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dc.contributor.author | Alfonso Rancaño, María Amparo |
dc.contributor.author | Rodríguez Vieytes, María Mercedes |
dc.contributor.author | Botana López, Luis Miguel |
dc.date.accessioned | 2017-10-20T16:34:09Z |
dc.date.available | 2017-10-20T16:34:09Z |
dc.date.issued | 2016-01-28 |
dc.identifier.citation | Alfonso, A.; Vieytes, M.R.; Botana, L.M. Yessotoxin, a Promising Therapeutic Tool. Mar. Drugs 2016, 14, 30 |
dc.identifier.uri | http://hdl.handle.net/10347/15901 |
dc.description.abstract | Yessotoxin (YTX) is a polyether compound produced by dinoflagellates and accumulated in filter feeding shellfish. No records about human intoxications induced by this compound have been published, however it is considered a toxin. Modifications in second messenger levels, protein levels, immune cells, cytoskeleton or activation of different cellular death types have been published as consequence of YTX exposure. This review summarizes the main intracellular pathways modulated by YTX and their pharmacological and therapeutic implications |
dc.description.sponsorship | The research leading to these results has received funding from the following FEDER cofunded grants. From CDTI and Technological Funds, supported by Ministerio de Economía y Competitividad, AGL2012-40185-CO2-01, AGL2014-58210-R; Consellería de Cultura, Educación e Ordenación Universitaria, GRC2013-016; CDTI under ISIP Programme, Spain, IDI-20130304 APTAFOOD; and the European Union’s Seventh Framework Programme managed by REA—Research Executive Agency (FP7/2007–2013) under grant agreement 312184 PHARMASEA |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.rights | © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/) |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.subject | Yessotoxin (YTX) |
dc.subject | Apoptosis |
dc.subject | Autophagy |
dc.subject | Cellular death |
dc.subject | Signal transduction |
dc.subject | Cytoskeleton |
dc.subject | Immune system |
dc.subject | Alzheimer |
dc.subject | Glucose metabolism |
dc.title | Yessotoxin, a promising therapeutic tool |
dc.type | journal article |
dc.identifier.doi | 10.3390/md14020030 |
dc.relation.publisherversion | https://doi.org/10.3390/md14020030 |
dc.type.hasVersion | VoR |
dc.identifier.essn | 1660-3397 |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Fisioloxía |
dc.description.peerreviewed | SI |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/312184 |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-58210-R/ES/EVALUACION DE LA SEGURIDAD ALIMENTARIA DE PRODUCTOS PESQUEROS ASOCIADA A LA PRESENCIA DE TOXINAS MARINAS DE NUEVA APARICION EN AGUAS EUROPEAS |
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