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dc.contributor.author | Alonso López, Eva |
dc.contributor.author | Alvariño Romero, Rebeca |
dc.contributor.author | Leirós Villalba, Marta |
dc.contributor.author | Tabudravu, Jioji N. |
dc.contributor.author | Feussner, Klaus |
dc.contributor.author | Dam, Miriam A. |
dc.contributor.author | Rateb, Mostafa E. |
dc.contributor.author | Jaspars, Marcel |
dc.contributor.author | Botana López, Luis Miguel |
dc.date.accessioned | 2017-10-19T11:33:09Z |
dc.date.available | 2017-10-19T11:33:09Z |
dc.date.issued | 2016-10 |
dc.identifier.citation | Alonso, E., Alvariño, R., Leirós, M., Tabudravu, J. N., Feussner, K., Dam, M. A., ... & Botana, L. M. (2016). Evaluation of the antioxidant activity of the marine pyrroloiminoquinone makaluvamines. Marine drugs, 14(11), 197. |
dc.identifier.issn | 1660-3397 |
dc.identifier.uri | http://hdl.handle.net/10347/15866 |
dc.description.abstract | Makaluvamines are pyrroloiminoquinones isolated from Zyzzya sponges. Until now, they have been described as topoisomerase II inhibitors with cytotoxic effects in diverse tumor cell lines. In the present work, seven makaluvamines were tested in several antioxidant assays in primary cortical neurons and neuroblastoma cells. Among the alkaloids studied, makaluvamine J was the most active in all the assays. This compound was able to reduce the mitochondrial damage elicited by the well-known stressor H2O2. The antioxidant properties of makaluvamine J are related to an improvement of the endogenous antioxidant defenses of glutathione and catalase. SHSY5Y assays proved that this compound acts as a Nrf2 activator leading to an improvement of antioxidant defenses. A low concentration of 10 nM is able to reduce the reactive oxygen species release and maintain a correctmitochondrial function. Based on these results, non-substituted nitrogen in the pyrrole plus the presence of a p-hydroxystyryl without a double bond seems to be the most active structure with a complete antioxidant effect in neuronal cells. |
dc.description.sponsorship | The research leading to these results received funding from the following FEDER cofounded-grants. From CDTI and Technological Funds, supported by the Ministerio de Economía y Competitividad, AGL2012-40185-CO2-01, AGL2014-58210-R, and the Consellería de Cultura, Educación e Ordenación Universitaria, GRC2013-016, and through the Axencia Galega de Innovación, Spain, ITC-20133020 SINTOX. From CDTI under ISIP Programme, Spain, IDI-20130304 APTAFOOD. From the European Union’s Seventh Framework Programme managed by REA—Research Executive Agency (FP7/2007-2013) under grant agreement 312184 PHARMASEA. |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.rights | Copyright by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.subject | Makaluvamine |
dc.subject | Zyzzya |
dc.subject | Oxidative stress |
dc.subject | Neurons |
dc.subject | Marine sponge |
dc.subject | nrf2 |
dc.subject.classification | Materias::Investigación::32 Ciencias médicas::3209 Farmacología |
dc.title | Evaluation of the antioxidant activity of the marine pyrroloiminoquinone makaluvamines |
dc.type | journal article |
dc.identifier.doi | 10.3390/md14110197 |
dc.relation.publisherversion | http://doi.org/10.3390/md14110197 |
dc.type.hasVersion | VoR |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica |
dc.description.peerreviewed | SI |
dc.relation.projectID | info:eu-repo//grantAgreement/FP7/312184 |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-58210-R/ES/EVALUACION DE LA SEGURIDAD ALIMENTARIA DE PRODUCTOS PESQUEROS ASOCIADA A LA PRESENCIA DE TOXINAS MARINAS DE NUEVA APARICION EN AGUAS EUROPEAS |
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