Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice
Por favor, use este identificador para citas ou ligazóns a este ítem:
http://hdl.handle.net/10347/15929
Ficheiros no ítem
Metadatos do ítem
Título: | Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice |
Autor/a: | Luque, Raúl M. Cordoba-Chacon, Jose Pozo-Salas, Ana I. Porteiro, Begoña de Lecea, Luis Nogueiras Pozo, Rubén Gahete, Manuel D Castaño, Justo P. |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas |
Palabras chave: | Obesity | Pituitary gland | |
Data: | 2016-11-30 |
Editor: | Springer Nature |
Cita bibliográfica: | Luque, R. M. et al. Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice. Sci. Rep. 6, 37992; doi: 10.1038/srep37992 (2016) |
Resumo: | Somatostatin (SST) and cortistatin (CORT) regulate numerous endocrine secretions and their absence [knockout (KO)-models] causes important endocrine-metabolic alterations, including pituitary dysregulations. We have demonstrated that the metabolic phenotype of single or combined SST/CORT KO-models is not drastically altered under normal conditions. However, the biological actions of SST/CORT are conditioned by the metabolic-status (e.g. obesity). Therefore, we used male/female SST- and CORT-KO mice fed low-fat (LF) or high-fat (HF) diet to explore the interplay between SST/CORT and obesity in the control of relevant pituitary-axes and whole-body metabolism. Our results showed that the SST/CORT role in the control of GH/prolactin secretions is maintained under LF- and HF-diet conditions as SST-KOs presented higher GH/prolactin-levels, while CORT-KOs displayed higher GH- and lower prolactin-levels than controls under both diets. Moreover, the impact of lack of SST/CORT on the metabolic-function was gender- and diet-dependent. Particularly, SST-KOs were more sensitive to HF-diet, exhibiting altered growth and body-composition (fat/lean percentage) and impaired glucose/insulin-metabolism, especially in males. Conversely, only males CORT-KO under LF-diet conditions exhibited significant alterations, displaying higher glucose-levels and insulin-resistance. Altogether, these data demonstrate a tight interplay between SST/CORT-axis and the metabolic status in the control of endocrine/metabolic functions and unveil a clear dissociation of SST/CORT roles |
Versión do editor: | http://dx.doi.org/10.1038/srep37992 |
URI: | http://hdl.handle.net/10347/15929 |
DOI: | 10.1038/srep37992 |
ISSN: | 2045-2322 |
Dereitos: | © The Author(s) 2016 Atribución 3.0 España |
Coleccións
-
- CIMUS-Artigos [249]
O ítem ten asociados os seguintes ficheiros de licenza: