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dc.contributor.authorAbal Camaño, Paula
dc.contributor.authorLouzao Ojeda, María Carmen
dc.contributor.authorAntelo Queijo, Álvaro
dc.contributor.authorAlvarez, Mercedes
dc.contributor.authorCagide, Eva
dc.contributor.authorVilariño del Río, Natalia
dc.contributor.authorRodríguez Vieytes, María Mercedes
dc.contributor.authorBotana López, Luis Miguel
dc.identifier.citationAbal, P., Louzao, M. C., Antelo, A., Alvarez, M., Cagide, E., Vilariño, N., ... & Botana, L. M. (2017). Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL). Toxins, 9(3), 75.
dc.description.abstractTetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to a safe seafood level for TTX, oral toxicity data are required. In this study, a 4-level Up and Down Procedure was designed in order to determine for the first time the oral lethal dose 50 (LD50) and the No Observed Adverse Effect Level (NOAEL) in mice by using an accurate well-characterized TTX standar
dc.description.sponsorshipThe research leading to these results has received funding from the following FEDER cofounded-grants. From CDTI and Technological Funds, supported by Ministerio de Economia, Industria y Competitividad, AGL2014-58210-R, AGL2016-78728-R, ISCIII/PI16/01830 and RTC-2016-5507-2. From CDTI under ISIP Programme, Spain, IDI-20130304 APTAFOOD and ITC-20161072. From the European Union’s Seventh Framework Programme managed by REA – Research Executive Agency (FP7/2007-2013) under grant agreement 312184 PHARMASEA
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rights© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
dc.subjectAcute oral toxicity
dc.subjectEuropean molluscs
dc.subjectLethal dose
dc.subjectNo observed adverse effect level (NOAEL)
dc.subjectRisk assessment
dc.titleAcute oral toxicity of tetrodotoxin in mice: determination of lethal dose 50 (LD50) and no observed adverse effect level (NOAEL)
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Fisioloxía

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