Now showing items 1-20 of 64

    • 26,26,26,27,27,27-Hexadeuterated-1,25-Dihydroxyvitamin D3 (1,25D-d6) As Adjuvant of Chemotherapy in Breast Cancer Cell Lines 

      Seoane Ruzo, Samuel; Álvarez Bermúdez, María José; Sendón Lago, Juan José; Martínez Ordóñez, Anxo; Abdul-Hadi, Soraya; Maestro Saavedra, Miguel Anxo; Mouriño Mosquera, Antonio; Pérez Fernández, Román (MDPI, 2013)
      It has been demonstrated that 1,25-dihydroxyvitamin D3 (1,25D) and some of its analogues have antitumor activity. 1,25D labeled with deuterium (26,26,26,27,27,27-hexadeuterated 1a,25-dihydroxyvitamin D3, or 1,25D-d6) is ...
    • Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin 

      Abal Camaño, Paula; Louzao Ojeda, María Carmen; Vilariño del Río, Natalia; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (MDPI, 2019)
      Tetrodotoxin (TTX) is an extremely toxic marine compound produced by different genera of bacteria that can reach humans through ingestion mainly of pufferfish but also of other contaminated fish species, marine gastropods ...
    • Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging 

      Vilas Martínez, Jéssica María; Carneiro Freire, María del Carmen; Silva Álvarez, Sabela da; Ferreirós López, Alba; González, Patricia; Gómez, María; Ortega, Sagrario; Serrano, Manuel; García-Caballero Parada, Tomás; González Barcia, Luis Miguel; Vidal Figueroa, Anxo; Collado, Manuel (Wiley, 2018-08-20)
      Aging is characterized by a gradual functional decline of tissues with age. Adult stem and progenitor cells are responsible for tissue maintenance, repair, and regeneration, but during aging, this population of cells is ...
    • Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain 

      Couselo Carreira, Marcos; Andrade, Sara María Monteiro Sousa; González Izquierdo, Andrea; Amil Diz, María; Folgueira Cobos, Cintia; Crujeiras Martínez, Ana Belén; Casanueva Freijo, Felipe (Nature Publishing Group, 2018)
      The incidence of obesity has been increasing dramatically worldwide over the past decades, thus requiring novel and effective therapeutic approaches. OBEX is an oral nutritional supplement composed of antioxidants with ...
    • Antifungal Activity of the Human Uterine Cervical Stem Cells Conditioned Medium (hUCESC-CM) Against Candida albicans and Other Medically Relevant Species of Candida 

      Schneider, Jose; Mateo, Estíbaliz; Marcos Arias, Cristina; Eiró, Noemí; Vizoso, Francisco J.; Pérez Fernández, Román; Eraso, Elena; Quindós, Guillermo (Frontiers Media, 2018)
      Background: Candidiasis is a major cause of human morbidity and mortality. Human uterine cervical stem cells conditioned medium (hUCESC-CM) is obtained from stromal stem cells of the cervical transformation zone, which are ...
    • A bio-inspired hypoxia sensor using HIF1a-oxygen-dependent degradation domain 

      Iglesias, Pablo; Penas Tallón, Cristina; Barral Cagiao, Laura; Pazos Chantrero, Elena; Costoya Puente, José Antonio (Nature Publishing Group, 2019)
      Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. ...
    • Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report 

      Devesa Múgica, Jesús; Díaz Getino, Gustavo; Rey, Pablo; García Cancela, José; Loures, Iria; Nogueiras, Sonia; Hurtado de Mendoza, Alba; Salgado, Lucía; González, Mónica; Pablos, Tamara; Devesa Peleteiro, Pablo (MDPI, 2015)
      The aim of this study is to describe the results obtained after growth hormone (GH) treatment and neurorehabilitation in a young man that suffered a very grave traumatic brain injury (TBI) after a plane crash. Methods: ...
    • Central nicotine induces browning through hypothalamic κ opioid receptor 

      Seoane Collazo, Patricia; Liñares Pose, Laura; Rial Pensado, Eva; Romero Picó, Amparo; Moreno Navarrete, José María; Martínez Sánchez, Noelia; Garrido Gil, Pablo; Iglesias Rey, Ramón; Morgan, Donald A.; Tomasini, Naoki; Malone, Samuel Andrew; Senra, Ana; Folgueira Cobos, Cintia; Medina Gómez, Gema; Sobrino Moreiras, Tomás; Labandeira García, José Luis; Nogueiras Pozo, Rubén; Domingos, Ana I.; Fernández Real, José Manuel; Rahmouni, Kamal; Diéguez González, Carlos; López Pérez, Miguel Antonio (Nature Publishing Group, 2019)
      [ENG]Increased body weight is a major factor that interferes with smoking cessation. Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects both ...
    • Central nicotine induces browning through hypothalamic κ opioid receptor 

      Seoane Collazo, Patricia; Liñares Pose, Laura; Rial Pensado, Eva; Romero Picó, Amparo; Moreno Navarrete, José María; Martínez Sánchez, Noelia; Garrido Gil, Pablo; Iglesias Rey, Ramón; Morgan, Donald A.; Tomasini, Naoki; Malone, Samuel Andrew; Senra, Ana; Folgueira Cobos, Cintia; Medina Gómez, Gema; Sobrino Moreiras, Tomás; Labandeira García, José Luis; Nogueiras Pozo, Rubén; Domingos, Ana I.; Fernández Real, José Manuel; Rahmouni, Kamal; Diéguez González, Carlos; López Pérez, Miguel Antonio (Nature Publishing Group, 2019)
      [ENG]Increased body weight is a major factor that interferes with smoking cessation. Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects both feeding ...
    • Chronic In Vivo Effects of Repeated Exposure to Low Oral Doses of Tetrodotoxin: Preliminary Evidence of Nephrotoxicity and Cardiotoxicity 

      Boente Juncal, Andrea; Vale González, María del Carmen; Cifuentes Martínez, José Manuel; Otero Fuertes, María Paz; Camiña García, María Mercedes; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (MDPI, 2019)
      Tetrodotoxin (TTX) is one of the most potent naturally occurring neurotoxins. Initially TTX was associated with human food intoxications in Japan, but nowadays, concerns about the human health risks posed by TTX have ...
    • Circulating irisin levels are not regulated by nutritional status, obesity, or leptin levels in rodents 

      Quiñones Téllez, María del Mar; Folgueira Cobos, Cintia; Sánchez Rebordelo, María Estrella; Al-Massadi Iglesias, Omar (Hindawi, 2015)
      Irisin is a cleaved and secreted fragment of fibronectin type III domain containing 5 (FNDC5) that is mainly released by skeletal muscle and was proposed to mediate the beneficial effects of exercise on metabolism. In the ...
    • Context-dependent impact of RAS oncogene expression on cellular reprogramming to pluripotency 

      Ferreirós López, Alba; Pedrosa, Pablo; Silva Álvarez, Sabela da; Triana Martínez, Francisco; Vilas Martínez, Jéssica María; Picallos Rabina, Pilar; González, Patricia; Gómez, María; Li, Han; García-Caballero Parada, Tomás; González Barcia, Miguel; Vidal Figueroa, Anxo; Collado, Manuel (Cell Press, 2019)
      Induction of pluripotency in somatic cells with defined genetic factors has been successfully used to investigate the mechanisms of disease initiation and progression. Cellular reprogramming and oncogenic transformation ...
    • CPT1C in the ventromedial nucleus of thehypothalamus is necessary for brown fatthermogenesis activation in obesity 

      Rodríguez Rodríguez, Rosalía; Miralpeix, Cristina; Fosch, Anna; Pozo, Macarena; Calderón Domínguez, María; Perpinyà, Xavier; Vellvehí, Miquel; López Pérez, Miguel Antonio; Herrero, Laura; Serra, Dolors; Casals, Núria (Elsevier, 2019)
      Objective:Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigatewhether CPT1C in the ventromedial nucleus of the hypothalamus (VMH) is involved in ...
    • Decision-making in the ventral premotor cortex harbinger of action 

      Pardo Vázquez, José Luis; Padrón Rodríguez, Isabel; Fernández Rey, José; Acuña Castroviejo, Carlos (Frontiers, 2011)
      Although the premotor (PM) cortex was once viewed as the substrate of pure motor func- tions, soon it was realized that it was involved in higher brain functions. By this it is meant that the PM cortex functions would ...
    • Detoxifying antitumoral drugs via nanoconjugation: the case of gold nanoparticles and cisplatin 

      Comenge, Joan; Sotelo Goyanes, María Carmen; Romero, Francisco; Gallego, Óscar; Barnadas, Agustí; García-Caballero Parada, Tomás; Domínguez Puente, Fernando Ignacio; Puntes, Víctor F. (PLOS, 2012)
      Nanoparticles (NPs) have emerged as a potential tool to improve cancer treatment. Among the proposed uses in imaging and therapy, their use as a drug delivery scaffold has been extensively highlighted. However, there are ...
    • Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice 

      Pazos Mendoza, Patricia; Lima Rodríguez, Luis; Tovar Carro, Sulay A.; González Touceda, David; Diéguez González, Carlos; García García, María del Carmen (Nature Publishing Group, 2015)
      Brown and beige adipocytes recruitment in brown (BAT) or white adipose tissue, mainly in the inguinal fat pad (iWAT), meet the need for temperature adaptation in cold-exposure conditions and protect against obesity in face ...
    • EEG activity represents the correctness of perceptual decisions trial-by-trial 

      Pardo Vázquez, José Luis; Padrón Rodríguez, Isabel; Fernández Rey, José; Acuña Castroviejo, Carlos (Frontiers, 2014)
      Performance monitoring is an executive function, which we depend on for detecting and evaluating the consequences of our behavior. Although event related potentials (ERPs) have revealed the existence of differences after ...
    • Effect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin 

      Pena Bello, Lara; Pértega Díaz, Sonia; Outeiriño Blanco, Elena; García Buela, Jesús; Tovar Carro, Sulay A.; Sangiao Alvarellos, Susana; Diéguez González, Carlos; Cordido Carballido, Fernando (PLOS, 2015)
      Context Metabolic substrates and nutritional status play a major role in growth hormone (GH) secretion. Uncovering the mechanisms involved in GH secretion following oral glucose (OG) administration in normal and obese ...
    • Effects of recombinant growth hormone (GH) replacement and psychomotor and cognitive stimulation in the neurodevelopment of GH-deficient (GHD) children with cerebral palsy: a pilot study 

      Devesa Múgica, Jesús; Alonso, Begoña; Casteleiro, Nerea; Couto, Paula; Castañón, Beatriz; Zas, Eva; Reimunde Figueira, Pedro Marcos (Dove Medical Press, 2011)
      Cerebral palsy (CP) is the main cause of physical disability in childhood and is an important health issue that has a strong socioeconomic impact. There is no effective treatment for CP and therapeutic approaches report ...
    • Effects of recombinant growth hormone replacement and physical rehabilitation in recovery of gross motor function in children with cerebral palsy 

      Reimunde Figueira, Pedro Marcos; Rodicio, Cristina; López, Natalia; Alonso, Alba; Devesa Peleteiro, Pablo; Devesa Múgica, Jesús (Dove Press, 2010)
      Cerebral palsy is an important health issue that has a strong socioeconomic impact. There is no cure for cerebral palsy, and therapeutic approaches only report small benefits for affected people. In this study we assessed ...





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