Browsing FIS-Artigos by Issue Date
Now showing items 21-40 of 105
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Resistin Regulates Pituitary Lipid Metabolism and Inflammation In Vivo and In Vitro
(Hindawi, 2013)The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function and also regulates growth hormone (GH) secretion in rat adenopituitary ... -
Female Nur77-deficient mice show increased susceptibility to diet-induced obesity
(PLOS, 2013)Adipose tissue is essential in the regulation of body weight. The key process in fat catabolism and the provision of energy substrate during times of nutrient deprivation or enhanced energy demand is the hydrolysis of ... -
Experimental Basis for the High Oral Toxicity of Dinophysistoxin 1: A Comparative Study of DSP
(MDPI, 2014)Okadaic acid (OA) and its analogues, dinophysistoxin 1 (DTX1) and dinophysistoxin 2 (DTX2), are lipophilic and heat-stable marine toxins produced by dinoflagellates, which can accumulate in filter-feeding bivalves. These ... -
EEG activity represents the correctness of perceptual decisions trial-by-trial
(Frontiers, 2014)Performance monitoring is an executive function, which we depend on for detecting and evaluating the consequences of our behavior. Although event related potentials (ERPs) have revealed the existence of differences after ... -
Detection of Anatoxin-a and Three Analogs in Anabaena spp. Cultures: New Fluorescence Polarization Assay and Toxin Profile by LC-MS/MS
(MDPI, 2014)Anatoxin-a (ATX) is a potent neurotoxin produced by several species of Anabaena spp. Cyanobacteria blooms around the world have been increasing in recent years; therefore, it is urgent to develop sensitive techniques that ... -
Crambescin C1 Exerts a Cytoprotective Effect on HepG2 Cells through Metallothionein Induction
(MDPI, 2015)The Mediterranean marine sponge Crambe crambe is the source of two families of guanidine alkaloids known as crambescins and crambescidins. Some of the biological effects of crambescidins have been previously reported while ... -
Circulating irisin levels are not regulated by nutritional status, obesity, or leptin levels in rodents
(Hindawi, 2015)Irisin is a cleaved and secreted fragment of fibronectin type III domain containing 5 (FNDC5) that is mainly released by skeletal muscle and was proposed to mediate the beneficial effects of exercise on metabolism. In the ... -
Study of Adsorption and Flocculation Properties of Natural Clays to Remove Prorocentrum lima
(MDPI, 2015)High accumulations of phytoplankton species that produce toxins are referred to as harmful algal blooms (HABs). HABs represent one of the most important sources of contamination in marine environments, as well as a serious ... -
In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features
(Nature Publishing Group, 2015)Pituitary adenomas comprise a heterogeneous subset of pathologies causing serious comorbidities, which would benefit from identification of novel, common molecular/cellular biomarkers and therapeutic targets. The ghrelin ... -
RB mutation and RAS overexpression induce resistance to NK cell-mediated cytotoxicity in glioma cells
(BMC, 2015)Several theories aim to explain the malignant transformation of cells, including the mutation of tumor suppressors and proto-oncogenes. Deletion of Rb (a tumor suppressor), overexpression of mutated Ras (a proto-oncogene), ... -
The Encoding of decision difficulty and movement time in the primate Premotor cortex
(PLOS, 2015)Estimating the difficulty of a decision is a fundamental process to elaborate complex and adaptive behaviour. In this paper, we show that the movement time of behaving monkeys performing a decision-making task is correlated ... -
Interaction of silver atomic quantum clusters with living organisms: bactericidal effect of Ag3 clusters mediated by disruption of topoisomerase–DNA complexes
(Royal Society of Chemistry, 2015)Essential processes for living cells such as transcription and replication depend on the formation of specific protein–DNA recognition complexes. Proper formation of such complexes requires suitable fitting between the ... -
Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice
(Nature Publishing Group, 2015)Brown and beige adipocytes recruitment in brown (BAT) or white adipose tissue, mainly in the inguinal fat pad (iWAT), meet the need for temperature adaptation in cold-exposure conditions and protect against obesity in face ... -
Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report
(MDPI, 2015)The aim of this study is to describe the results obtained after growth hormone (GH) treatment and neurorehabilitation in a young man that suffered a very grave traumatic brain injury (TBI) after a plane crash. Methods: ... -
Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression
(Oxford University Press, 2015)Background: Cumulative data indicate that the endocannabinoid system plays a major role in feeding behavior and energy balance. Genetic silencing of cannabinoid receptor type 1 (CB1) reduces body weight gain, independently ... -
Regulation of NR4A by nutritional status, gender, postnatal development and hormonal deficiency
(Nature Publishing Group, 2015)The NR4A is a subfamily of the orphan nuclear receptors (NR) superfamily constituted by three well characterized members: Nur77 (NR4A1), Nurr1 (NR4A2) and Nor 1 (NR4A3). They are implicated in numerous biological processes ... -
Neonatal events, such as androgenization and postnatal overfeeding, modify the response to ghrelin
(Nature Publishing Group, 2015)It is currently accepted that ambient, non-genetic factors influence perinatal development and evoke structural and functional changes that may persist throughout life. Overfeeding and androgenization after birth are two ... -
The cerebral cavernous malformation 3 gene is necessary for senescence induction
(Wiley, 2015)Mutations in cerebral cavernous malformation 3 gene are knownto result in development of vascular malformations and haverecently been proposed to also give rise to meningiomas. Wereport in this study that lack of CCM3 ... -
Effect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin
(PLOS, 2015)Context Metabolic substrates and nutritional status play a major role in growth hormone (GH) secretion. Uncovering the mechanisms involved in GH secretion following oral glucose (OG) administration in normal and obese ... -
Is HATCH score a reliable predictor of atrial fibrillation after cavotricuspid isthmus ablation for typical atrial flutter?
(IJC Heart & Vasculature, 2016-06-01)Objective: We determined the effectiveness of the HATCH score in patients with typical atrial flutter (AFl) undergoing cavotricuspid isthmus (CTI) ablation to predict long-term atrial fibrillation (AF). Methods: We conducted ...