Mostrar o rexistro simple do ítem

dc.contributor.authorAlonso López, Eva
dc.contributor.authorAlvariño Romero, Rebeca
dc.contributor.authorLeirós Villalba, Marta
dc.contributor.authorTabudravu, Jioji N.
dc.contributor.authorFeussner, Klaus
dc.contributor.authorDam, Miriam A.
dc.contributor.authorRateb, Mostafa E.
dc.contributor.authorJaspars, Marcel
dc.contributor.authorBotana López, Luis Miguel
dc.date.accessioned2017-10-19T11:33:09Z
dc.date.available2017-10-19T11:33:09Z
dc.date.issued2016-10
dc.identifier.citationAlonso, E., Alvariño, R., Leirós, M., Tabudravu, J. N., Feussner, K., Dam, M. A., ... & Botana, L. M. (2016). Evaluation of the antioxidant activity of the marine pyrroloiminoquinone makaluvamines. Marine drugs, 14(11), 197.
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10347/15866
dc.description.abstractMakaluvamines are pyrroloiminoquinones isolated from Zyzzya sponges. Until now, they have been described as topoisomerase II inhibitors with cytotoxic effects in diverse tumor cell lines. In the present work, seven makaluvamines were tested in several antioxidant assays in primary cortical neurons and neuroblastoma cells. Among the alkaloids studied, makaluvamine J was the most active in all the assays. This compound was able to reduce the mitochondrial damage elicited by the well-known stressor H2O2. The antioxidant properties of makaluvamine J are related to an improvement of the endogenous antioxidant defenses of glutathione and catalase. SHSY5Y assays proved that this compound acts as a Nrf2 activator leading to an improvement of antioxidant defenses. A low concentration of 10 nM is able to reduce the reactive oxygen species release and maintain a correctmitochondrial function. Based on these results, non-substituted nitrogen in the pyrrole plus the presence of a p-hydroxystyryl without a double bond seems to be the most active structure with a complete antioxidant effect in neuronal cells.
dc.description.sponsorshipThe research leading to these results received funding from the following FEDER cofounded-grants. From CDTI and Technological Funds, supported by the Ministerio de Economía y Competitividad, AGL2012-40185-CO2-01, AGL2014-58210-R, and the Consellería de Cultura, Educación e Ordenación Universitaria, GRC2013-016, and through the Axencia Galega de Innovación, Spain, ITC-20133020 SINTOX. From CDTI under ISIP Programme, Spain, IDI-20130304 APTAFOOD. From the European Union’s Seventh Framework Programme managed by REA—Research Executive Agency (FP7/2007-2013) under grant agreement 312184 PHARMASEA.
dc.language.isoeng
dc.publisherMDPI
dc.rightsCopyright by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMakaluvamine
dc.subjectZyzzya
dc.subjectOxidative stress
dc.subjectNeurons
dc.subjectMarine sponge
dc.subjectnrf2
dc.subject.classificationMaterias::Investigación::32 Ciencias médicas::3209 Farmacología
dc.titleEvaluation of the antioxidant activity of the marine pyrroloiminoquinone makaluvamines
dc.typejournal article
dc.identifier.doi10.3390/md14110197
dc.relation.publisherversionhttp://doi.org/10.3390/md14110197
dc.type.hasVersionVoR
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.description.peerreviewedSI
dc.relation.projectIDinfo:eu-repo//grantAgreement/FP7/312184
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-58210-R/ES/EVALUACION DE LA SEGURIDAD ALIMENTARIA DE PRODUCTOS PESQUEROS ASOCIADA A LA PRESENCIA DE TOXINAS MARINAS DE NUEVA APARICION EN AGUAS EUROPEAS


Ficheiros no ítem

application/pdf
Nome: 2016_Mar Drugs_Alonso_Evaluation.pdf
Tamaño: 2.142 Mb
Formato: PDF


Thumbnail

Este ítem aparece na(s) seguinte(s) colección(s)

Mostrar o rexistro simple do ítem

Copyright by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
A licenza do ítem descríbese como
 Copyright by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).





Recolectores:Enlaces de interese:
Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contacto | Suxestións