Yessotoxin, a Marine Toxin, Exhibits AntiAllergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model
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Title: | Yessotoxin, a Marine Toxin, Exhibits AntiAllergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model |
Author: | Tobío Ageitos, Araceli Alfonso Rancaño, María Amparo Madera-Salcedo, Iris K. Botana López, Luis Miguel Blank, Ulrich |
Affiliation: | Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica |
Date of Issue: | 2016-12-14 |
Publisher: | PLOS |
Citation: | Tobío A, Alfonso A, Madera-Salcedo I, Botana LM, Blank U (2016) Yessotoxin, a Marine Toxin, Exhibits Anti-Allergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model. PLoS ONE 11(12): e0167572. https://doi.org/10.1371/journal.pone.0167572 |
Abstract: | Yessotoxins (YTXs) are a group of marine toxins produced by the dinoflagellates Protoceratium reticulatum, Lingulodinium polyedrum and Gonyaulax spinifera. They may have medical interest due to their potential role as anti-allergic but also anti-cancer compounds. However, their biological activities remain poorly characterized. Here, we show that the small molecular compound YTX causes a slight but significant reduction of the ability of mast cells to degranulate. Strikingly, further examination revealed that YTX had a marked and selective cytotoxicity for the RBL-2H3 mast cell line inducing apoptosis, while primary bone marrow derived mast cells were highly resistant. In addition, YTX exhibited strong cytotoxicity against the human B-chronic lymphocytic leukaemia cell line MEC1 and the murine melanoma cell line B16F10. To analyse the potential role of YTX as an anti-cancer drug in vivo we used the well-established B16F10 melanoma preclinical mouse model. Our results demonstrate that a few local application of YTX around established tumours dramatically diminished tumour growth in the absence of any significant toxicity as determined by the absence of weight loss and haematological alterations. Our data support that YTX may have a minor role as an anti-allergic drug, but reveals an important potential for its use as an anti-cancer drug |
Publisher version: | https://doi.org/10.1371/journal.pone.0167572 |
URI: | http://hdl.handle.net/10347/15947 |
DOI: | 10.1371/journal.pone.0167572 |
ISSN: | 1932-6203 |
Rights: | © 2016 Tobío et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Atribución 3.0 España |
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