Yessotoxin, a promising therapeutic tool
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| Title: | Yessotoxin, a promising therapeutic tool |
| Author: | Alfonso Rancaño, María Amparo Rodríguez Vieytes, María Mercedes Botana López, Luis Miguel |
| Affiliation: | Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica Universidade de Santiago de Compostela. Departamento de Fisioloxía |
| Subject: | Yessotoxin (YTX) | Apoptosis | Autophagy | Cellular death | Signal transduction | Cytoskeleton | Immune system | Alzheimer | Glucose metabolism | |
| Date of Issue: | 2016-01-28 |
| Publisher: | MDPI |
| Citation: | Alfonso, A.; Vieytes, M.R.; Botana, L.M. Yessotoxin, a Promising Therapeutic Tool. Mar. Drugs 2016, 14, 30 |
| Abstract: | Yessotoxin (YTX) is a polyether compound produced by dinoflagellates and accumulated in filter feeding shellfish. No records about human intoxications induced by this compound have been published, however it is considered a toxin. Modifications in second messenger levels, protein levels, immune cells, cytoskeleton or activation of different cellular death types have been published as consequence of YTX exposure. This review summarizes the main intracellular pathways modulated by YTX and their pharmacological and therapeutic implications |
| Publisher version: | https://doi.org/10.3390/md14020030 |
| URI: | http://hdl.handle.net/10347/15901 |
| DOI: | 10.3390/md14020030 |
| E-ISSN: | 1660-3397 |
| Rights: | © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/) |
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Except where otherwise noted, this item's license is described as © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/)