoselective Formation of Chiral Metallopeptides 

      Rama, Gustavo; Ardá, Ana; Maréchal, Jean-Didier; Gamba, Ilaria; Ishida, Hitoshi; Jiménez Barbero, Jesús; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Wiley, 2012-05-03)
      Playing into our hands: The achiral bipyridine amino acid fluorenylmethyloxycarbonyl 5‐amino‐3‐oxapentanoic acid (Fmoc‐O1PenBpy‐OH) has been used for the solid‐phase synthesis of metallopeptides. Circular dichroism, molecular ...
    • The folding of a metallopeptide 

      Gamba, Ilaria; Rama, Gustavo; Ortega-Carrasco, Elisabeth; Berardozzi, Roberto; Sánchez-Pedregal, Víctor M.; Di Bari, Lorenzo; Maréchal, Jean-Didier; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2016)
      We have applied solid-phase synthesis methods for the construction of tris(bipyridyl) peptidic ligands that coordinate Fe(II) ions with high affinity and fold into stable mononuclear metallopeptides. The main factors ...





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