Ultrasound- and Molecular Sieves-Assisted Synthesis, Molecular Docking and Antifungal Evaluation of 5-(4-(Benzyloxy)-substituted phenyl)-3- ((phenylamino)methyl)-1,3,4-oxadiazole-2(3H)-thiones
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Title: | Ultrasound- and Molecular Sieves-Assisted Synthesis, Molecular Docking and Antifungal Evaluation of 5-(4-(Benzyloxy)-substituted phenyl)-3- ((phenylamino)methyl)-1,3,4-oxadiazole-2(3H)-thiones |
Author: | Nimbalkar, Urja D. Tupe, Santosh G. Seijas Vázquez, Julio Antonio Kalam Khan, Firoz A. Nikalje, Anna Pratima G. |
Affiliation: | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Subject: | 1,3,4-oxadiazoles | Ultrasound | Mannich reaction | Molecular sieves | Antifungal activity | Molecular docking | |
Date of Issue: | 2016-05-10 |
Publisher: | MPDI |
Citation: | Nimbalkar, U.D.; Tupe, S.G.; Seijas Vazquez, J.A.; Khan, F.A.K.; Sangshetti, J.N.; Nikalje, A.P.G. Ultrasound- and Molecular Sieves-Assisted Synthesis, Molecular Docking and Antifungal Evaluation of 5-(4-(Benzyloxy)-substituted phenyl)-3-((phenylamino)methyl)-1,3,4-oxadiazole-2(3H)-thiones. Molecules 2016, 21, 484 |
Abstract: | A novel series of 5-(4-(benzyloxy)substituted phenyl)-3-((phenyl amino)methyl)-1,3,4-oxadiazole-2(3H)-thione Mannich bases 6a–o were synthesized in good yield from the key compound 5 (4(benzyloxy)phenyl)-1,3,4-oxadiazole-2(3H)-thione by aminomethylation with paraformaldehyde and substituted amines using molecular sieves and sonication as green chemistry tools. The antifungal activity of the new products was evaluated against seven human pathogenic fungal strains, namely, Candida albicans ATCC 24433, Candida albicans ATCC 10231, Candida glabrata NCYC 388, Cryptococcus neoformans ATCC 34664, Cryptococcus neoformans PRL 518, Aspergillus fumigatus NCIM 902 and Aspergillus niger ATCC 10578. The synthesized compounds 6d, 6f, 6g, 6h and 6j exhibited promising antifungal activity against the tested fungal pathogens. In molecular docking studies, derivatives 6c, 6f and 6i showed good binding at the active site of C. albicans cytochrome P450 enzyme lanosterol 14 α-demethylase. The in vitro antifungal activity results and docking studies indicated that the synthesized compounds have potential antifungal activity and can be further optimized as privileged scaffolds to design and develop potent antifungal drugs |
Publisher version: | https://doi.org/10.3390/molecules21050484 |
URI: | http://hdl.handle.net/10347/15895 |
DOI: | 10.3390/molecules21050484 |
ISSN: | 1420-3049 |
Rights: | © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/) |
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Except where otherwise noted, this item's license is described as © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/)